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¤T¡B³æ¤@Á{§É¸ÕÅçµ²ªG(¥]§t¥D¡B¦¸­nµû¦ô«ü¼Ð¤§²Î­p¾Ç¤W¬O§_¹FÅãµÛ·N¸q)¡A¨Ã

¤£¨¬¥H¥R¤À¤Ï¬M¥¼¨Ó·sÃĶ}µo¤W¥«¤§¦¨±Ñ¡A§ë¸ê¤HÀ³¼f·V§PÂ_ÂÔ·V§ë¸ê¡C

¥|¡B¥¼¨Ó·sÃÄ¥´¤J¥«³õ­pµe

¼Ú¬w¦a°ÏªvÀø¯u©Ê¬õ¦å²y¼W¥Í¯g¤§¾P°âÅv±ÂÅv¤©AOP¤½¥q¡AAOP¤½¥q¥Ø«e¥¿¬°

P1101¥¼¨Ó¤W¥«§G«Ø¦æ¾P³q¸ô¡A¨Ì¾Ú±ÂÅv¦X¬ù¥»¤½¥q¦¬¨ú¾P°âÅv§Qª÷¤Î¥X°âÃÄ

«~¦¬¤J¡F¥»¤½¥q¬ü°ê¦a°Ï¨ÃµL±ÂÅv¥L¤½¥q¡A¹w­p©Û¶Ò¨ã¦³·sÃÄ¥«³õ¦æ¾P¸gÅç

¤§¤H¤~«Ø¥ß¹Î¶¤¡A¦Û¦æ«Ø¥ß¾P°â³q¸ô¡B´M¨Dµ¦²¤¹Ù¦ñ¶i¦æ¦X§@©Î¹ï¥~±ÂÅvµ¥

¤è¦V¡A¥H°l¨DªÑªFªø´Á³Ì¤jªºÅv¯q¬°¥Ø¼Ð¡C

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7.¨ä¥LÀ³±Ô©ú¨Æ¶µ:

¤@¡B¬ãµo·sÃĦWºÙ©Î¥N¸¹¡GP1101

¤G¡B¥Î³~¡GP1101«Y·s¤@¥Nªø®Ä«¬¤zÂZ¯ÀÃĪ«¡A²{¥¿¶i¦æ¥Î©óªvÀø¯u©Ê¬õ¦å²y¼W

¥Í¯g(PV)µ¥¤HÅéÁ{§É¸ÕÅç

¤T¡B¹w­p¶i¦æ¤§©Ò¦³¬ãµo¶¥¬q¡G¼Ú·ùEMA¥Íª«»s¾¯·sÃĬdÅçµn°O¥Ó½Ð(MAA)

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(¤@)´£¥X¥Ó½Ð/³q¹L®Ö­ã/¤£³q¹L®Ö­ã¡G·sÃÄP1101¥Î©óªvÀø¯u©Ê¬õ¦å²y¼W¥Í¯g

(PV)±wªÌªº¥þ²y©Ê²ÄIII´ÁÁ{§É¸ÕÅçPROUD-PV«á¦AÄ~ÄòÁ{§É¸ÕÅçIIIb

(CONTI-PV)¡A¦¹Á{§É¸ÕÅç¤D¬°¨ú±oªø´ÁÀø®Ä¤Î¦w¥þ©ÊªºÁ{§É¼Æ¾Ú¡A¹w­p

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·ùÃĪ«ºÞ²z§½(EMA)´£¥XÃÄÃҥӽСA¥Ø«e¥¿¦b¼f²z¤¤¡C

ºô­¶¡Gclinicaltrials.gov/ct2/show/NCT02218047?term=AOP2014&rank=3

(¤G)¥¼³q¹L¥Øªº¨Æ·~¥DºÞ¾÷Ãö³\¥iªÌ¡A¤½¥q©Ò­±Á{¤§­·ÀI¤Î¦]À³±¹¬I¡G¤£¾A¥Î

(¤T)¤w³q¹L¥Øªº¨Æ·~¥DºÞ³\¥iªÌ¡A¥¼¨Ó¸gÀç¤è¦V¡G¤£¾A¥Î

(¥|)¤w§ë¤J¤§²Ö¿n¬ãµo¶O¥Î¡GCONTI-PV©ó¼Ú¬w¶i¦æÁ{§É¸ÕÅç¶O¥Î¥Ø«e¼È¥ÑAOP

¤½¥q¥ý¦æ¤ä¥I¡C

¤­¡B±N¦A¶i¦æ¤§¤U¤@¬ãµo¶¥¬q¡G

·sÃÄP1101¥Î©óªvÀø¯u©Ê¬õ¦å²y¼W¥Í¯g(PV)±wªÌªº¥þ²y©Ê²ÄIII´ÁÁ{§É¸ÕÅç

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡GªÅ¤]ªÅªÅ10145331  µoªí®É¶¡:2017/12/11 ¤W¤È 07:38:49²Ä 3231 ½g¦^À³
CONTI-PVªºµ²ªG½T¹ê¤£¿ù¡A

¸ÕÅ窺«~½è¦pªG¤]±o¨ìFDAªº»{¥i(¨Ò¦p¡A¸ÕÅç²Õ»P¹ï·Ó²Õªº¤H¤f¾Ç(demography)¸ê®Æ¬Û·í¡K)¡A

³o­Óµ²ªG«Ü¦³¥i¯à¼g¤J¥é³æ(lable)¡F

¦pªG¯u¼g¤J¥é³æ¡A¨ºZimmerman¤j»¡ªº¡G

¡¨a valuable, long-term first-line treatment option for PV¡¨¡A

³o¥y¸Ü³Q¯f±w¡BÂå¬É¤Î«OÀI·~±µ¨üªº¸ô¡AÀ³¸Ó´N·|¥­©Z³\¦h¡A¤£¦Ü©ó¥Rº¡¯ð´Æ¡C

Craig Zimmerman, PhD, Vice President Operations, PharmaEssentia USA, added, that

these substantial results go beyond our phase III study findings at 12 months to further

validate Ropeginterferon alfa-2b as a valuable, long-term first-line treatment option for PV,

which affects more than 100 thousand people in the U.S alone.

We look forward to providing updates and next steps for PharmaEssentia¡¦s submission of a BLA to the FDA.

