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·|û¡G©t¨àÃÄ10140658 µoªí®É¶¡:2017/7/26 ¤U¤È 02:22:07
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2022.01-¤@´Á¼Æ¾Ú¤§Àu¤Æ²³ø(Y¥h¦~¤E¤ë®³³oª©À³¸Ó·|¦n¤@ÂI):ir.aslanpharma.com/static-files/2a7f1481-a0b3-47d1-87ef-e6ed30321475 2022.01-KOL²³ø:ir.aslanpharma.com/static-files/379e7107-c421-4401-b035-e43c4b682d19 2022.05.12- ir.aslanpharma.com/static-files/20941066-3bc3-418b-a970-9951565de0f2 2022.06²³ø-ir.aslanpharma.com/static-files/1c525489-d209-42c4-af7e-992f23c4251c 2022.09.15²³ø-ir.aslanpharma.com/static-files/1511fefc-ba34-4ee4-aac0-32f8bc4754a8 |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/31 ¤U¤È 04:33:44²Ä 6083 ½g¦^À³
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Lebrikizumab °ÝÃD¬O¤£Ã©w, ¨âÓADÁ{§É·|¦³«Ü¤j®t²§. ý³Ý¤T´Á´N¬O¤@ÓÁ{§ÉP<0.05//¥t¤@ÓP>0.05 In trial 1, the primary outcome was met in 43.1% of 283 patients in the lebrikizumab group and in 12.7% of 141 patients in the placebo group (P<0.001) In trial 2, the primary outcome was met in 33.2% of 281 patients in the lebrikizumab group and in 10.8% of 146 patients in the placebo group (P<0.001) Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis www.nejm.org/doi/full/10.1056/NEJMoa2206714 RESULTS In trial 1, the primary outcome was met in 43.1% of 283 patients in the lebrikizumab group and in 12.7% of 141 patients in the placebo group (P<0.001); an EASI-75 response occurred in 58.8% and 16.2%, respectively (P<0.001). In trial 2, the primary outcome was met in 33.2% of 281 patients in the lebrikizumab group and in 10.8% of 146 patients in the placebo group (P<0.001); an EASI-75 response occurred in 52.1% and 18.1%, respectively (P<0.001). www.almirall.com/documents/portlet_file_entry/4257831/300322_ORI+Lebri+pres+ENG+%2B+pres+vf.pdf/5ad7034f-0dd9-492f-eb83-1515071417de |
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·|û¡G¸Ø±i10133098 µoªí®É¶¡:2023/3/31 ¤U¤È 12:23:20²Ä 6082 ½g¦^À³
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CEO ³Å«i»{¬°°ª¾¯¶qIGA,0,1Àø®Ä¦Ü¤Ö44%.vs 15%(¹ï·Ó组) ¥Ø«e¥i¥H½T©wªº¬O Àø®Ä(ªvÀø®ÄªG)Ĺ¹LLebrikizumab¤F µ¥7¤ëªì¸Ñª¼¤F |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/31 ¤W¤È 09:48:55²Ä 6081 ½g¦^À³
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7¤ëªì¤½§iªºASLSN004 2b¸Ñª¼¼Æ¾Ú ¥«È¼ÒÀÀ¡G Y ¤@¡BIGA0,1>54%/15%(¹ï·Ó组) ADR¥Ø¼Ð»ù31¡D25¬ü¤¸¡D ¶Ò资»ù25¬ü¤¸ ¥«È25¬ü¤¸x4¸U¤dªÑ=10»õ¬ü¤¸ ¤G¡BIGA0,1=45%/15%(¹ï·Ó组) ADR¥Ø¼Ð»ù15¡ã20¬ü¤¸¡D¶Ò资»ù12¡ã16¬ü¤¸ ¥«È4.8¡ã6.4»õ¬ü¤¸¡D |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/31 ¤W¤È 09:33:03²Ä 6080 ½g¦^À³
