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Again....And summarize the key points...

www.oncologynurseadvisor.com/home/cancer-types/myeloproliferative-neoplasms/effects-of-germline-genetic-factors-on-interferon-alpha-therapy-in-polycythemia-vera/

September 29, 2020

Germline Factors Affect Molecular Response to Treatment for Polycythemia Vera

Germline polymorphisms can affect response to treatment in people with polycythemia vera (PV). A diplotype in IFNL4 is significantly linked to molecular response, which suggests that interferon alpha (IFN£\) may directly affect JAK2V617F burden, according to research published in Blood.

......

¡§These results indicate that all patients with PV may be eligible for ropeg therapy independent of their genetic makeup,¡¨ the authors wrote.

......

The authors suggest that the influence of IFNL4 diplotype status on molecular response may be due to the effect of ropeg treatment on JAK2V617F burden, the mutation that drives most cases of PV.

......

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Society of Hematologic Oncology (SOHO) 2020: Bringing ¡¦MPN Awareness¡¦ to Hematology Community

Ruben A Mesa, MD • Hematologic Oncology, Myeloproliferative Disorder

Hematology-Oncology Sep 21, 2020

opmed.doximity.com/articles/soho-2020-bringing-mpn-awareness-to-hematology-community?_csrf_attempted=yes

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www.aoporphan.com/de_de/unser-unternehmen/newsroom/mpn-awareness-day

2. ¨I±I³\¤[¡K²×©ó¦b9/10ªºSOHO¦~·|¤W, ¬Ý¨ìUSA Ruben ¤]¤Þ­z¸q¤j§Q­«¶q¯Å¦å²G¾Ç±Ð±ÂTiziano Barbui³Õ¤h¦b6¤ë¥÷ªºµoªí (6/15 6446©xºô¦³Â½Ä¶)

Society of Hematologic Oncology (SOHO) 2020: Bringing ¡¦MPN Awareness¡¦ to Hematology Community opmed.doximity.com/articles/soho-2020-bringing-mpn-awareness-to-hematology-community?_csrf_attempted=yes Ruben A Mesa, MD • Hematologic Oncology, Myeloproliferative Disorder

Hematology-Oncology Sep 21, 2020

SOHO helped make it clear there is great progress in the management of MPNs,

and that the pipeline of new therapies is robust!........

INTERFERONS: Highlighting some key themes, I would first want to focus on the increasingly important role of long-acting interferons and how they might alter the treatment of essential thrombocythemia (ET) and polycythemia vera (PV). The provocative findings(±Òµo©Êªºµo²{), presented at EHA 2020 by Prof Barbui, showed the superior benefits of Pegylated Interferon Alpha 2b (besremi, AOP Pharma Austria) vs. phlebotomy alone in low-risk PV for events and impact on PV symptoms and quality of life. These latter findings may well impact the traditional approach of solely aspirin and phlebotomy in low-risk PV.

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Stock price (lowest) 11.76 15.58 17.31 40.30 71.68 60.30 94.40 58.35 72.00 63.35

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¦pªGÀôÅU Incyte Jakafi ®Ö­ã¤W¥« for MPN MF °©Åè©ÊÅÖºû¤Æ (2011/11¤ë°_ºâ), ¾ú¦~ªº¦¬¤J, EPS, ¤ÎªÑ»ù°ª§CÂI¡K..¹ï¤ñ 6446 MPN PV ¬õ¦å²y¼W¥Í first line (2019/ 2¤ë)¤W¥««á, ªÑ»ù³Ì°ª175, ³Ì§C53.6¡K(·s«aªÍª¢¥þ²yªÑ¨a)¡K¬Æ¦Ü2-3«áÀ³¸Ó¤£Ãø¨ú±oET ¦å¤pªO¼W¥ÍªºÁ{§É¤T´Á¥¿­±µ²ªG»P2½u¥ÎÃÄÃÄÃÒ,..¨s³º¬O½ÖªÑ»ù°ª¦ô, ½Ö§C¦ô?

