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¦³¶R¬üªÑªº¡A¥i¯d·N³o®aMadrigal¡A¦ü¥GÄøÄø±ý°Ê? ¦pªG [Madrigal]ªºPh3¤£n¥X¤j问题¡A§Ú们会¦b2023¦~¬Ý¨ì²Ä¤@个获§åªºNASH药ª«!!! --------------------------------------------------------------------------------------------- ·|û¡GROGER588910148151 µoªí®É¶¡:2021/2/21 ¤U¤È 12:54:38²Ä 807 ½g¦^À³ ¦b³Ì¦³¾÷·|¹Ü±o²Ä1¤äNASH¤W¥«ÃÄÃÒªºOcaliva¡]Intercept¡^¦]¬°[¨x¬r©Ê]°Æ§@¥Î³Q§_¨M«á¡A ±µ¤U¨Ó·~¬É»{¬°²Ä1¤äNASH¤W¥«ÃĪ«·|¬OMadrigal¤½¥qªºMGL3196¡]Resmetirom¡^¡H ¦³«GÂIªº¬OªYÄ£ªºªk»¡·|¸ê®Æ¡]²Ä19〜22¶¡^¡GSNP-610ªºP2ªì¨B¼Æ¾ÚÀu©óMGL3196¡]Resmetirom¡^¡A·íµM¦¨©Î±Ñ±o¬ÝP3³Ì²×µ²ªG¡C -------------------------------------------------------------------------------------------- ·|û¡GROGER588910148151µoªí®É¶¡¡G2020/7/3¤W¤È08:05:38²Ä35½g¦^Î` 108/07/24 Bio-Asia¨È¬w¥Í§Þ¤j®iÁ|¿ì¤§¤½¥q®i±æ»¡©ú·| mops.twse.com.tw/nas/STR/663420190724M001.pdf Phase II study: - The decreases in several clinical parameters from baseline to the end of treatment were greater in SNP-610-12-week treatment than Ocaliva, Cenicriviroc, Elafibranor, MGL3196 or Selonsertib treatment in literature, especially in ALT. --------------------------------------------------------------------------------------- 2021.2.3 FDA开讲®y«ü点NASH·s药¬ã发 mp.weixin.qq.com/s?__biz=MzI5NzY0NDQyNQ==&mid=2247597425&idx=5&sn=5603a91a3d5e1887bf2a13fdd349484d&chksm=ecb2c597dbc54c813151617dccf12977839e42fd2f0716ebdc70ba293bbf63b233b21e5a922f&scene=21#wechat_redirect ..2022¦~¦ô计会¬ONASH领°ì°_飞ªº¤@¦~¡A¦pªG [Madrigal]ªºPh3¤£n¥X¤j问题¡A§Ú们会¦b2023¦~¬Ý¨ì²Ä¤@个获§åªºNASH药ª«¡A¨ì时Ô¾ã个资¥»¥«场会¥Î«D±`¤£¦Pªº²´¥ú来¬Ý¾ã个领°ì¡C当§ó¦h资¥»¯F进来ªº时Ô¡A¨Æ±¡会变±o«D±`¦³·N«ä¡C |
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·|û¡GROGER588910148151 µoªí®É¶¡:2021/4/23 ¤U¤È 08:50:23²Ä 1059 ½g¦^À³
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®ÄªG¤ñ¸û¦n¬Oª½·o®Ö¤ßªºÃö«Y? SNP-610©ó¤HÅé¤G´ÁÁ{§É¸ÕÅçÃÒ©ú¦w¥þ¦³®Ä¡A¥BÀu©ó°ê»Ú²{¦æ¥|®a¥ýµoªºNASHÃĪ«¡C SNP-610Á{§É¦³¨º¨Ç°Æ§@¥Î??? --------------------------------------------------------------------------- ·|û¡GROGER588910148151 µoªí®É¶¡:2021/2/21 ¤U¤È 04:22:05²Ä 811 ½g¦^À³ SNP-6:P2¼Æ¾ÚÀu©ó¹w´Á·|¦b2020®Öã¤W¥«ªº Ocaliva¡]µ²§½¬O³QFDA§_¨M)! ¥çÀu©ó±µ¤U¨Ó·~¬É»{¬°2023¦~²Ä1¤ä¤W¥«ªºNASHÃĪ«: MGL3196¡]Resmetirom¡^? .... |
