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Therapeutic medicines against the coronavirus infection Covid-19

One group of medicines does not fight viruses directly, but instead promotes the body¡¦s own virus defence: interferons. They are variants of the body¡¦s own messenger substances that are produced genetically. Biochemists divide these messenger substances into several subgroups, of which the alpha and beta interferons are important against SARS-CoV-2:

Alpha-Interferons: In a series of studies with Covid-19 patients, medicines with the active ingredients interferon alpha-1b, interferon alpha-2b (from the Cuban company BioCubaFarma and the Cuban-Chinese company Changchun Heber Biological Technology), peg-interferon-alpha-2a (produced by Roche), peg-interferon-alpha-2b or novaferon (from the Chinese company Genova Biotech) were used alone or in addition to other medicines. In some cases, the respective alpha-interferon was administered in inhalable form. All these medicines have, at least in some countries, been approved for the treatment of certain viral infections, for example hepatitis B or C. BioCubaFarm has indicated that it can supply large quantities of its medicine worldwide.

Beta-Interferons: Medicines containing interferon beta-1a and interferon beta-1b are currently being tested in trials against Covid-19. The German company Merck is making its interferon beta-1a medicine available for a larger study by the INSERM institute in France. Neither medicine has been approved for antiviral therapy in the EU, but in laboratory tests interferon beta-1a was able to stop the multiplication of the related SARS viruses. For an inhalable form of interferon-beta-1a, the British company Synairgen has received approval for a study with Covid-19 patients.

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March 10, 2020: Coronavirus Disease 2019 (COVID-19) Update:

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20190118 219,265 9,860 22.24 132,098 60.25 71 15 15 3 38 51.08 170.50

