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ÃÒ¥æ©Ò«¤j°T®§¤½§i (6446)ÃĵØÃĤ½§i¥»¤½¥q¦V¬ü°êFDA¥Ó½ÐP1101¥Î©óªvÀø¯u©Ê¬õ¦å²y¼W¥Í¯g(Polycythemia Vera)¤§²Ä¤T´ÁÁ{§É¸ÕÅç¡A¤wÀòFDA®Öã¡C 1.¨Æ¹êµo¥Í¤é:103/07/21 2.¤½¥q¦WºÙ:ÃĵØÂåÃĪѥ÷¦³¤½¥q 3.»P¤½¥qÃö«Y(½Ð¿é¤J¥»¤½¥q©ÎÁpÄݤ½¥q):¥»¤½¥q 4.¬Û¤¬«ùªÑ¤ñ¨Ò(Y«e¶µ¬°¥»¤½¥q¡A½Ð¶ñ¤£¾A¥Î):¤£¾A¥Î 5.µo¥Í½t¥Ñ:¥»¤½¥q¦V¬ü°êFDA¥Ó½ÐP1101¥Î©óªvÀø¯u©Ê¬õ¦å²y¼W¥Í¯g(Polycythemia Vera)¤§²Ä¤T´ÁÁ{§É¸ÕÅç(IND½s¸¹119047)¡A¤wÀòFDA¥¿¦¡³qª¾¥i«öpµe¶i¦æ(¥ç§Y¬ü°êFDA®Öã±µ¨ü¦b¼Ú¬w¶i¦æ¤§²Ä¤T´ÁÁ{§É¸ÕÅçpµe)¡C 6. ¦]À³±¹¬I:¶i¦æ¤½§i¡C 7.¨ä¥LÀ³±Ô©ú¨Æ¶µ: (1)¥»¤½¥q«e©ó102¦~9¤ë26¤é»P¬ü°êFDA¶i¦æPre-IND meeting¡A·|¤¤FDA©xû«Øij¥»¤½¥q¥i¿ï¾Ü¶È¥H¦b¼Ú¬w¶i¦æ¤§PROUD-PV trail(§YP1101¥Î©óªvÀø¯u©Ê¬õ¦å²y¼W¥Í¯g²Ä¤T´ÁÁ{§É¸ÕÅç)¼Æ¾Úµ²ªG¡A³w°e¬ü°êFDA¥Ó½ÐÃÄÃÒ¡C (2)PROUD-PV trail«Y¥»¤½¥q±ÂÅv(Out-Licensing)¹Ù¦ñAOP¤½¥q¦b¼Ú¬w¶i¦æ¤§²Ä¤T´ÁÁ{§É¸ÕÅç¡F¸g»PAOP¤½¥q¨ó°Ó«áij©w¡A¥Ñ¥»¤½¥q©e°UAOP¤½¥q¾á¥ôCROÅU°Ý¡A¨ó§U¬ü°êIND¥Ó½Ð°e¥ó¨Æ©y¡C
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·|û¡G¤pªÑªF10143235 µoªí®É¶¡:2017/1/12 ¤W¤È 09:55:27²Ä 1863 ½g¦^À³
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±q«e¦³¤@Ó¨ì³B³£¬OµU¤l¦a¤è¡A¤@¦W¨k¤l¥X²{¦V§ø¥Á«Å¥¬¡A¥L±N¥H¨C°¦ 10 ¤¸ªº»ù¿úÁʶRµU¤l¡C§ø¥ÁÁA¸Ñªþªñ¦³«Ü¦hµU¤l¡A¥L̨«¶i´ËªL¶}©l§ìµU¤l¡C ¸Ó¦W¨k¤lªá¤F¼Æ¤d¬ü¤¸ÁʶR¨C°¦ 10 ¤¸ªºµU¤l¡AµU¤l¼Æ¶q¶}©l´î¤Ö¡A§ø¥Á̶V¨Ó¶VÃø§ì¨ì¡A¦]¦¹¥L̤£¦A¼ö°J¤F¡C ¸Ó¦W¨k¤lÀH«á«Å¥¬¡A¥L±N¥X»ù¨C°¦µU¤l 20 ¬ü¤¸¡C³o¤SÅý§ø¥ÁÌ«·s¶}©l§V¤O§ìµU¤l¡C¦ý«Ü§Ö¨ÑÀ³¶q§ó¬°´î¤Ö¡A¥LÌ´X¥G«ÜÃø¦A§ì¨ì¤F¡A¦]¦¹¤H̶}©l¦^¨ì¦Û¤vªº¹A³õ¡A²H§Ñ¤F§ìµU¤l³o¥ó¨Æ¡C ¸Ó¦W¨k¤l¼W¥[»ù®æ¨ì¨C°¦ 25 ¬ü¤¸¡A¦ý¬OµU¤lªº¨ÑÀ³Åܱo§óµ}¤Ö¡A¦A«ç»ò§V¤O³£«ÜÃø¨£¨ì¤@°¦µU¤l¡A§ó§O½Í§ìµU¤l¤F¡C ¸Ó¦W¨k¤l²{¦b«Å¥¬¡A¨C°¦µU¤l¥L¥X»ù 50 ¬ü¤¸¡I µM¦Ó±q³o®ÉÔ¥LÂ÷¶}¤F¡A¥h«°¸Ì¿ì¤@¨Ç¨Æ°È¡A²{¦b¥Lªº§U¤â¥Nªí¥LÄ~Äò±q¨ÆÁʶRµU¤lªº·~°È¡C ³o¦W¨k¤lÂ÷¶}«á¡A§U²z§i¶D§ø¥Á¡AÁ@Á@¸Ó¦W¨k¤lÁʶR¦b¤jÅ¢¤l¸Ìªº³o¨ÇµU¤l¡A§Ú¨C°¦¥Î 35 ¬ü¤¸½æµ¹§AÌ¡Aµ¥¸Ó¦W¨k¤l±q«°¸Ì¦^¨Ó¡A§AÌ¥i¥H±N¥¦Ì¨C°¦ 50 ¬ü¤¸½æµ¹¥L¡C §ø¥Á̶׶°¤F©Ò¦³ªº¿n»W¡AÁʶR¤F¥þ³¡ªºµU¤l¡C ¥Ḻq¦¹¦A¤]¨S¦³¨£¨ì³o¦W¨k¤l©M¥Lªº§U²z¤F¡C §ø¤l¸Ì¤S¦A¦¸Åܦ¨¨ì³B³£¬OµU¤lªº¦a¤è¡C -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- ªÑ¥«¦h¤¿ÀI¡A¤d¸U¤£n¥u¦³§ø¥Áªº¹ê¤O¡A«o¦Û»{¬O¥ýª¾¡C ¶^¯}150ÀV½u¤ä¼µ¡A¤p¤ß°±·l½æÀ£±þ¥X¡C |
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·|û¡G¤p¥¿¥¿10141351 µoªí®É¶¡:2017/1/11 ¤U¤È 11:20:57²Ä 1862 ½g¦^À³
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¤@¡BHydroxyurea vs. Interferon https://mpnforum.com/round-one-title-fight/ ¤G¡BExpert takeaways from ASH (https://mpnforum.com/ash-2016-top-takeaways/) ¥~°ê¾ÇªÌ¹ïÃĵØÃÄP1101¬Ýªk(ºK¿ý)¡G ASH 2016 ¡V Top Takeaways by Top Doc John Mascarenhas, The PROUD-PV study showed that ropeginterferon is active and can induce clinical responses and may be better tolerated than Pegasys with less frequent dosing. Ruben Mesa, The PROUD PV Study was in patients with high risk polycythemia vera comparing Ropeginterferon vs. hydroxyurea. At a high level, what could be said is that the interferon and hydroxyurea were fairly similar through a year of follow-up in terms of