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ILC 2019: First-in-class entry inhibitor bulevirtide (Myrcludex B) effective and well tolerated in combination with PEG-IFN-a in Phase 2b study involving individuals with chronic hepatitis B/D virus coinfection, producing high rates of viral suppression both on and off treatment with good tolerability

13 April 2019, Vienna, Austria

ilc-congress.eu/press-release/bulevirtide-shows-promise-in-the-treatment-of-chronic-hepatitis-b-d-hbv-hdv-coinfection/

¤å¤¤©Ò­z ¬OÁp¦Xpeg-interferon-£\ 2a , ÃĵجOpeg-interferon-£\ 2b (?)

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The comparison of the efficacy of pegylated interferon £\-2a and £\-2b in chronic hepatitis B patients.

Dogan UB1, Golge N, Akin MS.

www.ncbi.nlm.nih.gov/pubmed/23652913

RESULTS:

Six of the 24 (25%) patients treated with Peg-IFN£\-2a versus eight of the 27 (29.6%) patients treated with Peg-IFN£\-2b achieved an SVR (P=0.75). HBeAg seroconversion occurred in three patients only in the Peg-IFN£\-2b group. Rates of patients with undetectable HBV-DNA at 24 weeks after a 48-week course of therapy were 20.8% for Peg-IFN£\-2a and 22.2% for Peg-IFN£\-2b (P=0.82).

CONCLUSION:

In CHB, there were no significant differences between Peg-IFN£\-2a and Peg-IFN£\-2b treatment groups in achieving an SVR and undetectable HBV-DNA levels.

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