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science.sciencemag.org/content/early/2020/07/10/science.abc6027

=============================================================================

Abstract

Coronavirus disease 2019 (COVID-19) is characterized by distinct patterns of disease progression suggesting diverse host immune responses. We performed an integrated immune analysis on a cohort of 50 COVID-19 patients with various disease severity. A unique phenotype was observed in severe and critical patients, consisting of a highly impaired interferon (IFN) type I response (characterized by no IFN-£] and low IFN-£\ production and activity), associated with a persistent blood viral load and an exacerbated inflammatory response. Inflammation was partially driven by the transcriptional factor NF-£eB and characterized by increased tumor necrosis factor (TNF)-£\ and interleukin (IL)-6 production and signaling. These data suggest that type-I IFN deficiency in the blood could be a hallmark of severe COVID-19 and provide a rationale for combined therapeutic approaches.

===================================================================================================

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#1

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patientpower.info/myeloproliferative-neoplasms/treatments/new-treatments-provide-hope-for-patients-with-mpns

New Treatments Provide Hope for Patients with MPNs

Dr. Naveen Pemmaraju, an associate professor in the Department of Leukemia at MD Anderson Cancer Center in Houston, Texas, who was also part of the panel, said ropeginterferon alfa-2b is also showing promise in patients with PV. The interferon was recently approved in Europe; the FDA is expected to approve the drug for use in the U.S. next year.

He said ropeginterferon alfa-2b is an improvement over peginterferon alfa-2a (Pegasys) because it is an injection once every two weeks, rather than once a week, and it has fewer side effects.

¡§¡Kthe results (from the trials) really look very encouraging now at four years plus follow up that people can stay on this drug for a long period of time,¡¨ he said. ¡§Less side effects than we expected. And possibly a signal for less MPN events such as thrombosis, like blood clots. Of course, longer follow up is needed.¡¨

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#2

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www.targetedonc.com/view/ropeginterferon-provides-improved-hematocrit-control-over-phlebotomy-alone-in-low-risk-pv

Ropeginterferon Provides Improved Hematocrit Control Over Phlebotomy Alone in Low-Risk PV

June 15, 2020

This interim analysis demonstrated ropeginterferon in low-risk patients is more efficacious in keeping the hematocrit [at target levels]. In addition, we get a better quality of life and the target was reached with a reduction of phlebotomy needs.

...........

EHA commentator Ruud Delwel, PhD, noted that the interim results of the study already challenge standard practice and this important study will continue to be discussed for years with further follow-up results. Barbui said that these findings require further follow-up and the secondary end points will be assessed following the conclusion of the second year of the trial.

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

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·|­û¡G¤p´²¤á10028616  µoªí®É¶¡:2020/7/16 ¤W¤È 09:52:04²Ä 9188 ½g¦^À³
www.pharmac.govt.nz/medicines/my-medicine-has-changed/interferon-alfa-2a-roferon-a-discontinuation/

Interferon alfa-2a (Roferon-A): Discontinuation

Interferon alfa-2a can be used to treat T cell lymphomas and myeloproliferative disorders.

Interferon alfa-2a (Roferon-A) being discontinued

At the end of June 2020, Roche, the supplier of interferon alfa-2a (Roferon-A) will stop making this medicine globally. We understand that this change will affect about 25 people who currently take interferon alfa-2a.

PHARMAC¡¦s expert advice has confirmed that interferon alfa-2a is mainly used to treat:

• myeloproliferative disorders where patients can¡¦t take other funded alternatives (including patients who are pregnant or actively planning to become pregnant)

• T cell lymphomas, such as mycosis fungoides.

PHARMAC understands that interferon alfa-2a is no longer used to treat hepatitis C.

.

.

What we¡¦re doing

PHARMAC has widened access to pegylated interferon alfa-2a so that patients currently taking interferon alfa-2a can access an appropriate alternative. This will take effect from 1 July 2020.

Information for pharmacists

At the end of June 2020, Roche will discontinue interferon alfa-2a (Roferon-A, Pharmacode 483206).

PHARMAC has widened the access criteria for pegylated interferon alfa-2a (Pegasys, Pharmacode 2162806) to patients with myeloproliferative disorder and cutaneous T cell lymphoma. This will take effect from 1 July 2020.

We¡¦re asking prescribers to transition their patients to an alternative treatment.

Interferon alfa-2a (Roferon-A) will be delisted from 1 December 2020 to allow time for residual supplies of this product to be dispensed and claimed for.

Key dates for prescribers and pharmacists

• 30 June 2020 ¡V Roche stops supplying interferon alfa-2a (Roferon-A)

• 1 July 2020 ¡V Pegylated interferon alfa-2a Special Authority criteria widened to include myeloproliferative disorder and cutaneous T cell lymphoma

• 1 December 2020 ¡V interferon alfa-2a (Roferon-A) delisted from the Pharamceutcial Schedule

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·|­û¡G¤p¥¿¥¿10142326  µoªí®É¶¡:2020/7/15 ¤U¤È 06:06:34²Ä 9187 ½g¦^À³
www.globenewswire.com/news-release/2020/07/15/2062388/0/en/Polycythemia-Vera-Market-Report-2017-2030-Trends-in-the-United-States-Germany-Spain-Italy-France-United-Kingdom-and-Japan.html

Dublin, July 15, 2020

Polycythemia Vera Market Report 2017-2030: Trends in the United States, Germany, Spain, Italy, France, United Kingdom and Japan

¤@¡BMarketed Drugs

Jakafi, Jakavi (Ruxolitinib): Incyte Corporation/Novartis

Besremi: AOP Orphan Pharmaceuticals AG/ PharmaEssentia

¤G¡BEmerging Drugs

Givinostat: Italfarmaco

PTG-300: Protagonist Therapeutics

PRM-151: Promedior/Roche

¤T¡BMarket Outlook

The market size of PV has been assessed to undergo tough competition, wherein Jakafi is likely to maintain dominance in the hydroxyurea-refractory (second line) PV market. On the other hand, Besremi represents an even small risk, as the drug is being positioned in first-line treatment for PV vs. hydroxyurea.