control of blood counts, decreasing risk of blood clot or bleeding events and tolerability. Longer term follow-up on this study, which was presented suggested increasing number of molecular responses in the Ropeginterferon treated patients after a year. Brady Stein, ropeginterferon, administered each 2 weeks, proved non-inferior to HU with regard to efficacy. Personally, I was hoping for superiority. A similar caution was provided¡Xbest to wait until the data mature¡K¡K. Am I willing to accept HU as the best option for ET and PV? Not just yet. Richard T. Silver, Dr. Silver thought the results of the two HU and IFN trials were of interest but somewhat premature for an oral presentation at ASH. He wasn¡¦t surprised, not even at the molecular responses secured by HU. He had published on all that years earlier. He was only surprised that results were published at all after only one year Claire Harrison, Patients can enter PROUD PV for example if they had not responded to HU. This means there is potential for a bias in comparative results. However effectively these studies show equivalence of HU and IFN. |
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·|û¡G¤p¥¿¥¿10141351 µoªí®É¶¡:2017/1/11 ¤U¤È 11:02:08²Ä 1861 ½g¦^À³
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John Mascarenhas, MD, Mount Sinai Medical Center RESCUE open 2nd Q of 2017. Also shows HU is capable of inducing bone marrow pathologic responses and even molecular responses and this was somewhat surprising to many investigators. Longer term follow up will be essential to better distinguish true differences in tolerability and efficacy. The PROUD-PV study showed that ropeginterferon is active and can induce clinical responses and may be better tolerated than Pegasys with less frequent dosing. The pharmacokinetics of this agent are different than Pegasys due to the novel pegylation technology used to make the drug. This may in fact explain why the drug can be dosed less frequently and perhaps have better tolerability. Dr Gisslinger also presented data in which patients could effectively be transitioned from other forms of IFN to ropeginterfon safely and effectively in early PMF. So this looks like a potentially viable agent in MPNs and the MPD-RC is planning a trial called RESCUE which would allow patient that were receiving Pegasys on the MPD-RC 111 and 112 trials to transition onto ropeginterferon. This investigator initiated multi-center trial will hopefully open 2nd Q of 2017. |
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·|û¡GRussell10140734 µoªí®É¶¡:2017/1/11 ¤U¤È 10:57:15²Ä 1860 ½g¦^À³