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·|û¡GROGER588910148151 µoªí®É¶¡:2021/4/23 ¤U¤È 08:40:48²Ä 1058 ½g¦^À³
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±q¾Ç²z¬ã¨sª½·oµo¯f¾÷¨îªº®Ö¤ß·|¦³®Ä¡A¥u¬O²³¦hÃļtªºDGAT1ÃĪ«¹L¤£¤FG¸z°Æ§@¥ÎÃö¥d¡C SNP-610ªºÁ{§É¤G´Á¦¬®×36¤H¦³¨º¨Ç°Æ§@¥Î??? ---------------------------------------------------------------------------------------- 1. 2010.2.18 www.ahajournals.org/doi/full/10.1161/atvbaha.109.201426 ¬ã¨s½T©w¤FDGAT1¬O¤@ºØ«n³J¥Õ¡A°Ñ»P¤FHNF4A¹ïTRLs¨x¤Àªcªº¼vÅT¡C 2. 2015.6.23 Nature½×¤å www.nature.com/articles/ncomms8466 «D°sºë©Ê¯×ªÕ©Ê¨x¯f¡]NAFLD¡^¬O³Ì±`¨£ªº¨x¯f¤§¤@¡A¦ý¨ä¼ç¦b¾÷¨î©|¤£²M·¡¡C¦b³o¸Ì¡A§ÚÌÅã¥Ü¨x²ÓM®Ö¦]¤l4£\¡]HNF4£\¡^...¹v¦V¸Ó³~®|¥i¯à¥Nªí¤F¤@ºØªvÀøNAFLDªº·s¤èªk¡C 3. 2017.12.7 : pubmed.ncbi.nlm.nih.gov/29216278/ ¤ÀªR½T©wHNF4A¬O«D°sºë©Ê¯×ªÕ©Ê¨xª¢µo¯f¾÷²zªº¤¤¤ß°ò¦] ¦]¦¹¡A§Ú̺¦¸¤F¸Ñ¨ì¡AHNF4A¬ONASHµo¯f¾÷¨îªº®Ö¤ß¡C |
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±µ³s¼Æ®aÃļtªºDGAT1ÃĪ«Á{§É³£¥X²{ÄY«¤£¤@ªºG¸z°Æ§@¥Î¡A©ó¬O»{¬°DGAT1¹vÂIµLªk¦¨ÃÄ¡A¯É¯ÉÂ੹¨ä¥L³~®|.... ©Ò¥HY¯à½T»{SNP-610(CYP2E1 + DGAT1, ¥´2ÓÂI)¸ó¹LG¸z°Æ§@¥ÎªùÂe»Ùê¡ASNP-610/ SNP-630¦¨¥\¾÷²v´N«Ü¤j¡C ªü´µ§Q±dAZD7687(DGAT1ÃĪ«)§ïÅܤF¸z¹D¤¤ªº¯×½è³B²z©M¿E¯À¤Àªc¡A¦ý²£¥Í¤FµLªk§Ô¨üªº°Æ§@¥Î! pubmed.ncbi.nlm.nih.gov/24118885/ µ²½×¡G¦b¥ÎDGAT1§í»s¾¯AZD7687ªvÀø1¶g´Á¶¡...¡A¥Ñ©óAZD7687¤×¨ä¬O¸¡ÂmªºG¸z¹D°Æ§@¥Î...³o¨Ï±oDGAT1§í»s§@¬°¿}§¿¯f©MªÎD¯gªº·s«¬ªvÀø¤èªkªº¹ê¥Î©ÊȱoÃhºÃ¡C ----------------------------------------------------------------------------------------------- ·|û¡GROGER588910148151 µoªí®É¶¡:2021/4/22 ¤U¤È 03:41:18²Ä 1053 ½g¦^À³ ³Ò¥hªÑªF·|ªÌ¸ß°Ý: SNP-610(CYP2E1 + DGAT1, ¥´2ÓÂI)NASHÁ{§É¤G´Á36¤H¦³¨S¦³G¸z°Æ§@¥Î??? ¦pªG¯à½T»{¸ó¹LG¸z°Æ§@¥ÎªùÂe»Ùê¡ASNP-610/ SNP-630¦¨¥\¾÷²v´N«Ü¤j¡C |