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡GAnderson10143089  µoªí®É¶¡:2017/12/11 ¤W¤È 06:51:13²Ä 3230 ½g¦^À³
§Æ±æ¤£·|¤S¬O¶}°ª¨«§C....
¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡GµLµß®ñ10021927  µoªí®É¶¡:2017/12/10 ¤U¤È 10:42:17²Ä 3229 ½g¦^À³
JAK°ò¦]¬ðÅÜ»P¯e¯f

JAK1¦bSH2¤ÎJH2 domain¬ðÅܮɡA·|¾É­P¿©±w«æ©Ê°©ÀH¥Õ¦å¯f (Acute myeloid leukemia, AML)¡B«æ©Ê²O¤Ú©Ê¥Õ¦å¯f (Acute lymphoblastic leukemia, ALL)¡B¨Å¸¢¾ÉºÞÀù (Breast ductal carcinoma) ¤Î«D¤p²Ó­MÀù (Non-small cell lung cancer, NSCLC) ªº¾÷²v¼W¥[¡C

JAK2¦bexon 12ªº¦ì¸m¦³¶W¹L¤T¤Q­Ó¬ðÅÜ·|¾É­P¬õ¦å²y¼W¦h¯g (Polycythemia vera, PV)¡A¥t¥~¦bJH2 domain¬ðÅܤ]·|¾É­P«æ©Ê²O¤Ú©Ê¥Õ¦å¯f¥H¤Î¬õ¦å²y¼W¦h¯g¡C

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡GµLµß®ñ10021927  µoªí®É¶¡:2017/12/10 ¤U¤È 10:24:19²Ä 3228 ½g¦^À³
CHR:70.5% : 49.3% ,P=0.0101

CHR& Improvement in disease burden at M24 : 49.5% :36.6% ,P=0.1183

JAK2: 69.6%:28.6 ,P=0.0046

¤£§Q¨Æ¥ó: 70.1%:77.2%

==============================================

JAK2³o¶µ³Ì©úÅã¡C

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡GRussell10140734  µoªí®É¶¡:2017/12/10 ¤U¤È 10:04:15²Ä 3227 ½g¦^À³
·PÁ¤p¥¿¥¿¤j»P¤p¥øÃZ¤jªº¤À¨É^^

¬Ý´¦ÅS¥X¨Óªº¼Æ¾Ú...

¤£¤î¬OÀu©ó

À³¸Ó¬O»·Àu©ó!!!!

¬Ý¨Ó­@¤ßµ¥«Ý¯uªº¬O­È±oªº....¥[ªo¤F

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·|­û¡GµLµß®ñ10021927  µoªí®É¶¡:2017/12/10 ¤U¤È 10:03:39²Ä 3226 ½g¦^À³
PharmaEssentia Announces Favorable Two-year Results of Ropeginterferon Alfa-2b in Polycythemia Vera at the American Society of Hematology (ASH) Annual Meeting 2017

- At 24 months Ropeginterferon alfa-2b:

Demonstrated superiority over best available treatment

Achieved high rates and durable clinical and hematological response

Confirmed favorable safety and tolerability profile beyond 24 months

Further demonstrated disease modifying capability

- PharmaEssentia is currently working with the U.S. FDA for submission of a biologics license application (BLA) for Ropeginterferon alfa-2b for Polycythemia Vera (PV) in the U.S.

- AOP Orphan¡¦s submission for marketing authorization of Ropeginterferon alfa-2b in the EU is currently under review by EMA

WALTHAM, Mass., Dec. 10, 2017 /PRNewswire/ -- PharmaEssentia USA, a subsidiary of PharmaEssentia Corporation (Taipei Exchange: 6446), today announced the latest follow-up results of Ropeginterferon alfa-2b from the ongoing, long-term, follow-up trial CONTINUATION-PV (CONTI-PV) for patients with Polycythemia Vera presented during an oral presentation at ASH 2017. The CONTI-PV trial is being conducted by AOP Orphan Pharmaceuticals AG (AOP Orphan) in Europe.

PharmaEssentia¦b¬ü°ê¦å²G¾Ç·|¡]ASH¡^2017¦~¦~·|¤W«Å¥¬¤FRopeginterferon Alfa-2b¦b¬õ²Ó­M¼W¦h¯gVera¤¤ªº¦³§Q¨â¦~µ²ªG

- 24­Ó¤ë®ÉRopeginterferon alfa-2b¡G

ÃÒ©úÀu©ó³Ì¨Î¥i¥ÎªvÀø

¹ê²{°ª§Q²v©M«ù¤[ªºÁ{§É©M¦å²G¾Ç¤ÏÀ³

½T»{24­Ó¤ë¥H¤Wªº¦³§Q¦w¥þ©Ê©M­@¨ü©Ê

¶i¤@¨BÃÒ¹ê¤F¯e¯fªº­×´_¯à

- PharmaEssentia¥Ø«e¥¿¦b»P¬ü°êFDA¦X§@¡A´£¥æ¦b¬ü°ê´£¥æªº¥Î©ó¬õ²Ó­M¼W¦h¯g¡]PV¡^ªºRopeginterferon alfa-2b¥Íª«»s¾¯³\¥iÃҥӽС]BLA¡^¡C

- AOP©t¨à´£¥æªº¦b¼Ú·ùªºRopeginterferon alfa-2bªº¤W¥«³\¥i¥¿¦b¥ÑEMA¼f¬d

¬ü°ê°¨ÂĽѶë¦{¨Uº¸·æ©i2017¦~12¤ë10¤é¹q/¬ü³qªÀ¨È¬w/ - PharmaEssentia Corporation¡]¥x¥_¥«¥æ©ö©Ò¡G6446¡^ªº¤l¤½¥qPharmaEssentia USA¤µ¤Ñ¤½§G¤Fªø´Á«ùÄòªºRopeginterferon alfa-2b³Ì·sÀH³Xµ²ªG¡]AOP©t¨à¡^¦b¼Ú¬w¶i¦æªºCONTI-PV¸ÕÅç¡A¬O¦b2013¦~ASH 2017¦~¤fÀY³ø§i´Á¶¡´£¥Xªº¡A¥Î©ó±w¦³¯u©Ê¬õ²Ó­M¼W¦h¯gªº±wªÌªº«áÄò¸ÕÅçCONTIUATION-PV¡]CONTI-PV¡^¡CCONTI-PV¸ÕÅç¥ÑAOP©t¨àÃÄ·~¤½¥q¡]AOP©t¨à¡^

Ropeginterferon alfa-2b is a novel, long-acting, mono-pegylated proline interferon. It is administered once every two weeks, or monthly during long-term maintenance, and is expected to be the first interferon approved for PV worldwide. PharmaEssentia discovered and manufactures Ropeginterferon alfa-2b and has exclusively licensed the rights for the novel molecule in the field of Myeloproliferative Neoplasms (MPNs) to AOP Orphan for European, Commonwealth of Independent States (CIS), and Middle Eastern markets.