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¬Ý¨ì¶Â¼v´N¶}ºj....Ãĵإi¯à³Q»~±þ¤F ºK¦Û.... ¼¶¤å / Á´I¦° ¥X³B / ¤µ©P¥Z 1047´Á ¥xÆW¥Í§ÞªÑ¤j¶^«áªº©ú¤Ñ¦bþ¸Ì¡H¥¼¨Óªº©ú¬P¬Oþ¨Ç¡H§Ú̦V¥Í§ÞªÑ§ë¸ê°ª¤â¡B©Ó¾PÀsÀY¨é°Ót³d¤H¡B°ê¤º«ü¼Ð©Ê¥Í§ÞªÑ°òª÷¸g²z¤H±´¸ß¡A¥L̵¹¤Fȱo°Ñ¦Òªºµª®×¡C ¡u§A²{¦b¨Ó§ä§Ú½Í¥Í§ÞªÑ§ë¸ê¡A®É¾÷«ê¨ì¦n³B¡A¦]¬°¯uªº¶^±o°÷ºG¤F¡I¡v´¿¸g¦b¨½©ù¡Bªk°ê¤Ú¾¤¡B¶×Â×µ¥¥~¸ê¨é°Ó¾á¥ô°ª¬ì§Þ²£·~¤ÀªR®vªºÄ¬½\²»¡A¨£¨ì°OªÌªº²Ä¤@¥y¸Ü¦p¦¹»¡¡C ¥|¦~¦h«e¡AÂ÷¶}¥~¸ê°é«á¡AĬ½\²»¦¨¥ß¦Û¤vªº§ë¸ê¤½¥q¡A±N¬Û·íµ{«×¤ñ«ªº¦Û¦³¸êª÷§ë¤J¦b¥Í§Þ²£·~¤W¡C°£¤F¥Í§Þ°òª÷Àò§Q¤£¿ù¥~¡A¥L¦b¨â¦ì¼ÆªÑ»ù®É§ë¸êªº¯E¹©¡A¥Hªñ¤T¦Ê¤¸¥X³õ¡A¤¤¸Î·sÃÄÀò§Q¥ç¥H¿¼Æp¡B«ù¦³¹O¥|¦~ªºÃĵØÃĨ´¤µ¤´«ùÄò¶R¶i¡A±b±Àò§Q¥iÆ[¡C (¤¤¶¡..²¤) «ö·Ó¥Í§ÞªÑ§ë¸ê°ª¤â¡A¤Î¥Í§ÞªÑªk¤HªºÅÞ¿è«ä±©¡A´M§ä¥xÆW¤U¤@ӥͧީú¬P¡AÀ³Âê©w±N¶i¤J¦¬³Î´Á¡A±q°l¹ÚÂà¶iÀò§Q½ñ¹ê¶¥¬q¤§¼Ðªº¡C§Ú̱q¦U®aªk¤H¾÷ºc°lÂܪº¥Í§Þ·sÃĪѡA§ä¥X¥¼¨Ó¤T¦~¤ºÀò§Q¸û¦³¾÷·|¤j´T¦¨ªøªº©ú¬P¤½¥q¡AÀ³ÄÝÃĵØÃÄ¡B´¼Àº¤Î°ª¶¥¾Ç¦WÃļt¥xÄ£µ¥¡C ÃĵØÃÄP1101¤µ¦~¶i¤JÃÄÃҥӽж¥¬q¡AY¤@¤K¦~¶¶§Q¥¬«Ø¾P°âºôµ¸¡A¤@¤E¦~¶i¤J¾P°ây¹D¡CªáºXÃÒ¨é¤ÀªR®v¨¦¤ë²[¦ôp¡AÃĵØÃĤ@¤E¦~±Nº«×¥X²{Àò§Q¡Aµ|®§«e§Q¼í¡]EBIT¡^¦ô¹F¤K¡D¤»»õ¤¸¥x¹ô¡A¤G¡³¦~±N¦¨ªø¦Ü¤G¤Q»õ¤¸¡A¤§«á³v¦~¥i±æéw¦¨ªø¡C¥Ø«e¨é°Óµ¹ÃĵØÃĥؼлù¸¨©ó¤G¤T¡³¤¸¦Ü¤T¤¡³¤¸°Ï¶¡¡C ¦P¤@¥»Âø»x...¹ï¯E¹©¸ò¤¤¸Î¦h¦³§å§P... ¹ïÃĵØ..«o¦³¥¿µû¸ò´Á«Ý.... ¥[ªo§a!! |
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·|û¡G¤p¥¿¥¿10141351 µoªí®É¶¡:2017/1/11 ¤U¤È 10:13:05²Ä 1859 ½g¦^À³
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ù¤ó¬O§_°±²£PEGASYS? For weeks, following a short distribution breakdown this summer, MPN social media was buzzing with rumors that Genetech/Roche was planning to stop production of Pegasys. Ever since Gilead released its $100,000 miracle hepatitis C drug, Sovaldi, a major share of the market for Roche¡¦s Pegasys suddenly weakened. Would Genentech drop Pegasys altogether? After checking with home base in Basel Switzerland, a Genentech corporate spokesperson told MPNforum its parent company ¡§Roche has no plans to stop PEGASYS production in the near future.¡¨ |
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·|û¡GAnderson10143089 µoªí®É¶¡:2017/1/11 ¤U¤È 01:15:46²Ä 1858 ½g¦^À³
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ºCºCÁͪñ§Úªº¤¶¤J¥Ø¼Ð»ù150¡A¦³¦b©³³¡´ú¸Õ«Ø¥ß¸ñ¶H¡A155¥ª¥k¶}©lÆ[¹î¦ø¾÷¦Ó°Ê¡C |
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Âàz¤Í¤Hªº¹Ú¤¤±¡¹Ò ¬Y¦ì¸¹ºÙ°]¸g¤j®v¡A¥L¦Ñ¨©¥Î¦Û¤wªº¿ú¶R¥Í§ÞªÑ¡A¤£®Æ³Q¥L±oª¾«á³º³Q¨ä¯ä½|¤@¹y! |
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¶®ªê·s»D.....¥´Áy¤å °]«H¶Ç´C¸³¨ÆªøÁª÷ªe¦bÁy®Ñªí¥Ü¡A¤@¨Ò¤@¥ð³y¦¨¥ø·~¤ß¦Ç·N§N¡A¥x¶ì¶°¹Î¤£¦A§ë¸ê¥xÆW1¤ò¿ú¡C¥x¶ì¶°¹Î¦^À³¡A¤£²M·¡®ø®§¨Ó·½¡A¶°¹Î104¦~¨ì106¦~§ë¸ê¥xÆW1243»õ¤¸¡A»·¤ñ¤§«e¦h¡C ³o¨ö¤Hªº°]¸g´CÅéÁÙ¥i¥H¬Û«H¶Ü?? |
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¯B¶³Ãø½ª¤é ¬ì¾Ç¸ô¤W¬O¥Rº¡¬D¾Ô¡A¤]¥Rº¡¤£½T©w©Ê¡A¦pªG¥i¥H100%½T©w¡A ¨º¤£¬O§@°²¡A´N¬O¯«¤F¡C ©Ò¥H¹êÅç¹Lµ{¡A ¡§º©º©ªø¸ô °_¥ñ¤£¯à¥Ñ§Ú¡¨ ªø¤[¥H¨Ó§Ú¤@ª½¬Û«H¡A Ãĵؤ@ª½°í¦u¬ì¾Ç¾É¦Vªº¤å¤Æ¡A¤è¦V¬O¥¿½Tªº¡A §Ú¤]¬Û«H³o¤@¨Ç¬ì¾Ç®aªº¯à@¡C §Ú§ó¬Û«H³Ìªñ³o¤@¤Á¥u¬O¨º µu¼ÈÄƹLªº¤p¯B¶³¦Ó¤w! |
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·|û¡G°¶¤j¤j10136951 µoªí®É¶¡:2017/1/6 ¤U¤È 12:32:59²Ä 1846 ½g¦^À³
