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·|­û¡G°¶¤j¤j10136951  µoªí®É¶¡:2016/7/27 ¤U¤È 10:27:15²Ä 462 ½g¦^À³
¯ÂºéBlood´Á¥Z¦Ó¨¥¡A§Ú±qºô¯¸¨ú±o¡A(¦³ªº¬O¥H«e¦³¤j¤j¤w¸gPO¹Lªº¤å)¡A

¦³Ãöp1101ªvÀøpv´N¦³³o»ò¦hªº¤å³¹¡A³o»ò¦h¦Wªº¾ÇªÌ±M®aÂå®v­I®Ñ¡AÃÄÃÒµ´¹ï¬O¤â¨ì¾à¨Ó¡C

http://www.bloodjournal.org/content/early/2015/08/10/blood-2015-04-637280?sso-checked=true

http://www.bloodjournal.org/content/126/15/1762

http://www.bloodjournal.org/content/early/2015/08/10/blood-2015-04-637280

http://www.bloodjournal.org/content/early/2015/08/10/blood-2015-04-637280

Ropeginterferon alfa-2b, a novel IFN£\-2b, induces high response rates with low toxicity in patients with polycythemia vera

http://www.bloodjournal.org/content/126/23/4056

Long Term Efficacy and Safety Results and Analysis of Dose Correlations from the Phase I/II Peginvera Study of Ropeginterferon Alfa-2b, a Novel IFNa-2b, in Polycythemia Vera Patient

http://www.bloodjournal.org/content/122/21/4046

Efficacy and Safety Of AOP2014/P1101, a Novel, Investigational Mono-Pegylated Proline-Interferon Alpha-2b, In Patients With Polycythemia Vera (PV): Update On 51 Patients From The Ongoing Phase I/II Peginvera Study

http://www.bloodjournal.org/content/122/21/1611

AOP2014/P1101, a Novel Peg-Proline-Interferon Alpha (IFNa) 2b, Specifically Targets JAK2V617F-Positive Polycythemia Vera (PV) Cells

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§ÚªºÀt®§¤jªk

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«Ü¦h¬O´²¤á¡A¨S½m¹LÀt®§¤jªk¡A¤@¶^´NºÆ¨g±þ¥X¡AºCºCªº³Ñ¤U³o¤@¨Ç¦Ñ³¾¡A

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«H¤ß¤Q¨¬ ¥þ¤O®¼¶i

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608390/

¼ÐÃD:

P1101( Ropeginterferon alfa-2b)

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°ê¤ºªº¨x¯f®õ¤æ²ø¸UÀs¡B³¯©w«Hµ¥¤j©@¡A³Ìªñ¦b¨È¤Ó·|ij¤W¡A¤]°µ¥XÃþ¦Pªº³ø§i»P¥@¬É¥«­±¤W³Ì¦nªº¤zÂZ¯ÀPK§ó±`®Ä¡B°Æ§@¥Î§ó¤Ö¡C

³Ìªñ¼Ú¬ü¤é½Ñ¤j®vµ¸Ã¶©ó³~¡A¬Æ¦Ü»P¥_¨Ê³Ì¤j¹êÅ礽¥q¤§Ã±­q¦X¬ù¡C³oªí¥Ü¤j®a¬Ý¨ì¦nªF¦è¡A¤~·|¦p¦¹¤£Ãã¤d¨½­|­|¡C

¨ú±oÃÄÃÒ¦³µÛµ´¹ï«H¤ß¡A¤]§Æ±æ¦b¼Ð¥Ü¤W¯à¨ú±o§ó¦nªº±ø¥ó¡C

¦ý¤]§Æ±æ¤½¥q¸}¨B¯à¥[§Ö¡A¦]¬°­è¨úªºªÑ²¼ªº´²¤á¡A¹ï¥Í§Þ·sÃĬãµo¤£¼ô±x¡AÁ`¬O¤Ö¤@¨Ç­@¤ß¡C

Blood. 2015 Oct 8; 126(15): 1762¡V1769.

Prepublished online 2015 Aug 10. doi: 10.1182/blood-2015-04-637280

PMCID: PMC4608390

Ropeginterferon alfa-2b, a novel IFN£\-2b, induces high response rates with low toxicity in patients with polycythemia vera

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