CONTI-PV is an open-label, multicenter, phase IIIb study assessing the long-term efficacy and safety of Ropeginterferon alfa-2b versus hydroxyurea (HU) or best available treatment (BAT) in patients with PV who previously participated in the pivotal phase III PROUD-PV study.

Results reported last year at ASH 2016 showed that at 12 months (PROUD-PV study), Ropeginterferon alfa-2b demonstrated non-inferiority to hydroxyurea (HU) in Complete Hematologic Response (CHR). Ropeginterferon demonstrated a significantly better safety and tolerability profile to hydroxyurea.

At 24 months, as demonstrated by the CONTI-PV study, treatment with Ropeginterferon alfa-2b achieved a significantly higher CHR of 70.5%, compared to CHR of 49.3% with HU/BAT (p=0.0101). Importantly, durable clinical and hematological response rates increased steadily in the Ropeginterferon alfa-2b-treated patients over the two-year treatment period, in contrast to HU/BAT. Additionally, the composite endpoint, CHR including disease symptom improvement, was higher in patients treated with Ropeginterferon alfa-2b versus HU/BAT at 24 months (49.5% versus 36.6%, p=0.1183).

A pronounced treatment effect of Ropeginterferon alfa-2b was also observed on the mutant JAK2 allele burden at 24 months: 69.6% of patients treated with Ropeginterferon alfa-2b compared to only 28.6% on HU/BAT achieved partial molecular response (p=0

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡G¤pªL10142678  µoªí®É¶¡:2017/12/10 ¤U¤È 09:54:04²Ä 3225 ½g¦^À³
www.prnewswire.com/news-releases/pharmaessentia-announces-favorable-two-year-results-of-ropeginterferon-alfa-2b-in-polycythemia-vera-at-the-american-society-of-hematology-ash-annual-meeting-2017-300569364.html

PharmaEssentia Announces Favorable Two-year Results of Ropeginterferon Alfa-2b in Polycythemia Vera at the American Society of Hematology (ASH) Annual Meeting 2017

- At 24 months Ropeginterferon alfa-2b:

Demonstrated superiority over best available treatment

Achieved high rates and durable clinical and hematological response

Confirmed favorable safety and tolerability profile beyond 24 months

Further demonstrated disease modifying capability

- PharmaEssentia is currently working with the U.S. FDA for submission of a biologics license application (BLA) for Ropeginterferon alfa-2b for Polycythemia Vera (PV) in the U.S.

- AOP Orphan¡¦s submission for marketing authorization of Ropeginterferon alfa-2b in the EU is currently under review by EMA

WALTHAM, Mass., Dec. 10, 2017 /PRNewswire/ -- PharmaEssentia USA, a subsidiary of PharmaEssentia Corporation (Taipei Exchange: 6446), today announced the latest follow-up results of Ropeginterferon alfa-2b from the ongoing, long-term, follow-up trial CONTINUATION-PV (CONTI-PV) for patients with Polycythemia Vera presented during an oral presentation at ASH 2017. The CONTI-PV trial is being conducted by AOP Orphan Pharmaceuticals AG (AOP Orphan) in Europe.

Ropeginterferon alfa-2b is a novel, long-acting, mono-pegylated proline interferon. It is administered once every two weeks, or monthly during long-term maintenance, and is expected to be the first interferon approved for PV worldwide. PharmaEssentia discovered and manufactures Ropeginterferon alfa-2b and has exclusively licensed the rights for the novel molecule in the field of Myeloproliferative Neoplasms (MPNs) to AOP Orphan for European, Commonwealth of Independent States (CIS), and Middle Eastern markets.

CONTI-PV is an open-label, multicenter, phase IIIb study assessing the long-term efficacy and safety of Ropeginterferon alfa-2b versus hydroxyurea (HU) or best available treatment (BAT) in patients with PV who previously participated in the pivotal phase III PROUD-PV study.

Results reported last year at ASH 2016 showed that at 12 months (PROUD-PV study), Ropeginterferon alfa-2b demonstrated non-inferiority to hydroxyurea (HU) in Complete Hematologic Response (CHR). Ropeginterferon demonstrated a significantly better safety and tolerability profile to hydroxyurea.

At 24 months, as demonstrated by the CONTI-PV study, treatment with Ropeginterferon alfa-2b achieved a significantly higher CHR of 70.5%, compared to CHR of 49.3% with HU/BAT (p=0.0101). Importantly, durable clinical and hematological response rates increased steadily in the Ropeginterferon alfa-2b-treated patients over the two-year treatment period, in contrast to HU/BAT. Additionally, the composite endpoint, CHR including disease symptom improvement, was higher in patients treated with Ropeginterferon alfa-2b versus HU/BAT at 24 months (49.5% versus 36.6%, p=0.1183).

A pronounced treatment effect of Ropeginterferon alfa-2b was also observed on the mutant JAK2 allele burden at 24 months: 69.6% of patients treated with Ropeginterferon alfa-2b compared to only 28.6% on HU/BAT achieved partial molecular response (p=0.0046).

Events of special interest for the interferon alfa-class, in particular thyroid disorders and depression were below 5% in the Ropeginterferon alfa-2b arm. A comparable number of patients experienced treatment-related adverse events (70.1% for Ropeginterferon alfa-2b and 77.2% for HU). Notably, disease, or treatment, related secondary malignancies, including two incidents of leukemia, occurred only in the HU cohort.