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¨p¶Ò2000¸U¬ü¤¸¤Î8000¸U¬ü¤¸»{ªÑÅvªº¨Ì¾Ú¡Bªñ80%x300¤H 2b ªº¥¼¸Ñª¼x16¶gªvÀø«áªº¼Æ¾Ú¡D CEO ³Å«i»{¬°°ª¾¯¶qIGA,0,1Àø®Ä¦Ü¤Ö44%.vs 15%(¹ï·Ó组) ¥i«H«×°ª! ¦³1/3ªºÁ{§É¤¤¤ß±¾ASLN ¡B¦h©â¤@¨Ç¦å¡B§Y¥i¤ÀªR¦å²G¤¤ªºÃĶq¦s¶q¡B¥i¦³®Ä预测¬ÛÃö¼Æ¾Ú?!(¤£ª¾¬O§_¦p¦¹°õ¦æ?) |
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·|û¡G¬õ¹Ð¦³¹Ú10150039 µoªí®É¶¡:2023/3/31 ¤W¤È 09:22:51²Ä 6079 ½g¦^À³
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/31 ¤W¤È 08:09:33²Ä 6078 ½g¦^À³
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H.C. Wainwright Autoimmune & Inflammatory Disease Virtual Conference (Skin Diseases, Conditions and Disorders) - March 30, 2023 journey.ct.events/view/61f3dfa3-80fd-4977-954c-981a5ef92fda CEO ³Å«i¦^µªªº²Ä¤TÓ°ÝÃD¡D ¥D«ù¤H¡G³¯¤ÀªR®v(µØ¤H¡B¥Íª«³Õ¤h) °Ý¡G½Í½Í7¤ë¥÷n¸Ñª¼ªº2b AD Á{§É! µª¡G¡K预´Á°ª¾¯¶qªºIGA0,1Àø®Ä¦Ü¤Ö44% ¹ï·Ó组¬ù15%.... |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/30 ¤U¤È 10:59:46²Ä 6077 ½g¦^À³
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ASLN CEO ¥¿¨üH.C.WAINWRIGHT& CO.¨é°Ó³¯¥ý¥Í³X°Ý¡B 7¤ëªì 004 2b¸Ñª¼ CEO预´ÁIGA0,1 400mgxQ2WÀø®Ä¦Ü¤Ö(Min.)44%vs15%(¹ï·Ó组) |
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·|û¡Gªü¦Ì¤ÚìÂÎ10145310 µoªí®É¶¡:2023/3/26 ¤U¤È 02:29:12²Ä 6076 ½g¦^À³
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·|û¡Gªü¦Ì¤ÚìÂÎ10145310 µoªí®É¶¡:2023/3/26 ¤U¤È 02:17:53²Ä 6075 ½g¦^À³
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¥X°âªÑ东ªº关¨t °£¤Wªí脚ª`¤¤¥t¦³©ÜÅS¦}¦p¤U©Òz¥~¡A¥X°âªÑ东¤¤没¦³¥ô¦ó¤@个¤H¦b过¥h¤T¦~¤¤ü®¥ô过§Ú们ªº职¦ì¡B职务©Î¨ä¥L«n关¨t¡C 2023¦~2¤ë24¤é¡A§Ú们ÉO¥X°âªÑ东©Î购买¤è签订¤F单¦ì购买协议¡A®ÚÕu该协议¡A§Ú们¦P·N¦V购买¤è¥X°â¡]i¡^59,957,865ªÑ´¶³qªÑ¡]©Î¬Û当¤_2,398,314 ADS¡^©M¡]ii¡^52,401,685ªÑ´¶³qªÑ¡A¥i¦æ¨Ï预¥ý资§Uªº认ªÑ权证¡]©Î¬Û当¤_2,096,067 ADS¡^¡Aɲ®æ为¨CªÑ´¶³qªÑ0.178¬ü¤¸¡]©Î¨CADS 4.45¬ü¤¸¡^©M¨C个预¥ý资§Uªº认ªÑ权证4.4475¬ü¤¸¡C¨p¶Ò结§ô¤_2023¦~2¤ë27¤é¡C §@为¨p¶Òªº¤@³¡¤À¡A购买¤è还获±o¤F两个¥i¦æ¨Ïªº认ªÑ权证¡A总¦@¥i¦æ¨Ï276,545,560´¶³qªÑ©ÎTranche预¥ý资§Uªº认ªÑ权证¡A¥i¦æ¨Ï11,061,822 ADS¡C²Ä¤@§å认ªÑ权证¥]¬A¡]i¡^50¢Hªº认ªÑ权证¡A¦b发¦æ¦Z¤Î¤½¥¬§Ú们TREK-AD²Ä2b´Á临§É试验调¬datopic dermatitis¤¤eblasakimab¤½§i¤§¤é°_60¤Ñ内¦æ¨Ï¡A¦æ¨Ïɲ®æ为¨CADS 6.50¬ü¤¸¡A¥H¤Î¡]ii¡^50¢Hªº认ªÑ权证¡A¥u¯à¦beblasakimab¤½§i¦Z60¤Ñ内¦æ¨Ï¡A¦æ¨Ïɲ®æ°ò¤_ADSªº¥[权¥§¡É²®æ¡]VWAP¡^¡A该ɲ®æ¦beblasakimab¤½§i¦Zªº¯S©w´Á间内测¶q¡C²Ä¤G§å认ªÑ权证¦Pý©¥]¬A¡]i¡^50¢Hªº认ªÑ权证¡A¦b发¦æ¦Z¤Î¤½¥¬§Ú们计¦E进¦æªº²Ä2阶¬q·§©À验证试验调¬dfarudodstat时发¥¬¦Ü60¤Ñ内¦æ¨Ï¡A¦æ¨Ïɲ®æ为¨CADS 8.15¬ü¤¸¡C Relationships with Selling Shareholders Except as otherwise disclosed in the footnotes to the table above and as described below, none of the selling shareholders has, or within the past threeyears has had, any position, office or other material relationship with us. On February 24, 2023, we entered into the