Jakafi is approved by FDA for MF first line drug in Nov/2011

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Product revenue (net) 2,012 136,001 235,443 357,562 601,015 882,404 1,200,312 1,466,900 1,774,922 987,017

product royalty revenue 3,652 28,251 48,966 74,821 110,711 160,791 234,780 306,337 174,533

Contract revenue 91,948 156,948 91,047 104,857 77,857 112,512 175,000 180,000 77,500 95,000

Other revenue 495 458 206 110 58 92 113 203

Total revenue 94,455 297,059 354,947 511,495 753,751 1,105,719 1,536,216 1,881,883 2,158,759 1,256,550

EPS (basic) (1.49) (0.34) (0.56) (0.29) 0.04 0.55 (1.53) 0.52 2.08 (1.98)

EPS (diiluted) (1.49) (0.34) (0.56) (0.29) 0.03 0.54 (1.53) 0.51 2.05 (1.98)

Stock price (highest) 20.36 26.15 52.23 66.51 133.62 105.28 153.15 102.63 95.45 110.25

Stock price (highest) 11.76 15.58 17.31 40.30 71.68 60.30 94.40 58.35 72.00 63.35

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¥D¤å: ¯f¤ÍGizem Arici Rerat:

Hello all

I just got news from my doctor that Roche is taking Pegasys off the market in Switzerland starting mid 2021. It seems Germany follows as well, but in 2022. Anybody else heard/read the news?

¤j®a¦n¡A§ÚªºÂå®v­è­è±µ¨ìù¤óªº³qª¾¡A¥L­Ì§Y±N¦b2021¦~¤¤±NPegasys±q·ç¤h¤U¬[¡CÅ¥¥Lªº·N«ä¦n¹³¼w°ê¤]·|¤@°_¤U¬[¡A¦ý¥i¯à·|¬O¦b2022¦~¡C½Ð°Ý¦U¦ì¦³¦¬¨ìÃþ¦üªº®ø®§¶Ü?

¦^ÂÐ: ¯f¤ÍAngie Zhu

Yes. It is for sure that within 5 years pegasys is off completely. Still not known which drug will replace peg, i hope it will be besremi. I dont see what else could it be

¬Oªº¡CµL±e¸mºÃPegasys·|¦b¤­¦~¤º§¹¥þ°±²£¡C¦ýÁÙ¤£¯à½T©w·|¬O­þºØÃĪ«·|¨ú¥N, ¦ý§Ú§Æ±æ¬OBesremi(ÃĵؤzÂZ¯À), ´N§Úªº²z¸Ñ§Ú¤£ª¾¹DÁÙ¦³­þ­ÓÃįà¨ú¥N¡C

¦^ÂÐ: ¯f¤ÍGizem Arici Rerat:

Thanks for the reply!

Not familiar with besremi, is that for PV or ET or both?

ÁÂÁ§Aªº¦^ÂÐ!

§ÚÁÙ¹ïBesremi¤£¤Ó¼ô±x¡A½Ð°Ý¬O°w¹ïPV¸òET¶Ü?

¦^ÂÐ: ¯f¤ÍLīga Pumpuriņa

im from Latvia. My hemo says that the first to get besremi would be the Pv patients. Maybe later it will be different.

§Ú¬O©Ô²æºû¨È¤H¡C§ÚªºÂå¥Í»¡PV¯f±w·|¥ý¨ü¨ìBesremiªºªvÀø¡A¦ý¥i¯à¹L¤@°}¤l·|§ïÅÜ¡C

¦^ÂÐ: ¯f¤Í Angie Zhu

besremi is for pv patients for now. But, it is the only drug with interferon on the market. Roferon- discounted, intron- discounted, pegasys-to be discounted. As all of patients that used roferon(standard ifn) later switched to pegasys, i assume (i hope) that pegasys users would switch to besremi

Besremi ¥Ø«e¬O¶È°w¹ïPV¯f±w¡C¥Ø«e¥¿±`ªº¬yµ{¬O¥ý¥ÎRoferon(ªì¯Å¤zÂZ¯À)¡A¦ý¦]¬°¦­¨Ç°}¤l´N°±²£¤F¡A¥Ø«e¯f±w³£¬O¥ÎPegasys¡C§Ú²q¥H«áµ¥Pegasys°±²£«á´N·|Åܦ¨Besremi¤F¡C

¦^ÂÐ: ¯f¤ÍBonnie Hawes Braun

I think the new one Besremi will replace it. Interferon is not being used like it was previously so not a profit for the Big Pharma! MS, HepC etc all have new better drugs, HepC has a cure.