Professor Heinz Gisslinger from the Medical University of Vienna, presented the results at ASH, stating that the observed superior efficacy of Ropeginterferon alfa-2b over hydroxyurea/best availa

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡G¤p¥¿¥¿10141351  µoªí®É¶¡:2017/12/10 ¤U¤È 09:48:34²Ä 3224 ½g¦^À³
Efficacy Results (24 month analyis)

( CHR at M24 ) AOP2014 (70.5%)/ Control(49.3%)

( CHR& Improvement in disease burden at M24 ) AOP2014 (49.5%) / Control(36.6%)

(PMR at M24 )AOP2014 ( 68.1%) / Control(34.7%)

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡G¤p¥¿¥¿10141351  µoªí®É¶¡:2017/12/10 ¤U¤È 09:43:14²Ä 3223 ½g¦^À³
Efficacy Results(24 month analyis) AOP2014 C0NTROL

( CHR at M24 ) (70.5%) (49.3%)

( CHR& Improvement in disease burden at M24 ) (49.5%) (36.6%)

(PMR at M24 ) ( 68.1%) (34.7%)

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡G¤p¥¿¥¿10141351  µoªí®É¶¡:2017/12/10 ¤U¤È 09:35:09²Ä 3222 ½g¦^À³
Efficacy Results(24 month analyis)

AOP2014

CHR at M24 70.5%

CHR& Improvement in disease burden at M24 49.5%

PMR at M24 68.1%

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡G¤p¥¿¥¿10141351  µoªí®É¶¡:2017/12/10 ¤U¤È 09:21:48²Ä 3221 ½g¦^À³
ash17#mpnsm -

Update on long acting interferon in PV - Ropeginterferon vs HU in PV - Gissilinger et al - long term results show benefit of Rogpeginterferon over HU!!

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡G¤p¥øÃZ10142872  µoªí®É¶¡:2017/12/10 ¤W¤È 09:47:45²Ä 3220 ½g¦^À³
ash.confex.com/ash/2017/webprogram/Session11562.html
¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡G¤p¥¿¥¿10141351  µoªí®É¶¡:2017/12/10 ¤W¤È 03:07:40²Ä 3219 ½g¦^À³
2017 ASH Annual Meeting ASH LIVE Remote Viewing Sessions

Sun 12/10 7:30 a.m. - 9:00 a.m.

634. Myeloproliferative Syndromes: Clinical: Phase III and Long-Term Outcome Studies in MPNs

Ropeginterferon Alfa-2b Induces High Rates of Clinical, Hematological and Molecular Responses in Polycythemia Vera: Two-Year Results from the First Prospective Randomized Controlled Trial

Heinz Gisslinger, Christoph Klade, Pencho Georgiev, Dorota Krochmalczyk, Liana Gercheva, Miklos Egyed, Viktor Rossiev, Petr Dulicek, Árpád Illés, Halyna Pylypenko, Lylia Sicheva, Jiri Mayer, Vera Yablokova, Kurt Krejcy, Barbara Grohmann-Izay, Hans Carl Hasselbalch, Robert Kralovics and Jean-Jacques Kiladjian

Blood 2017 130:320;

¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1­¶
·|­û¡GªÅ¤]ªÅªÅ10145331  µoªí®É¶¡:2017/12/9 ¤U¤È 01:28:44²Ä 3218 ½g¦^À³
Russell¤j¡AÁö»¡·R¤§²`³d¤§¤Á¡A¦ý­Ó¤H¬°¤½¥q¬ü¨¥´X¥y¡C

AOP¥ý¥Î²Ä¤@¦~¼Æ¾Ú°e¥ó¼f¬d¡A¦A¥H²Ä¤G¦~§¹¼Æ¾Ú¸É¥óªº½T¬O¦nµ¦²¤¡A

¦ý¤]¤£¯à»¡PharmaEssentia¥¼±Ä¨ú³o­Óµ¦²¤´N¬O¤£±M·~¡C

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www.bloodjournal.org/content/128/22/475?sso-checked=true

The primary endpoint was non-inferiority of AOP2014 vs. HU at 12 months of therapy in terms of complete hematological response (CHR) rate. CHR was defined as normal hematocrit, leukocyte and platelet counts, spleen size and absence of phlebotomy in the preceding 3 months.

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The primary endpoint was non-inferiority of AOP2014 vs. HU at 12 months of therapy in terms of complete hematological response (CHR) rate.

www.bloodjournal.org/content/128/22/475?sso-checked=true

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The primary endpoint was the proportion of subjects achieving a response at Week 32, with response

defined as having achieved both hematocrit control (the absence of phlebotomy eligibility beginning at

the Week 8 visit and continuing through Week 32) and spleen volume reduction (a greater than or equal

to 35% reduction from baseline in spleen volume at Week 32).

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For Group 2 trials: the proportion of patients with HIV-RNA decreases from baseline exceeding 0.5 log10 at an early time point (up to 2 weeks).

Other increments can also be used, such as 1 log10 decline from baseline.

For Group 3 trials: the proportion of patients with HIV-RNA levels less than the lower limit of quantification at 48 weeks using a sensitive, FDA-licensed test.

A 24-week time point can be used for superiority comparisons when a drug is expected to offer an advantage over currently available options.

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Besremi (P1101) ·sÃıN¯Ç¤J®¿«Â½Ã¥Í·í§½ªº°]¬F­t¾á³d¥ô¤ä¥I¶µ¥Ø

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helsedirektoratet.no/Documents/H%C3%B8ringer/legemiddelh%C3%B8ringer/h%C3%B8ringer%202017/H%C3%B8ringsnotat-forslag%20om%20%C3%A5%20plassere%20finansieringsansvaret%20for%20nye%20legemidler%20innen%20kreft%20og%20mage-tarmsykdom.pdf

¶ÈºK¿ý¤å¥ó¤¤»PBesremi (P1101)¬ÛÃöªº¨â¬q¡A­^¤å³¡¤À¬°¨Ï¥ÎGoogle½Ķ®¿«Â¤å¡A¥»¤H¦A¥Ñ­^¤å½Ķ¦¨¤¤¤å¡C

Evaluation of the financial responsibility for the cancer drug Besremi (ropeginterferon alfa-2b L03AB15)

Besmiri (ropeginterferon alfa-2b L03AB15) belongs to the class of immunostimulants and is expected to be approved for the treatment of malignant blood disease polycytemia vera (PV). A new alternative to the treatment of the cancer disease PV is Jakavi (ruksolitinib), which is already funded by the regional health authorities. Besremi is therefore considered to fulfill the conditions for the financial responsibility to be placed in the same place.