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¤£n¬Ý¨ì¶Â¼v´N¶Ã¶}ºj ³Ìªñ¦³¨Ç¤p´¡¦±¡A¦ý§Ú̳ÌÃö¤ßªº¬O: 1,³Ì²×¹êÅç¼Ð·Ç¬O§_¸g©x¤è®Öã? ¥²¶·©Ò¦³°ê®a³£¦P·N! 2, 12Ӥ몺µ²ªG,¬O§_¹F¼Ð? 3, ¥i§_AOP·Ç®É¤U(¤G¤ë)¥Ó½ÐÃÄÃÒ?¥ý¥H12¤ëªº¼Æ¾Ú°e¥X¡A¦p¦P´X¦~«eªº³]©w¡C ¦pªG·Ó¤WzSOP ¡A¼Ú·ù¤@©wn¥ýµ¹ÃÄÃÒ¡C¥u¬O¥i¯à·|°µ¤@¨Ç¨î¡C (ºK¦Û¤WÂd¤½¶}»¡©ú®Ñp.17: ¥»¤½¥qìÁ{§É¸ÕÅ窺³]p(¦WºÙ¬° PROUD-PV)¬O¥H±N¨Ó¥«Ô·³Ì¤j¤Æ¨Ó³]p¡A¥H¾¨§Ö¨ú±oÃÄÃÒ¬°Àu¥ý¦Ò¶q¡A©Ò¥H°²³]¼Æ¾Ú¤£¦pì«ü¼Ð¡A¥»¤½¥q·|¥ý±µ¨ü©ó¥é³æ¤¤ÁY´î¾AÀ³¯g¯f±w±Ú¸s¤§¤è¦¡¡Aª§¨ú P1101 ¤Î¦¤W¥«¡A¦P®É¦]¥Ø«eªº¡¨ Conti-PV¡¨¤´Äݬ°Ä~Äò¦A¶i¦æªºÁ{§É¸ÕÅç¡A©¹«á·|¦A¥Î§ó¦hªºÁ{§É¼Æ¾Úª§¨ú§ó¼s§óÀuªºÀø®Ä¡C) 4, 12Ó¤ë¹êÅç¬O1³Ó1©M;18Ó¤ë¤w¬OÂù³Ó;24¤ë(³Ñ¤£¨ì3Ó¤ë)¬O§_¯à§¹³Ó?¦pªG¦b¤¤ëºI¤î«e¡A¦A°e§¹³Ó¸É¥ó¡A¨ºµ´¹ï¬O®ð¶Õ¦pi¡C ³o¤@¦¸AOPªº¹êÅç»P¼ÖÆ[ªÌì¥ý·Q¹³¨ÃµL¤Ó¤j®t²§¡A¬Æ¦Ü§ó¦n: 1,°e¥ó®É¶¡¨ÃµL©µ»~¡A¼f®Ö®É¶¡¤]µL©µ»~¡A®ÖãÃÄÃÒªº®É¶¡¤]µL©µ»~¡C 2,¨â¦~ªº¸ê®Æ¤ñ¤@¦~§ó¸Ô²Ó¡A§ó¦³»¡ªA¤O¡C 3,¨Ì·Ó»¡©ú·|ªº®ðª^»P¬ã§P¡A¨â¦~ªºÃĮĤO»P°Æ§@¥Î®t²§©Ô¤j¡A¬Æ¦Ü¼Æ¾Ú·|¤ñì·Qªº¦n¡A·|§â¹ï¤â¥´w¡C ¤]½Ð´CÅ餣n¬Ý¨ì¶Â¼v´N¶Ã¶}ºj¡C |
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·|û¡G¤p¥¿¥¿10141351 µoªí®É¶¡:2017/1/6 ¤W¤È 07:11:11²Ä 1845 ½g¦^À³
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How Did Incyte¡¦s Jakafi Perform in the US? By Mike Benson Jan 5, 2017 4:52 pm EST Jakafi As discussed earlier, Incyte¡¦s (INCY) Jakafi is the only FDA-approved drug for the treatment of myelofibrosis and polycythemia vera, both of which are rare types of blood cancer. Incyte sells the drug on US markets and has entered a collaboration with Novartis (NVS) for the commercialization of the drug outside US markets. Incyte receives royalties for drug sales outside the US markets. During 3Q16, the revenues for Jakafi rose over 39% to $223.9 million as compared to $161.3 million in 3Q15 revenues. These revenues are reported from the sales in US markets. The increase in revenues is because of volume growth as well as price increases for the drug in 3Q16. |
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·|û¡G¦n¹B10137114 µoªí®É¶¡:2017/1/5 ¤U¤È 03:52:03²Ä 1844 ½g¦^À³
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µª®×¬O:CEO ®p°j¸ôÂà... ¯¬ºÖÃĵØ! ÃÒ¥æ©Ò«¤j°T®§¤½§i (6446)ÃĵØÃÄ-¤½§i¥»¤½¥q·s¥ô°õ¦æªø 1.¤HûÅܰʧO¡]½Ð¿é¤Jµo¨¥¤H¡B¥N²zµo¨¥¤H¡B«nÀç¹B¥DºÞ¤§¦WºÙ¡B°]°È¥DºÞ¡B·|p¥DºÞ¡B¬ãµo¥DºÞ¡B¤º³¡½]®Ö¥DºÞ©Î¶D³^¤Î«D³^¥N²z¤H¡^:°õ¦æªø 2.µo¥ÍÅܰʤé´Á:105/12/23 3.ÂÂ¥ôªÌ©m¦W¡B¯Å¾¤Î²¾ú:µL 4.·s¥ôªÌ©m¦W¡B¯Å¾¤Î²¾ú:ªL°êÄÁ¡A°õ¦æªø¡A±KĬ¨½¤j¾Ç³Õ¤h¾Ç¦ì¤Î±K¦è®Ú¤j¾Ç³Õ¤h«á¬ã¨s¡Cªð¥x«e¥ô¾¬ü°ê¦bBoston ªºBiogen ¤½¥q¬°³Ð·sÃĬãµo³Ð©l¤§¤@¨Ã¥ôp¹º¥D«ù¤H¡A¦b¤§«e©ó¬ü°êMonsanto-Searle¶°¹ÎÁ`³¡·s¬ì§Þ³Ð·s¤¤¤ß³Ð·sÃĬãµo³¡¸ê²`¬ã¨s±M®a¡CªL³Õ¤h¦b¬ü´Á¶¡´¿°Ñ»P©Î¥D¾É¦@¦³¤T¦¸·sÃÄÀò¬ü°êFDA®Öã¡C 5.²§°Ê±¡§Î¡]½Ð¿é¤J¡uÃ㾡v¡B¡u¾°È½Õ¾ã¡v¡B¡u¸ê»º¡v¡B¡u°h¥ð¡v¡B¡u¦º¤`¡v¡B¡u·s¥ô¡v©Î¡u¸Ñ¥ô¡v¡^:·s¥ô 6.²§°Êì¦]:¦]À³¤½¥q¥þ²y¸ó°ê©ÊªºÀç¹Bµ¦²¤¤Îµo®i¡A¨Ã¬°¨Ï¤½¥q®ü¤º¥~²Õ´¹B§@¤Î¸ê·½¾ã¦Xµo´§³Ì¤j®Ä¥Î¡A«Ø¥ß¥«³õÄvª§¤O¤Î´£¤É²£·~°ê»Ú¦a¦ì¡A¬G¥ô©R쵦²¤ªøªL°êÄÁ³Õ¤hÂà¥ô°õ¦æªø(CEO)¤@¾¡C 7.¥Í®Ä¤é´Á:106/01/01 8.·s¥ôªÌÁpµ¸¹q¸Ü:(02)2655-7688 9.¨ä¥LÀ³±Ô©ú¨Æ¶µ:µL¡C |
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·|û¡GAnderson10143089 µoªí®É¶¡:2016/12/26 ¤W¤È 10:13:04²Ä 1770 ½g¦^À³