20190111 219,257 9,811 22.35 132,104 60.25 71 15 15 4 37 50.64 175.50

20190104 219,233 9,756 22.47 131,780 60.11 71 16 13 5 37 50.53 174.50

20181228 219,233 9,624 22.78 131,876 60.15 72 17 13 5 37 50.38 174.50

20181222 219,227 9,578 22.89 131,767 60.11 72 17 13 5 37 50.36 177.00

20181214 219,217 9,303 23.56 131,478 59.98 71 15 14 5 37 50.39 187.50

20181207 219,217 9,295 23.58 131,504 59.99 71 15 14 5 37 50.37 184.00

20181130 219,417 9,389 23.37 131,090 59.74 70 14 14 5 37 50.40 181.50

20181123 219,411 9,439 23.25 131,158 59.78 70 14 14 5 37 50.41 174.00

20181116 219,411 9,471 23.17 131,708 60.03 71 15 13 6 37 50.44 180.50

20181109 219,377 9,531 23.02 132,181 60.25 71 15 13 6 37 50.67 172.00

20181102 219,377 9,580 22.90 131,838 60.10 71 15 14 5 37 50.63 170.50

20181026 219,367 9,568 22.93 131,821 60.09 70 16 12 5 37 50.96 164.00

20181019 219,299 9,634 22.76 132,057 60.22 71 17 12 5 37 50.95 171.00

20181012 219,292 9,506 23.07 132,238 60.30 70 17 12 5 36 50.93 162.00

20181005 219,292 9,609 22.82 131,911 60.15 69 17 11 4 37 51.33 176.00

20180928 219,292 9,676 22.66 131,151 59.81 67 15 11 4 37 51.35 179.00

20180921 219,285 9,621 22.79 130,948 59.72 66 14 10 4 38 51.88 184.50

20180914 219,274 9,658 22.70 130,953 59.72 66 14 11 4 37 51.54 176.00

20180907 219,270 9,732 22.53 131,023 59.75 66 14 11 4 37 51.56 172.50

20180831 219,270 9,849 22.26 130,460 59.50 65 12 12 4 37 51.48 181.50

20180824 219,270 9,887 22.18 130,812 59.66 65 12 11 5 37 51.51 180.50

20180817 219,268 9,703 22.60 130,879 59.69 65 12 11 5 37 51.53 173.50

20180810 219,268 9,736 22.52 130,670 59.59 65 12 11 5 37 51.42 173.00

20180803 219,246 9,737 22.52 130,793 59.66 65 12 11 4 38 51.94 176.00

20180727 219,183 9,706 22.58 130,716 59.64 65 12 11 4 38 51.92 172.00

20180720 219,154 9,672 22.66 131,173 59.85 66 13 11 4 38 51.92 174.00

20180713 219,154 9,734 22.51 130,863 59.71 66 14 12 2 38 51.92 183.50

20180706 219,129 9,826 22.30 131,268 59.90 67 15 12 2 38 51.98 184.00

20180629 219,129 9,985 21.95 131,142 59.85 66 14 10 2 40 52.77 200.00

20180622 219,129 9,479 23.12 131,845 60.17 65 12 10 3 40 53.12 190.00

20180615 219,129 9,381 23.36 131,895 60.19 65 12 11 2 40 53.19 182.00

20180608 219,129 9,492 23.09 132,222 60.34 65 12 11 2 40 53.33 173.50

20180601 219,129 9,571 22.90 132,194 60.33 65 12 11 2 40 53.33 177.00

20180525 219,129 9,602 22.82 131,846 60.17 65 12 11 2 40 53.19 171.50

20180518 219,129 9,641 22.73 131,831 60.16 65 12 11 2 40 53.21 172.00

20180511 219,129 9,776 22.42 131,458 59.99 65 12 12 1 40 53.06 177.00

20180504 219,129 9,907 22.12 131,414 59.97 65 12 12 1 40 53.06 179.00

20180427 219,060 9,845 22.25 131,805 60.17 65 12 12 1 40 53.28 177.00

20180420 219,025 9,853 22.23 132,065 60.30 65 12 12 1 40 53.39 177.00

20180413 219,015 9,824 22.29 131,909 60.23 65 12 12 1 40 53.31 168.50

20180403 219,009 9,822 22.30 131,479 60.03 64 11 12 1 40 53.34 171.00

20180331 219,009 9,814 22.32 131,622 60.10 64 11 12 1 40 53.40 175.50

20180323 219,008 9,822 22.30 131,211 59.91 64 11 12 1 40 53.24 169.50

20180316 219,008 9,670 22.65 132,277 60.40 64 11 11 3 39 53.16 182.00

20180309 218,993 9,618 22.77 132,715 60.60 65 12 12 3 38 52.95 180.50

20180302 218,990 9,543 22.95 132,448 60.48 64 11 13 2 38 53.07 173.00

20180223 218,990 9,559 22.91 132,519 60.51 64 11 13 2 38 53.11 163.50