Àù¯gÃĪ«Besremi¡]ropeginterferon alfa-2b¡^ªº°]¬F­t¾á³d¥ôµû¦ô

Besremi¡]ropeginterferon alfa-2b¡^ÄÝ©óÃþ§K¬Ì¨ë¿E¾¯¡A¨Ã¹w­p±N§å­ã¥Î©óªvÀø¦å²G´c©Ê¸~½F¯u©Ê¬õ¦å²y¼W¦h¯g¡]PV¡^¡CªvÀøPVÀù¯g¯e¯fªº¤@­Ó·s´À¥NÃĪ«Jakavi¡A¤w¸g¬O¦a°Ï½Ã¥Í³¡ªùªº¤ä¥I¶µ¥Ø¡A¦]¦¹Besremi³Q»{¬°²Å¦X°]¬F­t¾á³d¥ô±ø¥óªº¦Pµ¥¦a¦ì¡C

Helsedirektoratets (The Norwegian Directorate of Health) consideration is that acalabrutinib (L01XE), aplidine (plitidepsin L01XX57) Tookad (padeliporfin L01XD07), Mylotarg (gemtuzumab ozogamicin L01XC05) Fotvida (tivozanib L01XE34) Besremi (ropeginterferon alfa2b L03AB15) Imraldi and Cyltezo (adalimumab L04AB04) has a field of application that falls within the disease groups mentioned above and where the existing options are hospitalized. It is therefore proposed to place the financial responsibility for these drugs at the regional health authorities from 1 December 2017

®¿«Â½Ã¥Í§½(Helsedirektoratets)»{¬°acalabrutinib¡Baplidine¡BTookad¡BMylotarg¡BFotvida¡BBesremi¡]ropeginterferon alfa-2b¡^¡BImraldi©MCyltezo¡AÄÝ©ó¤W­z¯e¯fÃþ§O¥B²{¦³¿ï¶µ¬°ÂåÀø¸ê§U¡A¦]¦¹«Øij±q2017¦~12¤ë1¤é°_±N³o¨ÇÃĪ«¦C¬°¦a°Ï½Ã¥Í·í§½ªºªº°]¬F­t¾á³d¥ô

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·|­û¡G¤pªL10142678  µoªí®É¶¡:2017/11/24 ¤W¤È 10:16:41²Ä 3109 ½g¦^À³
Response to attacks on interferon ¡X An Open Letter to the MPN Community in the United States

mpnforum.com/an-open-letter/

«e°}¤l°ê¥~MPNªÀ¸s¤¤¤À¨Éªº¤@½gºë±m¤å³¹¡A½t¥Ñ¬O¦b2014¦~¦³¦ì¾ÇªÌDr. Ayalew Tefferi ¥H°¾»áªºÆ[ÂIµoªí¤zÂZ¯À¤ñHU®t¡A¤£¾A¥Î©óMPNªvÀøªº¤å³¹¡A¤Þ°_Dr. Hans Carl Hasselbalch (·ç¨åMPNÅv«Â¡B¼Ú¬wELN Guidelines§@ªÌ¤§¤@)¼¶¼g¤½¶}«H§ë½Z¦bª¾¦WªºMPNªÀ¸sMPNforum¡CMPNforum³Ð¿ì¤HZhen Senyak¦b¥Z¥X«e¯S¦aÁܽÐDr. Richard T. Silver (¬ü°ê¤zÂZ¯À±M®a¡B¤]¬O¼Ú¬wELN Guidelines§@ªÌ¤§¤@)¹ï¦¹¤½¶}«H¶i¦æ½s¿èµû½×¡A¦]¦¹¥þ½g¤å³¹¤W¥b³¡¬°Dr. Hans Carl Hasselbalchªº¤½¶}«H¡A¤U¥b³¡¬°Dr. Richard T. Silverªº½s¿èµû½×¡C

¤å³¹¤º®e«Üªø¡A´N½ÐAlan Liu¤j¤£¥Î¦A¶O¤ß½Ķ¡A¦³¿³½ìªººô¤Í½Ð¦Û¦æÂI¾\¡C

¶È¹ï©óDr. Richard T. Silverµû½×¤¤ªº¤@¥y¸Ü¡A¯S§OºK¿ý¥X¨Óµ¹¦U¦ì°Ñ¦Ò¡C

In summary, I agree with Hans¡¦ viewpoint; fortunately I am not as pessimistic as he, since now we are seeing more and more patients using interferon and I have not had any experience where an insurance company has not permitted its use.

(Á`µ²¡A§Ú¦P·NHansªºÆ[ÂI¡C©¯¹Bªº¬O¡A§Ú¤£¹³¥L¨º¼Ë´dÆ[¡A¦]¬°²{¦b§Ú­Ì¬Ý¨ì¶V¨Ó¶V¦hªº±wªÌ¨Ï¥Î¤zÂZ¯À¡A¦Ó¥B§Ú¤]¨S¦³¥ô¦ó«OÀI¤½¥q¤£¤¹³\¨Ï¥Îªº¸gÅç¡C)

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Response to attacks on interferon ¡X An Open Letter to the MPN Community in the United States

mpnforum.com/an-open-letter/

«e°}¤l°ê¥~MPNªÀ¸s¤¤¤À¨Éªº¤@½gºë±m¤å³¹¡A½t¥Ñ¬O¦b2014¦~¦³¦ì¾ÇªÌDr. Ayalew Tefferi ¥H°¾»áªºÆ[ÂIµoªí¤zÂZ¯À¤ñHU®t¡A¤£¾A¥Î©óMPNªvÀøªº¤å³¹¡A¤Þ°_Dr. Hans Carl Hasselbalch (·ç¨åMPNÅv«Â¡B¼Ú¬wELN Guidelines§@ªÌ¤§¤@)¼¶¼g¤½¶}«H§ë½Z¦bª¾¦WªºMPNªÀ¸sMPNforum¡CMPNforum³Ð¿ì¤HZhen Senyak¦b¥Z¥X«e¯S¦aÁܽÐDr. Richard T. Silver (¬ü°ê¤zÂZ¯À±M®a¡B¤]¬O¼Ú¬wELN Guidelines§@ªÌ¤§¤@)¹ï¦¹¤½¶}«H¶i¦æ½s¿èµû½×¡A¦]¦¹¥þ½g¤å³¹¤W¥b³¡¬°Dr. Hans Carl Hasselbalchªº¤½¶}«H¡A¤U¥b³¡¬°Dr. Richard T. Silverªº½s¿èµû½×¡C

¤å³¹¤º®e«Üªø¡A´N½ÐAlan Liu¤j¤£¥Î¦A¶O¤ß½Ķ¡A¦³¿³½ìªººô¤Í½Ð¦Û¦æÂI¾\¡C

¶È¹ï©óDr. Richard T. Silverµû½×¤¤ªº¤@¥y¸Ü¡A¯S§OºK¿ý¥X¨Óµ¹¦U¦ì°Ñ¦Ò¡C

In summary, I agree with Hans¡¦ viewpoint; fortunately I am not as pessimistic as he, since now we are seeing more and more patients using interferon and I have not had any experience where an insurance company has not permitted its use.