Unit Purchase Agreement with the selling shareholders, or the Purchasers, pursuant to which we agreed tosell to the Purchasers, in the Private Placement, an aggregate of (i) 59,957,865 ordinary shares (or the equivalent of 2,398,314 ADSs) and (ii)52,401,685 ordinary shares issuable upon the exercise of Pre-Funded Warrants (or the equivalent of 2,096,067 ADSs), at a purchase price of $0.178 perordinary share (or the equivalent of $4.45 per ADS) and $4.4475 per Pre-Funded Warrant. The Private Placement closed on February 27, 2023. As part of the Private Placement, the Purchasers also received two tranches of Warrants exercisable in the aggregate for up to 276,545,560 ordinaryshares or Tranche Pre-Funded Warrants exercisable for 11,061,822 ADSs. The first tranche of Warrants is comprised (i) 50% of Warrants that areexercisable upon issuance and until 60 days after the public announcement of our topline data from our TREK-AD Phase 2b clinical trial investigating eblasakimab in atopic dermatitis, or the eblasakimab announcement, at an exercise price of $6.50 per ADS, and (ii) 50% of warrants which can only beexercised within 60 days after the eblasakimab announcement at an exercise price based on the higher of $6.50 and a 50% discount to the ADSs¡¦ volume-weighted average price, or VWAP, measured across a specified period after the eblasakimab announcement. The second tranche of Warrants issimilarly comprised (i) 50% of Warrants that are exercisable upon issuance until 60 days after the public announcement of topline interim data from ourplanned Phase 2 proof of concept trial investigating farudodstat , or the farudodstat announcement, at an exercise price of $8.15 pe |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/26 ¤W¤È 08:41:39²Ä 6074 ½g¦^À³
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¥»¦¸¶Ò¸ê¤@»õ¬ü¤¸¡B¥Î388,905,110ì©lªÑ¡D ADR(1¡G25)= 388,905,110/25=15,556,204ªÑADR ¥§¡¨CªÑ6.42¬ü¤¸. |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/26 ¤W¤È 07:07:38²Ä 6073 ½g¦^À³
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¥»¦¸»{Áʪº4¤j¤½¥q»{ÁÊ(§t»{ÁÊÅvÃÒ)ì©lªÑ¼Æ//¨p¶Ò«e«ùªÑ//¥¼¨Ó«ùªÑ¦Xp 1.BVF 272¡B233¡B565 2.TANG 38,890,515//(¨p¶Ò«eì«ùªÑ26,824,625)¡B¥¼¨Ó«ùªÑ¦Xp65,715,140 3.K2¡C 38,890,515//(¨p¶Ò«eì«ùªÑ1,402,891) 4.Florian38,890,515//(¨p¶Ò«eì«ùªÑ9,131,810) ¦Xp 388,905,110// ir.aslanpharma.com/static-files/8ef0bdc0-36a2-45f0-9424-fe9c5722521d P.10 Name of Selling Shareholder Shares Beneficially Owned Prior to Offering(1) Number of Shares Being Offered SharesBeneficiallyOwnedAfterOffering(2) Number Percent Number Percent 1.Entities affiliated with BVF Partners L.P. (3) 42,445,150 9.99% 272,233,565 ¡X ¡X 2.Tang Capital Partners, LP(4) 41,134,322 9.99% 38,890,515 26,824,625 6.56% 3.K2 HealthVentures Equity Trust LLC(5) 26,466,126 6.24% 38,890,515 1,402,891 * 4.Florian Schönharting(6) 20,394,529 4.99% 38,890,515 9,131,810 2.23% * Represents benefi |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/25 ¤U¤È 03:31:05²Ä 6072 ½g¦^À³