20180214 218,990 9,527 22.99 132,414 60.47 64 11 13 2 38 53.06

20180209 218,990 9,421 23.24 132,496 60.50 64 11 12 3 38 53.08 173.00

20180202 218,989 9,591 22.83 131,795 60.18 64 11 12 3 38 52.75 159.00

20180126 218,989 9,671 22.64 131,518 60.06 64 11 12 4 37 52.26 151.50

20180119 218,981 9,669 22.65 131,390 60.00 64 11 13 3 37 52.28 148.00

20180112 218,978 9,713 22.54 130,602 59.64 63 12 11 3 37 52.25 146.50

20180105 218,969 9,678 22.63 129,803 59.28 61 10 11 3 37 52.31 142.00

20171229 218,964 9,689 22.60 129,890 59.32 61 10 11 3 37 52.30 143.00

20171222 218,953 9,682 22.61 129,978 59.36 61 10 11 3 37 52.29 145.50

20171215 218,953 9,687 22.60 129,911 59.33 61 10 10 4 37 52.23 144.50

20171208 218,952 9,625 22.75 129,998 59.37 61 10 10 4 37 52.26 145.00

20171201 219,225 9,662 22.69 130,414 59.49 61 10 10 4 37 52.41 146.00

20171124 219,185 9,676 22.65 130,423 59.50 61 10 10 5 36 51.98 148.50

20171117 219,033 9,706 22.57 130,107 59.40 61 10 10 5 36 51.88 150.00

20171110 219,011 9,789 22.37 129,972 59.35 62 11 10 6 35 51.11 151.00

20171103 219,009 9,714 22.55 129,808 59.27 63 12 11 5 35 51.02 150.00

20171027 219,007 9,807 22.33 129,957 59.34 63 12 11 5 35 51.09 142.00

20171020 219,007 9,780 22.39 129,986 59.35 63 12 12 4 35 51.13 143.50

20171013 219,007 9,765 22.43 129,382 59.08 63 13 12 3 35 51.02 146.50

20171006 219,007 9,793 22.36 129,096 58.95 63 13 12 3 35 50.84 148.50

20170930 219,007 9,880 22.17 128,766 58.80 63 13 12 3 35 50.65 145.00

20170922 219,007 9,966 21.98 127,915 58.41 63 13 12 3 35 50.19 146.50

20170915 219,006 9,958 21.99 127,812 58.36 63 13 12 3 35 50.16 150.00

20170908 219,002 9,994 21.91 127,658 58.29 63 13 12 3 35 50.14 149.00

20170901 219,000 10,047 21.80 126,931 57.96 62 13 11 3 35 50.12 146.00

20170825 218,962 10,111 21.66 126,600 57.82 61 12 11 3 35 50.19 143.00

20170818 218,951 10,115 21.65 127,486 58.23 63 14 11 3 35 50.21 140.00

20170811 218,936 10,209 21.45 127,359 58.17 63 14 11 3 35 50.16 143.00

20170804 218,935 10,268 21.32 127,008 58.01 63 14 11 3 35 50.11 144.50

20170728 218,935 10,216 21.43 127,480 58.23 64 15 11 3 35 50.11 151.00

20170721 218,920 10,134 21.60 127,164 58.09 63 13 12 3 35 50.05 148.00

20170714 218,917 10,112 21.65 127,052 58.04 63 13 12 4 34 49.62 142.50

20170707 218,888 10,143 21.58 127,342 58.18 63 12 12 5 34 49.59 144.50

20170630 218,884 10,151 21.56 127,493 58.25 63 11 11 6 35 49.92 147.00

20170623 218,884 10,202 21.46 127,307 58.16 63 11 11 6 35 49.83 143.50

20170616 218,884 10,252 21.35 127,075 58.06 63 11 11 6 35 49.72 139.00

20170609 218,884 10,280 21.29 127,155 58.09 63 11 11 6 35 49.76 142.50

20170603 218,884 10,246 21.36 127,174 58.10 63 11 11 6 35 49.76 146.00

20170526 218,893 10,259 21.34 127,076 58.05 63 11 12 5 35 49.74 145.50

20170519 218,893 10,226 21.41 126,966 58.00 63 11 11 6 35 49.61 144.00

20170512 218,893 10,199 21.46 126,823 57.94 63 12 11 6 34 49.32 144.50

20170505 218,893 10,177 21.51 126,892 57.97 63 12 12 5 34 49.41 149.50

20170428 218,851 10,136 21.59 127,009 58.03 63 12 12 4 35 49.91 150.50

20170421 218,850 10,098 21.67 126,936 58.00 63 12 11 5 35 49.87 156.00

20170414 218,826 10,144 21.57 125,803 57.49 61 11 11 4 35 49.92 150.50

20170407 218,817 10,177 21.50 125,663 57.43 61 11 11 4 35 49.87 157.00

20170331 218,817 10,098 21.67 124,942 57.10 60 10 11 4 35 49.73 156.50