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·|û¡G³Á§JªL10142093 µoªí®É¶¡:2016/12/25 ¤U¤È 11:34:59²Ä 1768 ½g¦^À³
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·|û¡GRussell10140734 µoªí®É¶¡:2016/12/25 ¤U¤È 10:23:13²Ä 1767 ½g¦^À³
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·|û¡G®ÇÆ[ªÌ10141545 µoªí®É¶¡:2016/12/25 ¤U¤È 03:13:46²Ä 1765 ½g¦^À³
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·|û¡GRussell10140734 µoªí®É¶¡:2016/12/24 ¤U¤È 01:05:40²Ä 1764 ½g¦^À³
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huang hsia¤j... ³o¤UÃø¤ÀªR¤F.... ´²¤á¸ò¤j¤á«ùªÑ¦P®É¼W¥[¡A¤¤¹ê¤á´î¤Ö.... ¸Û¤ßªº½Ð°Ý¤j¤j¦³¦ó°ª¨£?? |
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·|û¡G¤p¥¿¥¿10141351 µoªí®É¶¡:2016/12/23 ¤U¤È 10:56:28²Ä 1763 ½g¦^À³
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3 Biggest Risks for Incyte Corporation Pricing pressure from politicians(ºK¿ý¨ä¤@) Many biotech investors breathed a sigh of relief after the U.S. election in November. Democratic presidential candidate Hillary Clinton had promised to make high drug prices a major focus if she was elected. After Republican candidate Donald Trump won, fewer people worried about political pressure on biotechs and pharmaceutical companies to hold down drug prices. That sigh of relief might have been premature. President-elect Trump says that he doesn¡¦t "like what¡¦s happened with drug prices" and has promised to do something about the problem. One change that he would like to make is to allow Medicare to negotiate lower drug prices with drug companies. A 30-day supply of the 10-milligram dose of Jakafi currently costs around $11,000. If political pressures culminate in legislative changes that are adverse to drugmakers, Jakafi¡¦s price could go down -- and Incyte¡¦s shares would also. Assessing the risks As for what will happen in Washington with respect to drug pricing reform, it¡¦s a roll of the dice. There is some bipartisan support for allowing Medicare to negotiate drug prices. On the other hand, the presumptive nominee to head the Department of Health and Human Services, Rep. Tom Price (R-Ga.), has previously opposed the idea. Investing is all about risk versus reward. While Incyte certainly faces some risks, the potential for reward from this biotech stock appears great. I don¡¦t think Incyte will slow down anytime soon. (http://www.fool.com/investing/2016/12/17/3-biggest-risks-for-incyte-corporation.aspx?source=yahoo-2&utm_campaign=article&utm_medium=feed&utm_source=yahoo-2&yptr=yahoo) |
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·|û¡GArkuyi10143526 µoªí®É¶¡:2016/12/23 ¤W¤È 11:15:12²Ä 1762 ½g¦^À³
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·|û¡Ghuang hsia10143515 µoªí®É¶¡:2016/12/23 ¤W¤È 11:11:28²Ä 1761 ½g¦^À³
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¤~¾ã²z¤U §AÌ´N¶}©lÃhºÃn©¹¤U±¾ ¤~¶^´X¶ô´N¶}©l¥s §O·dºâ¤F »¡¦A¦h¡A¦³·N¸q¶Ü »¡¤F¡A²{ª÷ªÑ ¨ü¤£¤F´N½ß¿ú½æ¡A¥i¥H¯Ó´Nµ¥¥´©³ »¡¹L´N³oªþªñ¤F¤£¬O¶Ü §Ú¤£¦Aµo¤å¤F ·R«ç»ò¿ë§AÌ¿ë¥h§a §Úªº«ùªÑ¶}©l´N»¡¤£¦h ¹ï§Ú¨Ó»¡¼vÅT¤£¤j §Ú¯Âºé¤À¨É¦Û¤v·Qªk¦Ó¤w ¤j®a¦U¦Û¥[ªo§a ·R·d¬ã¨s´N¬ã¨s¥h ·R°ò¥»±´N°ò¥»±§a |