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¼W¸ê§¹, µu½u®M§QªÌ»°§Ö½æ¤@½æ, ¤¤ªø½u¤Ï¦Ó¬O¦n¨Æ .....!

­Ó¤H¡¦¡¦°¾¨£¡¦¡¦: ¬ð¯}ÀV½u»P¾ú¥v°ªÂI¥u¬O¿ð¦­ªº¨Æ.....

~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~~

EHA¦~·|ªº¸q¤j§Q¦å²G¾Ç±Ð±ÂTiziano Barbui³Õ¤h¿Ë¦Û©ó²Ä25©¡¼Ú¬w¦å²G¾Ç¦~·|(European Hematology Association, EHA 25)ªº¤å³¹­«ÂIÁöµM¦b6/15´N¦bÃĵةxºô¥Z¥X¤¤¤å½Ķ­«ÂI (µù1);

¸Ó¤å©ó7/13 ¤]¥Zµn¦bMPN Hub¸ê°T¥­¥x­º­¶ (µù2) - ¬Q¤é7/14¤S¬Ý¨ì¼Ú¬wKOL Dr. JJ Kilidjian (¤Ú¾¤¸t¸ô©ö¤h¤j¾Ç±Ð±Â/¸t¸ô©ö¤hÂå°|¦å²GÁ{§É±Ð±ÂÂå¥Í) ¦b¥LªºTwitter Âà±À³o½gMPN Hub ¤å³¹! ¬Û«H¹ïMPN (¥þ²y) ¯f¤H©Î¬O¬ÛÃö»â°ìÂå¥Í±M®a¾ÇªÌ ³£¬O«Ü¤£¿ùªº±Ð¨|»P«Å¶Ç! Very Good!

³z¹L¼Ú¬wÂå¥Í/¾ÇªÌ¦pDr. JJ Kilidjian ªºTwitterªÀ¸s´CÅé ©ÎÃþ¦ü¹³MPN Hub

(µù3), (European LeukemiaNet (ELN)) ¸ê°T¥­¥xªº±Ð¨|»P¶Ç»¼, ¬Û«H¹ïÃĵØRopeginterferon ¬O³Ìª½±µªºªÖ©w!

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God Bless PharmaEssentia & its lovers!

µù1:

(www.pharmaessentia.com/tw/news_latestdetail/¥»¤½¥q¤§P1101ªvÀø§C­·ÀIPV¯f±w±Ú¸s¦¨ªG¨ô¶V)

µù2:

Results of the phase II trial Low-PV: Ropeginterferon versus phlebotomy for low risk PV³Q¥Zµn¦b³Ì·sªºMPN Hub©xºô­º­¶!!! mpn-hub.com/

mpn-hub.com/medical-information/results-of-the-phase-ii-trial-low-pv-ropeginterferon-versus-phlebotomy-for-low-risk-pv

Results of the phase II trial Low-PV: Ropeginterferon versus phlebotomy for low risk PV [Sylvia Agathou; Tiziano Barbui Jul 13, 2020]

µù3:

About us: (Ãö©ó§Ú­Ì)

MPN Hub¤¤¤ß¬O¤@­Ó¶}©ñ¦¡ªº½u¤W¸ê·½ªA°È, ­P¤O©ó¦b MPN»â°ì¤¤´£¨Ñ¥­¿Å¡B¥i«H©M³Ì·sªºÂå¾Ç±Ð¨|¡C¥Ø¼Ð¬O³q¹L¦hºÞ¹D¶Ç¼½»P MPN ¤ÀÃþ¡B¶EÂ_¡BªvÀø©MºÞ²z¬ÛÃöªº¥þ²y¶i®i,´£°ª MPN ªºª¾ÃÑ¡C

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Can boosting interferons, the body¡¦s frontline virus fighters, beat COVID-19?

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An Open-label, Randomized, Active Control Study to Demonstrate Non-Inferiority in Efficacy, and to Compare Safety and Tolerability of P1101 + Ribavirin to PEG-Intron + Ribavirin in Interferon Treatment-Naive Subjects with Chronic HCV Genotype 2 Infection

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Humira: ad spend in the U.S. 2014-2018 Published by A. Guttmann, Jul 1, 2020

In 2018, AbbVie¡¦s advertising spending on Humira in the United States reached 483 million U.S. dollars.

AbbVie¡¦s advertising spending on Humira in the United States from 2014 to 2018(in million U.S. dollars)

www.statista.com/statistics/318301/humira-ad-spend-usa/

2014-3.56»õ¬ü¤¸

2015-3.57»õ¬ü¤¸

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