20170324 218,817 10,103 21.66 124,883 57.07 60 10 11 4 35 49.72 163.50

20170317 218,817 10,134 21.59 124,488 56.89 62 13 11 5 33 48.42 170.50

20170310 218,817 10,347 21.15 123,163 56.29 61 13 11 5 32 47.87 172.00

20170303 218,809 10,621 20.60 122,588 56.03 60 12 11 5 32 47.91 165.50

20170224 218,809 10,752 20.35 122,299 55.89 59 12 10 5 32 48.01 162.50

20170218 218,803 10,884 20.10 122,102 55.80 59 12 11 4 32 47.97 159.50

20170210 218,773 11,051 19.80 121,553 55.56 58 11 11 5 31 47.47 151.00

20170203 218,684 11,149 19.61 121,324 55.48 58 11 12 6 29 46.67 144.00

20170126 218,672 11,131 19.65 121,319 55.48 58 11 12 6 29 46.68

20170120 218,655 11,145 19.62 121,148 55.41 58 12 11 6 29 46.68 142.00

20170113 218,617 11,079 19.73 121,318 55.49 57 12 9 7 29 47.04 142.50

20170106 218,546 11,055 19.77 121,322 55.51 57 12 9 7 29 47.09 157.00

20161230 218,535 10,898 20.05 121,383 55.54 57 12 9 7 29 47.09 161.50

20161223 218,526 10,819 20.20 121,429 55.57 57 13 8 8 28 46.74 163.50

20161216 218,508 10,752 20.32 121,121 55.43 57 13 9 7 28 46.58 165.50

20161209 218,606 10,728 20.38 121,105 55.40 57 12 9 9 27 46.07 171.00

20161202 218,606 10,099 21.65 120,728 55.23 57 13 9 7 28 46.52 187.50

20161125 218,606 10,060 21.73 121,539 55.60 59 16 8 7 28 46.65 185.50

20161118 218,606 10,106 21.63 121,665 55.65 58 14 9 7 28 46.84 188.50

20161111 218,603 10,066 21.72 121,927 55.78 57 11 11 7 28 47.08 177.50

20161104 218,592 10,227 21.37 122,124 55.87 57 11 12 6 28 47.16 162.00

20161028 218,589 10,188 21.46 121,933 55.78 57 12 11 6 28 47.14 165.00

20161021 218,589 9,888 22.11 122,673 56.12 58 12 11 6 29 47.54 170.00

20161014 218,557 9,682 22.57 123,629 56.57 59 14 11 6 28 47.50 167.00

20161007 218,557 9,649 22.65 123,616 56.56 59 14 11 6 28 47.49 187.50

20160930 218,552 9,624 22.71 124,519 56.97 61 17 10 7 27 47.02 195.00

20160923 218,549 9,786 22.33 123,390 56.46 58 14 9 8 27 47.06 200.00

20160914 218,535 9,874 22.13 123,511 56.52 58 14 9 7 28 47.51 178.00

20160910 218,535 10,018 21.81 123,257 56.40 58 14 9 7 28 47.43 182.00

20160902 218,502 9,995 21.86 123,652 56.59 59 14 10 8 27 46.96 162.00

20160826 218,476 10,062 21.71 123,633 56.59 59 14 10 8 27 46.96 170.50

20160819 218,464 10,166 21.49 123,439 56.50 59 16 9 7 27 46.97 180.00

20160812 218,464 10,219 21.38 123,308 56.44 59 15 10 7 27 46.98 184.50

20160805 218,452 10,401 21.00 122,800 56.21 58 15 9 7 27 46.99 186.50

20160729 218,436 10,613 20.58 122,679 56.16 58 15 10 6 27 47.01 184.00

20160722 218,436 10,243 21.33 125,126 57.28 62 21 8 6 27 47.35 199.00

20160715 198,401 6,999 28.35 123,533 62.26 58 16 8 6 28 52.72

20160707 198,356 6,941 28.58 123,614 62.32 58 16 8 6 28 52.73

20160701 198,337 6,686 29.66 123,539 62.29 57 16 8 6 27 52.73

20160624 195,869 6,344 30.87 121,121 61.84 51 16 8 6 21 52.13

20160617 195,869 6,400 30.60 120,698 61.62 50 15 8 6 21 52.15

20160608 195,869 6,182 31.68 121,921 62.25 48 15 7 6 20 53.07

20160604 195,869 6,186 31.66 122,028 62.30 48 14 8 6 20 53.06

20160527 195,869 6,102 32.10 122,708 62.65 48 14 7 7 20 53.28

20160520 195,869 6,098 32.12 122,675 62.63 48 14 8 6 20 53.28

20160513 195,869 6,110 32.06 122,691 62.64 48 14 8 6 20 53.28

20160506 195,869 6,128 31.96 122,737 62.66 48 14 8 6 20 53.30

20160429 195,755 6,139 31.89 122,679 62.67 48 14 8 6 20 53.34

20160422 195,739 6,143 31.86 122,773 62.72 48 14 8 6 20 53.38