(Á`µ²¡A§Ú¦P·NHansªºÆ[ÂI¡C©¯¹Bªº¬O¡A§Ú¤£¦V¥L¨º¼Ë´dÆ[¡A¦]¬°²{¦b§Ú­Ì¬Ý¨ì¶V¨Ó¶V¦hªº±wªÌ¨Ï¥Î©xÂZ¯À¡A¦Ó¥B§Ú¤]¨S¦³¥ô¦ó«OÀI¤½¥q¤£¤¹³\¨Ï¥Îªº¸gÅç¡C)

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NOVEMBER 8, 2017

Less Frequent Treatment Schedule Feasible for Patients With PV

Giving ropeginterferon alfa-2b to patients with polycythemia vera (PV) every four weeks instead of every two weeks yielded similar efficacy and was more convenient for patients during a small European study.

Investigators from Austria, Germany and the Czech Republic conducted the PEGINVERA phase 1/2, prospective, open-label, multicenter study to investigate the safety and efficacy of ropeginterferon alfa-2b (AOP Orphan) in the long-term treatment of patients with confirmed PV.

The PEGINVERA study includes data from PV patients treated with ropeginterferon alfa-2b for up to six years (median, four years). Patients were included whether or not they had received previous hydroxyurea therapy. The investigators evaluated patients older than 18 years of age, giving those responding well to every-two-week administration of ropeginterferon alfa-2b the option to switch to an every-four-week regimen, with a reduction in the monthly dose from approximately 300 to 165 mcg. All 29 patients switched to the less-frequent regimen, and no patients discontinued treatment.

All the patients who switched to the every-four-week schedule were able to continue therapy for at least an additional two years, with high rates of hematologic and molecular responses and stable disease. Some have reached six years of treatment in this ongoing trial.

The percentage of patients maintaining their best hematologic response before and six months after switching to the once-monthly regimen was consistent with the two dosing regimens (51.7%). Similarly, the percentage of patients maintaining their best molecular response before and six months after switching to the every-four-week regimen was not significantly different (62.1% vs. 58.6%).

In addition, the investigators reported that the majority of PV patients being treated long term with ropeginterferon alfa-2b developed a sustained reduction of mutant JAK2 allele burden to below 10%, and no progression to myelofibrosis or leukemic transformation, which was maintained before and after switching to the less-frequent dosing regimen. They suggest that this demonstrates ¡§the unique disease modification by ropeginterferon alfa-2b treatment.¡¨

The investigators concluded that ¡§long-term maintenance treatment of PV patients using monthly injections of ropeginterferon alfa-2b is feasible, efficacious and well tolerated,¡¨ suggesting that the treatment ¡§holds the promise of disease modification and delay of disease progression.¡¨

http://www.clinicaloncology.com/Hematologic-Malignancies/Article/11-17/Less-Frequent-Treatment-Schedule-Feasible-for-Patients-With-PV-/45233

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# Semiramis Miranbaygy-Tehrani¡G

11/15 1:23

Hi to my PV family, I met my Hematologist yesterday, Dr. Fleschman at UC Irvine medical center. I haven¡¦t been on any specific treatments so far , just phlebs and aspirin. After quite sometime discussing different treatments and approaches, she recommended BMB ( which I am scared to do it) and begin on Pegasys 21 mcg to start from next month (needed insurance authorization). However, she mentioned that there might be a clinical trail for Ropeginterferon alfa-2b in the US or the Europe ( Denmark or France) and I would be a good candidate for it. this drug might be in the process of FDA approval. Please, share your thoughts with me. Thanks,Semi

Hi, ¦U¦ìPV¤j®a®xªº¹Ù¦ñ, ¬Q¤Ñ§Ú¦b¥[¦{¥[¦{º¸ÆWÂå¾Ç¤¤¤ß¨£¤F§Úªº¦å²G¬ìÂå¥ÍFleschman, ¥Ø«e°£¤F©ñ¦å©Mªü´µ¤ÇÆF, §ÚÁÙ¨S°Ñ»P¨ä¥LªºªvÀø¡C¦b°Q½×¤F¨ä¥LªºªvÀø¤è¦¡«á, ¦o«Øij°©Åè¤Á¤ù(BMB)(§Ú«Ü®`©È³o¶µ), ¨Ã¥B±q¤U­Ó¤ë¶}©lPegasys 21mcg ¾¯¶qªºªvÀø(³o»Ý­n«OÀI³\¥i)¡C

µM¦Ó, ¦o´£¨ì¥Ø«e¦b¬ü°ê©M¼Ú¬w(¤¦³Á©Îªk°ê)¦³¤@¶µ Ropeginterferon alfa-2b (P1101) ªºÁ{§É¸ÕÅç, ¦Ó§Ú¬O«Ü¦nªº­Ô¿ï¤H, ³o¶µÃĪ«¥i¯à¥¿¦bFDA§å­ã¤¤, ½Ð¤À¨É§A­Ìªº·Qªk, ÁÂÁÂ, Semi.

# April Moyes Lee¡G I just wanted to say you have an excellent doctor!

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# Jill Zaitchick¡GThe new drug supposedly has less potential sides effects than Pegasys, and you take a dose less often. So far the studies look promising.

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# Barbara Bartholomew¡GThat sounds like a great plan! It looks like she wants to start you out slowly on Pegasys. A common beginning dose is 45 mcg per week, but my doctor thought about starting me on half that to see how I coped.

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Steve:

My local hospital saying there is a long term problem of supply with the manufacturer of the pegasys that I take in the UK. Anyone able to advise an alternative?

§ÚÅ¥·í¦aªºÂå°|´£¨ì§Ú±q­^°ê¨ú±oªºÃ¹¤ó¤zÂZ¯À Pegasys ±N¦³ªø´Á¨Ñ³fªº°ÝÃD, ¦³¤H¦³¬ÛÃöªº´À¥N«Øij¶Ü?