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GSK¨Ã¨S¦³©ñ±óDGAT1!(´X®a¤j¼tªºÁ{§É©ú½T¦³Àø®Ä¡A¤]³£¥X²{»P¾¯¶q©úÅã¬ÛÃöªºG¸z°Æ§@¥Î) ©³¤U¬OGSK·s¶}µoªº·s«¬DGAT1ÃĪ«GSK2973980A¡A¨ã¦³§ó¦nªºG¸z@¨ü©Ê! [with potentially better GI tolerability] 2017.9.19: file:///C:/Users/USER/Downloads/19787-Article%20Text-36724-1-10-20181214.pdf Conclusion: Our data suggest that the impaired TG clearance model in the rat can be used to identify DGAT1 inhibitors with potentially better GI tolerability. ------------------------------------------------------------------------------------------ ·|û¡GROGER588910148151 µoªí®É¶¡:2021/4/22 ¤U¤È 03:41:18²Ä 1053 ½g¦^À³ .... GSKªºGSK3008356(DGAT1§í¨î¾¯,¥´1ÓÂI)¡A¦bNASHÁ{§É¤]¬OG¸z°Æ§@¥Î(©Ô¨{¤l)¡A½æµ¹¤p¼tªvÀøÚµ½HÁ{§É¡C |
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DGAT1¤]´¿¬OªvÀøNASHªº¼öªù¹vÂI¡A¦ý¬O´X®a¤jÃļtªºÁ{§É±µ³s±Ñ¦bG¸z°Æ§@¥Î¡ADGAT1¤]³Q»{¬°¤£¯à¦¨ÃÄ¡A ©Ò¥H·Q½T»{SNP-610¬O§_¸ó¹LG¸z°Æ§@¥ÎªùÂe»Ùê??? ¦w¶iSotorasib¬D¾Ô³ÌÃøÀù°ò¦]KRAS ¡A²×©ó¬ð¯}KRAS¤£¯à¦¨ÃĪºÅ]©G! 2021.1.31·¥´¶¹MªºPÀù°ò¦] KRAS ¬ðÅÜ¡A²×©ó¦³¼Ð¹vÃĪ«¥i¹ï¥I technews.tw/2021/01/31/kras-mutation-of-the-oncogene-breakthrough-treatment-of-targeted-drugs/ ....30 ¦h¦~¨Ó¡A¬ì¾Ç®a¤@ª½¸Õ¹Ï°w¹ï KRAS ¬ðÅܬãµo§ÜÀùÃĪ«¡A¹Lµ{¤¤¸g¾úµL¼Æ¥¢±Ñ»P®À§é¡A¤@«×»{¬°¬OµLÃÄ¥iªvªºPÀù°ò¦]¡C |
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³Ò¥hªÑªF·|ªÌ¸ß°Ý: SNP-610(CYP2E1 + DGAT1, ¥´2ÓÂI)NASHÁ{§É¤G´Á36¤H¦³¨S¦³G¸z°Æ§@¥Î??? ¦pªG¯à½T»{¸ó¹LG¸z°Æ§@¥ÎªùÂe»Ùê¡ASNP-610/ SNP-630¦¨¥\¾÷²v´N«Ü¤j¡C ¦]¬°诺华ªºpradigastat(DGAT1§í¨î剂, ¥´1ÓÂI)¦bNASHÁ{§É¦³G¸z°Æ§@¥Î(©Ô¨{¤l)¡A ©Ò¥H½æµ¹¤p¼t§ï§@¥\¯à©Ê«K¯µÁ{§É¡C GSKªºGSK3008356(DGAT1§í¨î¾¯,¥´1ÓÂI)¡A¦bNASHÁ{§É¤]¬OG¸z°Æ§@¥Î(©Ô¨{¤l)¡A½æµ¹¤p¼tªvÀøÚµ½HÁ{§É¡C 2020.09.15 药«~¦W称¡GPradigastat ¤ù ¥ø业¦W称¡G¦w济药业¡]¤W®ü¡^¦³¤½¥q ¥»«~¬O¤G酰°ò¥Ìªo酰°ò转²¾酶¡]DGAT1¡^ªº¤p¤À¤l§í¨î剂¡A¦¹«e¤w¦b¥N谢¯e¯f¤W开®i¤F临§É III ´Á试验¡C2019 ¦~ªì¡A¦w济药业¥¿¦¡从诺华获±o¤F pradigastat ªº±Â权¡A¥»¦¸获§åªºÓì应¯g为¥\¯à©Ê«K¯µ¡C --------------------------------------------------------------------------------------------- ·|û¡GROGER588910148151 µoªí®É¶¡:2021/1/20 ¤W¤È 05:37:39²Ä 526 ½g¦^À³ SNP-610(CYP2E1 + DGAT1, ¥´2ÓÂI)¦b¤@´Á»P¤G´ÁÁ{§É¹êÅçÀ³¸Ó¬O¸ó¹LG¸z°Æ§@¥ÎªùÂe»Ùê¡A¦¨¥\¸ô¤W¦AÁÚªñ¤@¨B! (GSK / ¿ÕµØ/ªü´µ§Q±d/½÷·çªºDGAT1ÃĪ«¤À§O±¾¦bP1»PP2) |
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