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¯ÂºéBlood´Á¥Z¦Ó¨¥¡A§Ú±qºô¯¸¨ú±o¡A(¦³ªº¬O¥H«e¦³¤j¤j¤w¸gPO¹Lªº¤å)¡A ¦³Ãöp1101ªvÀøpv´N¦³³o»ò¦hªº¤å³¹¡A³o»ò¦h¦Wªº¾ÇªÌ±M®aÂå®vI®Ñ¡AÃÄÃÒµ´¹ï¬O¤â¨ì¾à¨Ó¡C http://www.bloodjournal.org/content/early/2015/08/10/blood-2015-04-637280?sso-checked=true http://www.bloodjournal.org/content/126/15/1762 http://www.bloodjournal.org/content/early/2015/08/10/blood-2015-04-637280 http://www.bloodjournal.org/content/early/2015/08/10/blood-2015-04-637280 Ropeginterferon alfa-2b, a novel IFN£\-2b, induces high response rates with low toxicity in patients with polycythemia vera http://www.bloodjournal.org/content/126/23/4056 Long Term Efficacy and Safety Results and Analysis of Dose Correlations from the Phase I/II Peginvera Study of Ropeginterferon Alfa-2b, a Novel IFNa-2b, in Polycythemia Vera Patient http://www.bloodjournal.org/content/122/21/4046 Efficacy and Safety Of AOP2014/P1101, a Novel, Investigational Mono-Pegylated Proline-Interferon Alpha-2b, In Patients With Polycythemia Vera (PV): Update On 51 Patients From The Ongoing Phase I/II Peginvera Study http://www.bloodjournal.org/content/122/21/1611 AOP2014/P1101, a Novel Peg-Proline-Interferon Alpha (IFNa) 2b, Specifically Targets JAK2V617F-Positive Polycythemia Vera (PV) Cells |
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«H¤ß¤Q¨¬ ¥þ¤O®¼¶i http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4608390/ ¼ÐÃD: P1101( Ropeginterferon alfa-2b) ªvÀø¬õ¦å²y¼W¥Í¯g(PV) §C¬r©Ê °ªÀø®Ä ³o¬O¤G´Á¹êÅçµ²§ô«á¡A¥h¦~10¤ë8¤éµoªí©ó¥@¬É³Ì«n´Á¥ZBloodÂø»xªº¤å³¹ ¨Æ¹ê¤W¡A±q2013¦~³sÄò¤T¦~³o¤@¨Ç¼Æ¤Q¦ì¬ì¾Ç¡A¤w¸g³sÄò¤T¦~¦b¥@¬É³Ì«nªº¦å²GBlood´Á¥Z¡AÃþ¦üµ²ªGªº¤å³¹¡C °ê¤ºªº¨x¯f®õ¤æ²ø¸UÀs¡B³¯©w«Hµ¥¤j©@¡A³Ìªñ¦b¨È¤Ó·|ij¤W¡A¤]°µ¥XÃþ¦Pªº³ø§i»P¥@¬É¥«±¤W³Ì¦nªº¤zÂZ¯ÀPK§ó±`®Ä¡B°Æ§@¥Î§ó¤Ö¡C ³Ìªñ¼Ú¬ü¤é½Ñ¤j®vµ¸Ã¶©ó³~¡A¬Æ¦Ü»P¥_¨Ê³Ì¤j¹êÅ礽¥q¤§Ã±q¦X¬ù¡C³oªí¥Ü¤j®a¬Ý¨ì¦nªF¦è¡A¤~·|¦p¦¹¤£Ãã¤d¨½||¡C ¨ú±oÃÄÃÒ¦³µÛµ´¹ï«H¤ß¡A¤]§Æ±æ¦b¼Ð¥Ü¤W¯à¨ú±o§ó¦nªº±ø¥ó¡C ¦ý¤]§Æ±æ¤½¥q¸}¨B¯à¥[§Ö¡A¦]¬°è¨úªºªÑ²¼ªº´²¤á¡A¹ï¥Í§Þ·sÃĬãµo¤£¼ô±x¡AÁ`¬O¤Ö¤@¨Ç@¤ß¡C Blood. 2015 Oct 8; 126(15): 1762¡V1769. Prepublished online 2015 Aug 10. doi: 10.1182/blood-2015-04-637280 PMCID: PMC4608390 Ropeginterferon alfa-2b, a novel IFN£\-2b, induces high response rates with low toxicity in patients with polycythemia vera |
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