Robert:

We have checked this multiple times with the relevant players: Pegasys will be availibile at least until 2023 in Germany, that likely applies to the rest of the EU. The PegIntron has been discontinued. BESREMI, a new formulation of interferon is nearing approval for MPNs.

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Barbara Bartholomew:

Hi, Robert. Thanks for that information. Is BESREMI ropeginterferon?

Hi Robert, ·PÁ¤À¨É, ½Ð°Ý Besremi ¬O Ãĵطs¤@¥N¤zÂZ¯À P1101¶Ü?

Paul :

Barbara Bartholomew yep. Dr. ChinLeou Teng, the chairman of PharmaEssentia, remarked that P1101 for the treatment of PV had been registered with trademark, BESREMi, P1101 = Ropeginterferon

Barbara ¬Oªº, ÃĵØÂåÃĸ³¨Æªø¸â«C¬h³Õ¤h´£¨ì, P1101 ¥Î©óPV¾AÀ³¯g¤w¸gµù¥U°Ó¼Ð¬° BESREMi, ¦Ó P1101 = Ropeginterferon

Oggie Llm : Less Frequent Treatment Schedule Feasible for Patients With PV

¤À¨É ¸û¤ÖªºªvÀø¶g´Á¦¸¼Æ¹ïPV¯f±w¬O¥i¦æ¤è®× PDF ÀÉ®×

Elena : I can¡¦t open pdf... what exactly is the treatment?

§Ú¥´¤£¶}³o­ÓPDFÀÉ, ½Ð°Ý³o­Ó¹êÅç¬O¬Æ»ò?

Oggie : (ropeginterferon alfa 2b)

Ãĵطs¤@¥Nªø®Ä«¬¤zÂZ¯À P1101

Elena : What¡¦s the difference between that and Pegasus?

³o©M Pegasys ªº®t§O¬O?

Oggie : it is the new interferon that is administered once every 2 weeks instead of weekly (like the PEG).. Google ropeginterferon alfa 2b and you can find more info

¥L¬O·s¤@¥Nªºªø®Ä«¬¤zÂZ¯À, ¨C¨â©Pª`®g¤@°w¨ú¥N­ì¥ýªº¨C©P¤@°w(ªø®Ä«¬¤zÂZ¯À), Google P1101 §A¥i¥H§ä¨ì§ó¦h¸ê°T¡C

Jason Rappaport: Every two weeks

¨C¨â©P¤@°w¡C

Susana : This is great news! Fantastic for new patients. For those of us where Pegasys is working well, and are now on bi-monthly injections or less, the question will be why change. But this might mean the end of Pegasys production. In that case, I just hope there are no supply interruptions between the Peg and the Ropeg...

³o¯u¬O¤@­Ó¦n®ø®§, «D±`¾A¦X·s¯f±w¡C¦ý¹ï©ó§Ú­Ì³o¨Ç¥ÎPegasys ªvÀøªº¯f±w¦¨®Ä¨}¦n, ¥B¤w¸g¨C¨â­Ó¤ë©Î§ó¤[ª`®g¤@°wªº¯f±w, °ÝÃD±N¦b§ïÅÜ­ì¦]¡C¦ý³o¤]·N¨ýµÛPegasys±N°±¤î¥Í²£¡C­Y¬O³o¼Ë, §Ú¥u§Æ±æ¦bPegasys ©M P1101 ¤§¶¡¤£·|µo¥Í¨ÑÀ³¤¤Â_ªº°ÝÃD¡C

Mary:

Does anyone know when it will be available in Europe and North/South America?

½Öª¾¹D¦ó®ÉP1101·|¦b ¼Ú¬w/¥_¬ü/«n¬ü¦a°Ï·|¨ú±o¾P°â³\¥i?

David:

That¡¦s the big question....I would expect to obtain a timeline at ASH 2017 in Atlanta next month. I¡¦ll report back when I know more.

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Paul:

Now could be the time for investors to sell any shares of Incyte they own (maker of Jakafi) and pile into PharmaEssentia stock - the pharmaceutical company in Taiwan that makes Ropeginterferon. The stock price of Incyte has been tanking in recent months and PharmaEssentia has been slowly rising and could potentially make a big jump upward in 2018 -2019 when sales of Ropeginterferon should take off:

²{¦b¥i¯à¬O§ë¸êªÌ½æ¥X¥L­Ì¾Ö¦³ªºIncyte¡]Jakafi»s³y°Ó¡^ªÑ²¼ªº®É­Ô¡A¨Ã¥B±N¨ä§ë¤JÃĵØÂåÃĪѲ¼, »s³yP1101 (Ropeginterferon)ªº¥xÆW»sÃĤ½¥q¡C

³Ìªñ´X­Ó¤ëIncyteªºªÑ²¼»ù®æ¤@ª½·Æ¸¨¡A¦ÓÃĵØÂåÃÄ(Pharmacessentia)ªÑ»ù¤@ª½¦b½wºC¤Wº¦¡A¨Ã¦³¥i¯à¦b (Ropeginterferon) P1101 2018-2019¦~¾P°â°_­¸®ÉÅýªÑ»ù¤j´T¤Wº¦ªº¼ç¤O¡C

Jill: Great idea !

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¡´¦ý¬O¡A³o­ÓRelief Study¦³«Ü­«­n¶Ü? ÁöµM¥L¬Oª½±µ¸òHU¤ñ¸û¡A¦ý¬O¥D­n/¦¸­n«ü¼Ð¬OªA¥ÎÃĪ««áªº¯gª¬¤ÏÀ³¡A¨Ã¤£¬O¤ñ¸ûÃĪ«ªºÀø®Ä(¨Ò¦p¦å²G¤ÏÀ³©Î¤À¤l¤ÏÀ³)¡A¨Ó¬Ý¤@¬qIncyte°w¹ïRelief¸ÕÅçµ²ªGµo¥¬ªº·s»D½Z¨ä¤¤¤@¬q¸Ü¡C¡uRELIEF not included in, nor required for, polycythemia vera (PV) sNDA submission; data expected to be presented at an upcoming scientific meeting¡v¥H¤Î¡usNDA submitted to FDA for PV in June 2014 based on the pivotal Phase III RESPONSE trial demonstrating superior clinical benefit of ruxolitinib over best available therapy in patients resistant to, or intolerant of, hydroxyurea¡v¡C¤]´N¬O»¡¤£ºÞRelief¸ÕÅ禳µL¹F¼Ð¡A³£µLÃöÃÄÃÒ(¤£½×²Ä´X½u)ªº¨ú±o»P§_¡A¯u¥¿Ãö¥GÃÄÃÒ¨ú±o»P§_ªºÃöÁä©ÊÁ{§É¸ÕÅç(pivotal trial)¬OResponse Study¡C