20160415 190,707 5,881 32.43 120,414 63.14 47 15 7 7 18 53.14

20160408 190,662 5,910 32.26 120,618 63.26 47 15 7 7 18 53.25

20160401 190,662 5,904 32.29 120,612 63.26 47 15 7 7 18 53.26

20160325 190,657 5,863 32.52 120,612 63.26 47 14 8 7 18 53.26

20160318 190,625 5,790 32.92 120,605 63.27 47 14 8 7 18 53.30

20160311 190,582 5,669 33.62 120,694 63.33 47 14 8 7 18 53.39

20160304 190,564 5,646 33.75 120,699 63.34 47 14 8 6 19 53.97

20160226 190,542 5,622 33.89 121,018 63.51 48 15 8 5 20 54.39

20160219 190,520 5,630 33.84 121,152 63.59 48 15 8 6 19 53.88

20160205 190,509 5,616 33.92 121,420 63.73 49 16 9 5 19 53.96

20160130 190,509 5,597 34.04 120,949 63.49 48 16 8 5 19 54.03

20160122 190,509 5,584 34.12 120,907 63.47 48 16 8 5 19 54.02

20160115 190,509 5,539 34.39 120,878 63.45 48 16 8 5 19 54.04

20160108 190,458 5,466 34.84 120,069 63.04 46 14 8 5 19 54.05

20151231 190,458 5,509 34.57 119,651 62.82 45 13 8 5 19 54.06

20151225 190,458 5,350 35.60 120,315 63.17 46 14 8 5 19 54.16

20151218 190,391 5,345 35.62 119,946 63.00 45 14 8 5 18 54.01

20151211 190,377 5,269 36.13 120,456 63.27 46 15 8 5 18 54.05

20151204 190,355 5,268 36.13 121,360 63.75 47 16 8 5 18 54.21

20151127 190,352 5,025 37.88 121,783 63.98 47 16 7 5 19 54.82

20151120 190,352 4,765 39.95 122,241 64.22 47 15 9 4 19 55.01

20151113 190,350 4,704 40.47 121,777 63.98 46 15 9 2 20 55.74

20151106 190,349 4,718 40.35 121,771 63.97 46 15 9 2 20 55.74

20151030 190,326 4,713 40.38 121,770 63.98 46 15 9 2 20 55.76

20151023 190,322 4,716 40.36 121,406 63.79 45 13 10 2 20 55.78

20151016 190,300 4,720 40.32 121,549 63.87 45 13 10 2 20 55.84

20151008 190,284 4,723 40.29 121,564 63.89 45 13 10 2 20 55.84

20151002 190,283 4,734 40.20 121,566 63.89 45 13 10 2 20 55.84

20150925 190,283 4,724 40.28 121,651 63.93 45 13 10 2 20 55.89

20150918 190,248 4,735 40.18 121,747 63.99 45 13 10 2 20 55.95

20150911 190,238 4,709 40.40 121,983 64.12 45 13 10 2 20 56.07

20150904 190,212 4,739 40.14 122,029 64.15 45 13 9 3 20 56.10

20150828 190,163 4,745 40.08 122,118 64.22 45 13 9 3 20 56.16

20150821 190,125 4,781 39.77 122,146 64.24 45 13 9 3 20 56.19

20150814 190,120 4,785 39.73 121,639 63.98 44 12 9 3 20 56.19

20150807 190,105 4,753 40.00 122,290 64.33 45 12 10 3 20 56.22

20150731 190,075 4,767 39.87 122,161 64.27 45 13 9 3 20 56.23

20150724 190,043 4,776 39.79 122,157 64.28 45 13 9 3 20 56.24

20150717 190,012 4,769 39.84 122,376 64.40 45 12 10 3 20 56.27

20150709 190,001 4,765 39.87 122,373 64.41 45 12 10 3 20 56.27

20150703 189,943 4,779 39.75 122,364 64.42 45 12 10 3 20 56.29

20150626 189,904 4,749 39.99 122,144 64.32 45 12 10 3 20 56.31

20150618 189,895 4,757 39.92 121,655 64.06 44 13 8 3 20 56.47

20150612 189,848 4,758 39.90 121,635 64.07 44 13 8 3 20 56.50

20150605 189,728 4,775 39.73 121,175 63.87 43 12 8 3 20 56.53

20150529 189,712 4,747 39.96 121,179 63.88 43 12 8 3 20 56.54

20150522 189,712 4,727 40.13 121,434 64.01 43 12 8 3 20 56.67

20150515 189,712 4,720 40.19 121,462 64.02 43 12 8 3 20 56.69

20150508 189,712 4,677 40.56 121,483 64.04 43 12 8 3 20 56.66

* ÃC¦âÃѧO: ¬õ¦â-¦¨ªø, ºñ¦â-¤U­°, ¶Â¦â-«ù¥­

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Lisa Astor

Published Online:4:00 PM, Thu March 19, 2020

www.targetedonc.com/news/management-strategies-set-for-varying-patterns-of-ruxolitinib-progression-in-myelofibrosis