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·|û¡GAnderson10143089 µoªí®É¶¡:2016/12/23 ¤W¤È 11:07:42²Ä 1760 ½g¦^À³
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·|û¡Ghuang hsia10143515 µoªí®É¶¡:2016/12/23 ¤W¤È 08:43:49²Ä 1756 ½g¦^À³
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¤w¸g´£¿ô¹L¤F ·Pı¬å¤£¤Ó¤U¥h ½ÖÁÙ¦b¨º¸Ì»¡±Y½L¡H ¥L¦Û¤v³£±Ë¤£±o¬åµ¹¤j®aÀË«K©y ª÷¦r¶ð¬Oµ¹¤j³¡¤À¤£¤Ó·|¬ÝÄw½Xªº¤H¤j·§ÁA¸Ñ¤U Ãø¹DÄw½X´N¬O¤T¤jªk¤H¶R½æ¶W¡H´N³o¼Ë¡H ¬Oªº¸Ü¡A¤j®a³£·|°µªÑ²¼¤F ¨ä¥L¤£¦h»¡ ³o¸Ì¬O¤j®a°Q½×ªº¦a¤è ¨S¥²n§A¨Ó§Ú¥hªºª§ÅG ¤£»{¦P´Nºâ ¤£n§â§â¦r²´·dªº¤Ó¹L §Ú¥»¨Ó»¡¤£·Q¦A¦b³o¸Ì¦Aµoªí¥ô¦ó¨¥½× ¥»¨Ó¬O·QÀ°§U¤j®a »¡ªº¦n¹³·d¤°»ò¦üªº¡A§Ú¥i¨S¨º»ò¶~ ¥u¬O§Ú¬Ý¨ì¯d¨¥³£¦¨³o°Æ¼w¦æ ¦³¥²n³o¼Ë»¡¸Ü¶Ü¡H |
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·|û¡GRussell10140734 µoªí®É¶¡:2016/12/21 ¤U¤È 10:39:19²Ä 1755 ½g¦^À³
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by the way, huang hsia, thanks for your suggestion. Having checked the so-called ª÷¦r¶ð, I found an interesting thing that it is the stuff ªÑÅv¤À´²ªí. I do it every single week frequently, but by another way. |
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·|û¡GRussell10140734 µoªí®É¶¡:2016/12/21 ¤U¤È 10:18:55²Ä 1754 ½g¦^À³
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¤p¦ë§Q¤j ¬ðµM·Q¨ì....§A»¡¦pªG§A¬O¤jªø½uªº§ë¸êªÌ¡A§Ú»¡¹L¤F¡A¤£¶·n¦b¦¹½×¾Â¬yº§¡A¦]¬°§A®Ú¥»¤£¥Î¦b¥GªÑ»ù°ª»P§C §AÀ³¸Ó©ïÀY¬Ý¤@¤U ¼ÐÃD¤£¬Oªø´Á«ù¦³¥Ø¼Ð»ù500¤¸¥H¤W¶Ü?? ¬O§Ú¶]¿ùª©¤F?? «¢«¢... ¬Ýª©±ÅܧN²M¤F...¶}Óª±¯º^^ |
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·|û¡G¥ý¶i10000164 µoªí®É¶¡:2016/12/20 ¤U¤È 01:56:46²Ä 1753 ½g¦^À³
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Ãĵؤ£±N¯BÃB²M¬~°®²bµ´¤£µ½½}¥Ì¥ð¡AªÖ©wÅý´²¤á«r¤ú¤Á¾¦¡K¡K¡K¡K¡K ¦³«H¤ßªº¤â´¤«ùªÑ¡K¡K¡K©ñ»´ÃP¡A¤£¥h¬Ý½L¨S¨Æ¡K¡K¡K |
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·|û¡G¦B«B10138946 µoªí®É¶¡:2016/12/20 ¤U¤È 01:31:06²Ä 1752 ½g¦^À³
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·|û¡G¤ò¤p«Ä10143517 µoªí®É¶¡:2016/12/20 ¤W¤È 11:08:12²Ä 1751 ½g¦^À³
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Ãĵسo¬O¶^ÁÙºâ¬O¦³ÂI¼µ¤F¡A§Ú³o´X¤Ñ°±·lªº¤¤¸Î©M´¼Àº¦å¥Î¼Qªº¡A¥þ³£««ª½±a¶q«æ±þ¡CÓ¤H·Pı³o¸ò°ò¥»±¤°»òÃö«Y¡A·sÃĪѥþ±±a¶q«æ±þ¡A¯Âºé¬O¤j¤á¡Bªk¤Hn§â·sÃĪѸêª÷©â¥X¨Ó´«ªÑ¾Þ§@¡C¯uªºn¦³¹³¼Ëªº¦æ±¡¡A§Ú¬Oı±onµ¥¨ì©ú¦~Q4¤F¡A³Ì²z·Qªºª¬ªp¬O¤¤¸Î¶}©l¦³À禬¡B´¼ÀºEPS©ú¦~¥¿¦¡¯¸Ã10¥H¤W¡AÃĵض¶§Q®³¨ì¼Ú¬wÃÄÃÒ¥h¥Ó½Ð¬ü°êÃÄÃÒ¡A¤T°¦³£¯à¿Ä¸êú³´£°ª¶gÂà²v¡A¦A°t¦XÃD§÷ª£§@¤~¦³¤j¦æ±¡¾÷·|¡A²{¦b§Y«K¤Ï¼u³»¦h¤]´N¬O¶^²`¤Ï¼u¦Ó¤w¡C¤Ï¥¿¤@ªK¿W¨q¤£¬O¬K¡A¦Êªá»ô©ñ¬Kº¡¶é¡AÃþªÑ¤@¤ä¿W±j§xÃø«×«Ü°ªªº |
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·|û¡GAnderson10143089 µoªí®É¶¡:2016/12/20 ¤W¤È 11:02:41²Ä 1750 ½g¦^À³
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·|û¡GºÙ¤ß¦p·N10142058 µoªí®É¶¡:2016/12/20 ¤W¤È 10:52:41²Ä 1749 ½g¦^À³
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·|û¡GAnderson10143089 µoªí®É¶¡:2016/12/20 ¤W¤È 10:46:22²Ä 1748 ½g¦^À³