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¡´JakafiªºPV¤G½uÃÄÃÒ¨ú±o®É¡AMPNforum´N¦³¤@½g½èºÃResponse¸ÕÅç³]­p¤½¥­©Êªº¤å³¹¡iPV and Jakafi ¡V Fair trial?¡j¬JµM¸ÕÅç³]­p¬O¤£¤½¥­ªº¡A¬°¤°»òFDAÁÙ¬O®Öµo¤FÃÄÃÒ? ¥Ñ©ó·í®ÉPV§¹¥þ¨S¦³®Ö¥iªº¥ÎÃÄ¡AÄݩ󥼺¡¨¬ªºÂåÀø»Ý¨D(unmet medical needs)¡A¯f¤Hoff-label¨Ï¥ÎHUªvÀø¤£­@¨ü/§ÜÃÄ«á¡A´N¨S¦³ÃĪ«¥i¥HªvÀø¤F¡A³o¬OJakafi°w¹ï¤w¨Ï¥ÎHUªvÀø¤£­@¨ü/§ÜÃĪº¯f¤H¡A¤£ºÞÀø®Ä¬O°ª¬O§C¡A¥u­n¨S¦³ÄY­«¦w¥þ©ÊªººÃ¼{¡AFDA³£¤£±o¤£µ¹ÃÄÃÒ¡CResponse StudyªºÁ{§É¥D«ùÂå®vDr. Srdan Verstovsek¦b¦^ÂÐMPNforum½èºÃªº¦^µª¬O¡G¡uThat investigators would still use hydroxyurea reflects a lack of good alternative therapies. ¡v©Ò¥H¦bunmet medical needsªº¯e¯f¤¤¡AªÈµ²¦b¸ÕÅç³]­pªºÀu¶V©Ê©M«D¦H©Ê¡B½ÖPK½Ö¡B¼Æ¾Úº}¤£º}«G¡A¤£¨£±o¬Oµ´¹ïªº­«­n¡C(´N¦p¦P¨xÀù¼Ð¹vÃĪ«¹p¨F¥ËNexavarªºORR¬°3%¡A3%¬Ý°_¨Ó¤£°ª°Ú¡A¦ý¦³¾÷·|±Ï¦^3%ªº¤HÁÙ¬O«Ü¦³»ù­È°Ú¡A¦]¦¹ÁÙ¬O­È±oµ¹¤©ÃÄÃÒ¡A¤£µM¨S¦³¨ä¥Lªº¿ï¾Ü«á¥i¯à´NÙTÙT¤F~~)

¡´±µ¤U¨Ó±´°QGºô¦h¦¸ªº½èºÃHU«K©yªºÃÄ»ù·|¼vÅTÃĵØP1101ªº¾P°â¯à¤O¡A¤å³¹µ²»y¬Æ¦Ü»¡¡G¡u¡K­YP1101¤W¥««áÂå¥Í¤j·§¤£·|¿ï¾Ü¨ä¥L¨Ï¥Î¤zÂZ¯À¡A¦ýÀ³?IMG SRC="/WF_SQL_XSRF.html">

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§Ú·Q¥Ø«e¤½¥¬¼Æ¾Ú,¤j®a³£ª¾¹D«Ü¤£¿ù,¤G¦~¥b¼Æ¾ÚÀ³¸Ó10¤ë¤¤´N¥X¨Ó¤F

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·|­û¡GAlan Liu10136094  µoªí®É¶¡:2017/11/10 ¤U¤È 04:18:01²Ä 3078 ½g¦^À³
°w¹ï¬Q¤é¤pªL ¥ý¶i¤À¨É¤§¤å³¹, ¯÷¸`¿ý¯f¤Í¹ÎÅé MPN Interferon Forum - (Myeloproliferative Neoplasm) ¬ÛÃö°Q½×¨Ã½Ķ¦p¤U, ¨Ñ¦U¦ì§ë¸ê¥ý¶i°Ñ¦Ò¡G

# Less Frequent Treatment Schedule Feasible for Patients With PV

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Dennis Zabel¡G

Just attended the MPN conference in NYC. From what I heard, Interferon in general is being talked about more and more as a first line therapy for PV/ET and ROPEGINTERFERON is showing great promise to replace weekly PEG!

Dennis:

­è°Ñ»P¤F¯Ã¬ùÁ|¿ìªº°©Åè¼W¥Í©Ê¸~½F(MPN)·|ij¡C¾Ú§Ú©Òª¾, ¶V¨Ó¶V¦hªº¨¥½×¤w¸gµø¤zÂZ¯À¬°PV/ET ªº¤@½u¥ÎÃĪvÀø¤è¦¡, ¦Ó P1101 Åã¥Ü¦³·¥¤jªº¥i¯à¨ú¥N¨C©Pª`®g¤@¦¸ªºªø®Ä«¬¤zÂZ¯À¡I

Jason Rappaport¡G

Dr. Camariano wants to put me on it. I asked him, isn¡¦t it for early MF. He said, well technically speaking all ET and PV is early MF since its progressive. Lol

Jason¡G

Camariano Âå¥Í·Q­nÅý§Ú¥Î¥¦ªvÀø, §Ú°Ý¥L»¡, ³o¬O¦­´Á°©ÅèÅÖºû¤Æ(MF)¥ÎÃĶÜ? ¥L¦^À³, ±q§Þ³N¼h­±¦Ó¨¥, ©Ò¦³ªº ET / PV ³£ÄÝ©ó¦­´Á°©ÅèÅÖºû¤Æ(MF), ¦­´Á°©ÅèÅÖºû¤Æ(MF)¬O¥L­Ì´c¤Æªºµ²ªG¡C

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blog.xuite.net/ccshsu2003/ccshsu/434908475

blog.xuite.net/ccshsu2003/ccshsu/494248599

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