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Dr. Rampal on Unmet Needs in Myelofibrosis and Polycythemia Vera

Raajit K. Rampal, MD, PhD

Published: Tuesday, Jan 14, 2020

www.onclive.com/onclive-tv/dr-rampal-on-unmet-needs-in-myelofibrosis-and-polycythemia-vera

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JAK Inhibition Continues to Push Progress (´c¤Æ) in Myelofibrosis

Ellie Leick

Published: Thursday, Sep 12, 2019

www.onclive.com/conference-coverage/soho-2019/jak-inhibition-continues-to-push-progress-in-myelofibrosis

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www.targetedonc.com/news/ropeginterferon-alfa2b-appears-effective-in-polycythemia-vera-without-splenomegaly

Ropeginterferon Alfa-2b Appears Effective in Polycythemia Vera Without Splenomegaly

Danielle Ternyila

Published Online:5:52 PM, Tue March 17, 2020

Based on the durable hematological and molecular response and the tolerability observed with ropeginterferon alfa-2b in the PROUD-PV trial, Gisslinger et al concluded that the agent is a safe for long-term treatment of PV with features distinct from hydroxyurea.

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Published 17 March 2020

News > Latin America

Cuba¡¦s Interferon Alpha 2B, Successful in Treating COVID-19

For 40 years, Cuba has been using a molecule named Interferon Alpha 2B , which has successfully been used to combat the new Coonavirus in China and elsewhere.

The world has an opportunity to understand that health is not a commercial asset but a basic right, Cuban doctor Luis Herrera, the creator of the Interferon Alfa 2-B medication, one of the most successful medications in the fight against COVID-19 told teleSUR Tuesday.

RELATED:

Chile¡¦s Communist Mayor to Import Cuban Meds to Fight COVID-19

Interferon has been known for more than 40 years: first, it was produced from original sources in local sites, then nationally and later in the United States and even Finland.

At the beginning of the 80s, an important professor from Houston came to Cuba and advised our President Fidel Castro than the Interferon we had here was a very interesting molecule for a different purpose, Herrera told teleSUR.

Then a group of people went to Finland to get training in the production of interferon, while people were also producing Interferon from recombined sources using genetic engineering.

The first one was Beta Interferon in Japan, and the second one was the family of Alpha Interferon by Genetec in California, according to the Cuban doctor.

One year later in Cuba, we cloned different genes of Interferon from local sites, and we started to produce Interferon in 1981 and 1982, which we used in the outbreak of dengue fever, and we presented the results in the United States in California.

One of the ways the virus can multiply inside the cells is by decreasing the levels of Interferon naturally produced in human cells. The molecule thus, through a different metabolic way, can create conditions to limit the replication of the virus.

During the MERS-CoV epidemic three years ago - another type of coronavirus - people realized that Interferon was decreased during the replication of the virus, highlighted Herrera.

In China, practically a few weeks after the beginning of the outbreak, people started to use Interferon in a way to avoid complications in people infected with the virus. According to Herrera, this molecule has some side effects but not too critical.

The main idea of Interferon is just to avoid complications, he told teleSUR. Young people and people with a good immuno-response perhaps don¡¦t need the medicine or people who won¡¦t have complications and respond to the virus-like any other flu, but old people or people susceptible to have a bad immuno-response will have better chances of avoiding complications by using Interferon.

He concluded that Cuba must participate in this solidarity movement with other nations, just the same way other countries have had solidarity with Cuba, especially with Latin American and African countries.

We have more physicians working abroad than practically any other country in the world, not because we are exporting anything but simply because we want to participate in building a world with better health conditions and living conditions.

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Zeta : Continue! Interferon has prevented me from getting colds and flu for five years.

Zeta : Last cruise I took I went with 9 ladies. 7 of them got the flu. I did not. Continued with my interferon.

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Maia Anderson -Tuesday, February 4th, 2020

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