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·|û¡G¦V¿ú¨«10137837 µoªí®É¶¡:2016/12/20 ¤W¤È 10:23:57²Ä 1747 ½g¦^À³
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·|û¡G¤p¦ë§Q10143521 µoªí®É¶¡:2016/12/19 ¤U¤È 11:08:46²Ä 1746 ½g¦^À³
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Mr. Hsia, I think you probably go back to States for the XMAS holiday. I would like to say Merry Christmas to you here. I think your information and comment is very precious. Hope to hear from you soon. |
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·|û¡GRussell10140734 µoªí®É¶¡:2016/12/19 ¤U¤È 10:39:23²Ä 1745 ½g¦^À³
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¨CÓ¤H¦³¦Û¤vªº«H¥õ¡A¤£¥Î¤Ó¦b·N§O¤H«ç»ò»¡!! À³¸Ó»¡....¤£¥Î¦b·N§Ú«ç»ò»¡ ·|³o¼Ë¸ò¦U¦ì¤j¤j¤À¨É ¬O¥H«e¦³Ó«È¤á¡A¨C¤Ñ¥u°µ¤G¥ó¨Æ¡G¦¬¯²¸òª±ªÑ²¼ ©â±P¥´¶}º¡º¡ªº³£¬O¦L³¹¡A«O¦u¦ôp¤HÀY¤á¦Ü¤Ö´X¦ÊÓ(¥H«eÁÙ¤£¬y¦æ¹q¤l¥æ©ö) ¥ú©âÅÒ......§Ú̳£©â¤£Ä¹¥L ¨ä¥Lªº´N.... |
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·|û¡Ghuang hsia10143515 µoªí®É¶¡:2016/12/19 ¤U¤È 10:23:09²Ä 1744 ½g¦^À³
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fine, if this is what you want (R), i guess this would prob be last time i would ever post any comments up here. Go back to your basic research and gd luck! and for the rest of you, i would still recommend you guys to go check out ª÷¦r¶ð sometimes when you free. Xmas is coming, so happy holidays to all of you. |
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·|û¡GRussell10140734 µoªí®É¶¡:2016/12/19 ¤U¤È 10:12:42²Ä 1743 ½g¦^À³
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©Z¥ÕÁ¿... §Ú¬Oªø´Á§ë¸ê¡A¦ýµu½u½Õ¸`¤]°µ ¤â¤W¦³°ò¥»³¡¦ì¡A¦ý¥t¦³¤@³¡¥÷¶i¥X ¸Ó»{½ß»{½ß¡A¸Ó°l°ª´N°l.... ¤Ï¥¿¦³ÁȦ³½ß¡AÁȪº¤ñ½ßªº¦h´N¦n¤F ¥¼¨Ó¨«¶Õ....§Ú±q¤£¹w´ú ÁöµMªÑ»ù¬O¥Ñ¤Ö¼Æ¤H¨M©wªº¡A¦ý§Ú̪º¤l¼u¥Ã»·¨S¦³¥D¤O¦h Á¿¥Õ¤@ÂI....§Ų́S¦³Ä³»ùÅv¡A¬O»ù®æªº±µ¨üªÌ ¤Ï¥¿«S¾÷¦Ó°Ê¡A°µ¦n¦Û¤vªº°]°È³W¹º¸ò·ÀI±±ºÞ¡A¶¶¶Õ¦Ó¬°¡C ¦Ü©óÄw½X±¡A¦³®É¬Ý¬Ý´N¦n.... ¥ý«e´N»¡¹L¡A¦b¥xÆW¤HÀY¤á¤S¤£¥Çªk¡A¥D¤O¦³«Ü¦h °£«D¤½¥q¬£¦Û¤v°µ¦h¡AnÅý§A....²M·¡ªº¬Ý¨ì ¤£µM¥D¤O·|Åý§A¤ÀªRªº¥X¨Ó....¸ò¥L°Û¤Ï½Õ©Î·f¶¶·¨® ¤×¨ä¬O¤½¶}ªº½×¾Â¡AÁ¿Á¿°ò¥»±ÁÙ¥i¥H¡A¤½¶}Á¿Ó¤Hªº¾Þ§@±...¤j¥i¤£¥² °£«D§A´Û¼Ä....¨¥¤£¥Ñ°J ¦³¤H·|¬Ýªº |
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·|û¡Ghuang hsia10143515 µoªí®É¶¡:2016/12/19 ¤U¤È 09:52:37²Ä 1742 ½g¦^À³
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ª÷¦r¶ð¤j®a¥h¬Ý¬Ý§a §ÚÓ¤H·Pı®t¤£¦h´N³oªþªñ¤F ¦pªG¦LÃÒ¼Ó¤U»¡ªº ²ö¦W¨ä§®µ¹§A©¹¤UÄé¨ÓӼɶq ¦A¨Ó¦Ò¼{¤jªÑªFÌ¥X³f§¹²¦§a ¥D¤O¤Ñ¤Ñ¦bµ¹§A̵e½u µeªº¤ÓÃø¬Ý¤]¦n¡A¤Ó¨S¤]¦n Äw½X¨ÌµM·|§i¶D§A¥L¦b½æÁÙ¬O¦¬ |
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·|û¡G¤p¦ë§Q10143521 µoªí®É¶¡:2016/12/19 ¤U¤È 09:51:40²Ä 1741 ½g¦^À³
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©Ò¥Hù¯Àô§A¬OÁo©ú¤HÅo¡A´±°Ý¤jô¥¼¨Ó¨«¶Õ¡A¦ý¬O½Ð¤£n§i¶D§Ų́â¤T¦~«á¦^¨Ó¬Ý¤j®a³£¸Ñ®Mªº¸Ü¡A¦pªG§A¬O¤jªø½uªº§ë¸êªÌ¡A§Ú»¡¹L¤F¡A¤£¶·n¦b¦¹½×¾Â¬yº§¡A¦]¬°§A®Ú¥»¤£¥Î¦b¥GªÑ»ù°ª»P§C |
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·|û¡GRussell10140734 µoªí®É¶¡:2016/12/19 ¤U¤È 09:44:26²Ä 1740 ½g¦^À³