§Ú»{¬°·s¤@¥NªºBesremi·|´À¥N¥Ø«eªº¤zÂZ¯À¡C ¦]¬°Â¦³ªº¥«³õ¦³³vº¥ÁY¤pªºÁͶÕ(¥H«eªº¤zÂZ¯À¬O±MªùªvÀøC¨x)¡C

¦^ÂÐ: ¯f¤ÍTiffani Gerbode

Possibly they feel that due to Ropeginterferon being proven to be somewhat better with less side effects, it wouldn¡¦t be able to compete? Don¡¦t know...that¡¦s unfortunate though.

Ãļt­Ì¥i¯àı±o¦]¬°Ropeg(BESREMI)¤w¸g³QÃÒ©úÀø®ÄÀu©ó¥L­ÌªºÃÄ¡C

¥H¤U¬O¯f¤Í¹ÎÅ骺¹ï¸Ü¡A´£¨Ñ¦U¦ì§ë¸ê¥ý¶i°Ñ¦Ò¡I¦^ÂÐ: ¯f¤ÍMecky Rennebaum-González

I heard about this last year. I¡¦m not sure whether this is the reason but I heard there are now newer and better drugs to treat Hepatitis (presumably Pegasys¡¦s primary application) and here in Switzerland I¡¦m using Pegasys off label. To produce Pegasys for only a - comparatively- small group of patients probably doesn¡¦t make sense economically.

Just out of curiosity - is Pegasys an off-label drug for PV in other countries as well?

§Ú¥h¦~´NÅ¥¹L¤F¡A§Ú¤£ª¾¹D¬O¤£¬O¦]¬°¥Ø«eC¨x¤w¸g¦³§ó¦nªºÃÄ¡C¥Ø«e¦b·ç¤hPegasys¬O¥Î¥é³æ¥~¨ú±o¡A¤S©ÎªÌ¬O¦]¬°¥Í²£³o­ÓÃÄ¥u¬°¤F³o¤@¤p¸s¯f¤H¡A¤£²Å¦X¸gÀٮįq?

¦^ÂÐ: ¯f¤Í Ken Gravenor

I think Ropeginteferon is already available in EU isn¡¦t it? Likely will be available in US soon too. Besremi will be indicated for PV treatment, unlike pegasys.

¥Ø«eRopeg(BESREMI)¦b¼Ú¬w¤w¥i¥H¨ú±o¡C¬Û«H¦b¬ü°ê¤]§Y±N¥i¥H¤F¡CBesremi·|¬O±Mªù°w¹ïPVªvÀøªºÃÄ¡A¤£¹³Pegasys¥u¯à±q¥é³æ¥~¨ú±oÃĪ«¡C

¦^ÂСG¯f¤ÍMecky Rennebaum-González

Yes, it¡¦s been available in Germany since last year September, I think, and it looks like it just became available in Switzerland last month.

¬OªºKen¡ABESREMI¥h¦~¤E¤ë´N¤w¸g¦b¼w°ê³Q®Ö­ã¡A¬Ý°_¨Ó¤W­Ó¤ë·ç¤h¤]®Ö­ã¤F¡C

¦^ÂÐ: ¯f¤ÍIda Ida Ken Gravenor

I take Besremi 14 month and I have PMF CALR + no PV....Iive in Austria

Ken, §Ú¤w¸gªA¥ÎBESREMI 14­Ó¤ë¤F¡A§Ú¬OPMF¨Ã¤£¬OPV¡A§Ú¦í¦b¶ø¦a§Q¡C¡]¸Ó¯f¤Í¬O¥é³æ¥~¨ú±o¡^

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