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½u¹ºªº¤£¿ù... ¥D¤O¦pªGÅý§A̲qªº¥X¨Ó...¥L´N¤£¥Î²V¤F ¹w¦ô³Ìªø¤@¦~«á¡B¦^ÀY¨Ó¬Ý¡A¤j®a³£¯º¤F ¥N»x¸òéw¤H·Qªº³£¤£¤@¼Ë |
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·|û¡Ghuang hsia10143515 µoªí®É¶¡:2016/12/19 ¤U¤È 09:38:18²Ä 1739 ½g¦^À³
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¥D¤O¥i¥H§â»ù®æ¬å¨ì«Ü§C §C¨ì²Å¦X¥L¤ß¥Ø¤¤²z·Q»ù¦ì ¦A§âÄw½X¦¬¦^¨Ó »ù®æ¤W¤W¤U¤U §A«nªº¬O§ì¦íÄw½Xªº¬y¦V§a¡H ¬°¦ó§âÄw½X¦¬¦^¨Ó¡H ¤£´N¬O¦]¬°Ä±±o»ù®æ¦X²z¡An¦A°µ»ù®t·d¤W¥h §Aı±o¥D¤OÁٯవ¤°»ò¡H ·íµM¡AÀ°¤jªÑªFÌ¥XªÑ²¼¤]¬O¥D¤Oªº¥Øªº ©Ò¥H§Ú¤~»¡ ¨n¦íÄw½Xªº¥h¦V§a |
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·|û¡Ghuang hsia10143515 µoªí®É¶¡:2016/12/19 ¤U¤È 09:29:06²Ä 1738 ½g¦^À³
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½Ö¸ò§A»¡n¤ñ¦¨¥»¡H »ù®æ¬O°ÝÃD¶Ü¡H Äw½X¤~¬O§a §Ú¤£¬O¤@ª½¦b«½Æ»¡ Äw½X¦¬¦^¨Ó¦A¨Ó½Í¤Ï¼u¡H ¥L¦¨¥»¦A§C¤]¦n ´X¸U±i¦b¨º¸Ì¡A§Aı±o¥L¯à¥Xµ¹½Ö¡H n¤£´N©Ô°ª©¹¤W¥X¡A¹³¯E¹© 2015/11/30¨ººØ¸U±iªº¶q¡AÁÙ¦³¤¤¸Î 2016/5/31ªº¸U±i¶q n¤£´N©¹¤UÄé¡A«e´£¬O¶q©O¡H ¨S¶q§A¬On¤jªÑªF˵¹½Ö«ô°U¡H |
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·|û¡G¤pªÑªF10143235 µoªí®É¶¡:2016/12/19 ¤U¤È 09:11:21²Ä 1737 ½g¦^À³
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¤jªÑªF©Mû¤u»{ªÑ¦¨¥»¥u¦³10¤¸¡AÁÙ¦³¨â¸U¦h±i¦¨¥» 0¤¸ªº§Þ³NªÑ¡An¸ò¤jªÑªF¤ñ¦¨¥» ----- §O³r¤F§a¡I |
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·|û¡Ghuang hsia10143515 µoªí®É¶¡:2016/12/19 ¤U¤È 08:37:38²Ä 1735 ½g¦^À³
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¦b¤Uè¦n¦³¨Æ¥X°ê´X¤Ñ ¤£¤è«K¤Î®É¬Ý½L ¯¬ºÖ¤j®a¦b¥¼¨Ó´X¤Ñ¾Þ§@³£¶¶§Q §ÚÓ¤H¬O¨S¥´ºân½æ¡A¦]¬°«ùªÑ¤£¦h §Ú¤]·Q¬Ý¬Ý³o³Ã¹Ù¯à·d¨ì¤°»ò¥÷¤W §Úªº¸gÅç§i¶D§Ú¡A³o¥uµ´¹ïÁÙ¨S±Ë±on±¾ ¦]¬°¤jªÑªF̳£µ´¹ï¨S¥X§¹³f¡I ±q°ªÂI¶^¤U¨Ó³Ì§CÂIªº´T«×¡A¤]ºâ¦X²zº}«G ¨S¦³Åý§Ú¬Ý¨ì¦³n±¾ªº¼Ë¤l ³o¥u¥unÄw½X¦u¦í¡A³°Äò¶°¤¤ ¹L 213¬O¥²µMªº |
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¨C¤Ñªº¦¨¥æ¶q ¦³¤@¥b¥ª¥k³£¬O¦Û¤v°µ¥X¨Óªº ¨ä¹ê½æ¶W±i¼Æ´N¨º¨Ç §Ú¤~·|»¡¡A·Pı½æ¤£¤Ó¤U¥h¤F ·íµM¡A¥H¥Ø«e¨C¤Ñ«ùÄò½æ¶Wª¬ªp¨Ó¬Ý §Ú¤£¯à»¡«OÃÒ¤£·|¯} 154 °ÝÃDÃöÁä¬O¡A¯}¤F154Äw½X¦³¨S¦¬¦^¨Ó ¦pªG¥u¬O¬å¨ì¤j®aÀ~¨ì¤ßŦ³£°±¤î¡A¥Øªº¥u¬°§â¦U¦ì¤â¤¤Äw½Xµ¹À~¥X¨Óªº¸Ü §ÚˬOı±oÁÙ¦n ¥L´±¬å´±¦¬¡AÃø¹DÁÙ¾á¤ß¥L¤£·d¤W¥h ¥D¤O¤]¬OnÁÈ»ù®tªº¡An¤£µM¨C¤Ñ½L³o»ò´e¡A¥L¯à·F¤°»ò¡H ¦n¯ºªº¬O¡A¤W¦¸§Ú¤~è´£¨ì´I¨¹¤j¦w³oÓ¤áÀY§C¶R°ª½æ ²ö¦W¨ä§®³o¦ì¤¯¥S´N¶}©l±q´I¨¹¤j¦w¬å ·|¬ÝÄw½Xªº¤H¡AÃø¹D¥u¬ÝªºÀ´´I¨¹¤j¦w³oÓ¤á¶Ü¡H ¬JµM¤j®a³£³Q®M¤F¡A¦Ó¥B³o¬O²{ª÷ªÑ ´N¤j®a¤@°_¦wÀRµ¥«Ý ¬Ý¬Ý³o¦ì¤¯¥Sn·F¹À ¤j®a½ßªº¤]¤£¹L¬O®É¶¡¡A¤£¬O¶Ü °£«D§AÌ¥ÌÄ@½æ±¼²{¦³«ùªÑ»{½ß n¤£¡A§Ú«Øij¤j®a¦wÀRªºµ¥«Ý ¬Ý¬Ý³o¦ì¤jôn¬~¨ì¦ó®É |
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²×©ó¬Ý¨ì¤j®a¶}©l°Q½×Äw½X§Þ³N±¤F ¦P·N±µ¤U¨Ó¤TÓ¤ë¡AÄw½X§Þ³N±¤ñ°ò¥»±§ó«n¡A¤]¦P·NH¤jµu´Á©³³¡´N¦b³oªþªñ¡A¦ýY¬O¦A¯}154ªº«e§C¡A¤£ª¾H¤jªº¬Ýªk¬°¦ó? ¤µ¤Ñ´N¤T¤jªk¤Hªº½æ¶W¶È¶È¤Q´X±i¡A¥i¬O¶q¶]¥X¤F¤K¦Ê¦h±i¡AÅãµM¥D¤OÁÙ¬O¦b˳f¡A³o¬O¤ñ¸ûºÃ¼{ªº; ¥t¥~¡A¬Ý¬Ý¦³°ò¥»±EPSÀò§Qªº´¼Àº«¶^¡A³o¤]¬O§Ú¤ñ¸û¾á¤ß·sÃĪѪº¥¼¨Ó¨«¶Õ¡A·Q½Ð±Ð¦U¦ìªº¬Ýªk |
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