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7¤ëªì¤½§iªºASLSN004 2b¸Ñª¼¼Æ¾Ú ¥«È¼ÒÀÀ¡G Y ¤@¡BIGA0,1>54%/15%(¹ï·Ó组) ADR¥Ø¼Ð»ù31.25¬ü¤¸¡D ¶Ò资»ù25¬ü¤¸ ¥«È25¬ü¤¸x4¸U¤dªÑ=10»õ¬ü¤¸ ¤G¡BIGA0,1=45%/15%(¹ï·Ó组) ADR¥Ø¼Ð»ù15¬ü¤¸¡D¶Ò资»ù12¬ü¤¸ ¥«È4.8»õ¬ü¤¸¡D |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/25 ¤U¤È 03:13:56²Ä 6071 ½g¦^À³
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3¬ü¤¸º¦¨ì30¬ü¤¸ªº¼ç¤O⋯7¤ë ¦b6550¥_·¥¬P¬Ý¹L¡A10¤¸/ªÑ¨p¶Ò30»õ¥x¹ô¡Aº¦¨ì100¤¸/ªÑ¡C2021/¤¸¤ë¡ã2022/02 µM«á¤T´Á¸Ñª¼¦¨¥\º¦¨ì232¡]2022/09¡^¡A¥Ø«e¦^¨ì96¤¸¡C ·|µu缐¾Þ§@ªÌ¡A¤£·|©ñ±¼¦¹10¿Â½º¦ªº¾÷·|ªº¡C Tang ¸ê¥»¤½¥q¡A§t»{ªÑÅvÃÒ¡A¦@¥[½X¨ì5¸U¤dªÑì©lªÑ¡A¥Ø«eADR¡]1:25¡^¬ù2000¤dªÑ¡C¡]²Ä¤G¤jªÑªF¡^¡A12¤ë©³«ùªÑ1072¤dªÑADR¡]1:25¡^ |
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·|û¡G©t¨àÃÄ10140658 µoªí®É¶¡:2023/3/25 ¤U¤È 02:46:47²Ä 6070 ½g¦^À³
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´«ºâ¦^´¶³qªÑ¥u¦³2.91/25*30=·s¥x¹ô3.49/ªÑ¡A¹ï«Ü¦h¦Ñ·à¤ÍÁÙ¬O«Ü¨¯Wªº»ù®æ¡F§Y¨ÏADRº¦¨ì25¶ô¤]¬O¥x¹ô30¶ô¡AÁÙ¬O¦Ñ¸Ü¤@¥y¡A§Æ±æ¦Ñ·à¤Í̳£¯à¸Ñ®M~~~~~~~~~ |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/25 ¤W¤È 10:10:18²Ä 6069 ½g¦^À³
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2022¦~¡B²Ä4©u°]³ø 2022/12/31 ²{ª÷¡G56.9¦Ê¸U¬ü¤¸ ²bÈ¡G8¦Ê36¸U¬ü¤¸ 2022¦~5100¸U¬ü¤¸¤§损¥¢(¥Dn¬ãµo¶O¥Î3600¸U¬ü¤¸¡D¥§¡¨C©u1400¸U¬ü¤¸¥ª¥k¡B ¡K¡K¥H¤W¬°¨p¶Ò¥D¦]¤§¤@ Cash and cash equivalents total $56.9 million as of December 31, 2022 |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/25 ¤W¤È 09:55:25²Ä 6068 ½g¦^À³
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¥Ø«e¸ê¥»ÃBADR¡B4¸U¤dªÑ(ADR:1:25) ¦©°£¤wµo¦æ¡B¤º³¡¿EÀy¤Îk2»{ªÑ¡B ©Ò³Ñ¬ù8000¤dªÑADR¥i¥«³õ¾P°â©Î¥]¾P¡K ³Ì°ª¶Ò2»õ¬ü¤¸¡B¥Ø¼Ð¶Ò¸ê»ù25¬ü¤¸/ADR ±À¦ô25/80%=30¬ü¤¸¤@¤@³Ì°ª¤½¥q»{¬°¥i¯àªº¥Ø¼Ð»ù¡D 2/24¨p¶Ò0.89*5=4.45¬ü¤¸(2000¸U¬ü¤¸) 2/24»{ªÑÅv(1.3-1.603)x5=6.5-9.15 (¶Ò8000¸U¬ü¤¸,7¤ë¸Ñª¼«á60¤Ñ¤º»{ÁÊ¡D Tang资¥»¤½¥q2¤ë24¤é¥ç¦³»{¨p¶Ò¡D ¬°²Ä¤G¤j«ùªÑ(2¤ë28¤é)¡B¦Xp«ùªÑ¬ù4.1¸U¤dªÑì©lªÑ¡B©MBVF¶°¹Î¬Û·í¬Ò¬°9.99% |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/25 ¤W¤È 09:13:19²Ä 6067 ½g¦^À³
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1.³Ì°ª2»õ¬ü¤¸ªº¶Ò¸êp¹º(2023/03/24´£¥X) ir.aslanpharma.com/static-files/0f9bf9a7-f0e1-4b22-9f67-4bbfa0a5dae8 SUBJECT TO COMPLETION, DATED MARCH 24, 2023 PROSPECTUS $200,000,000(2»õ¬ü¤¸ªº¶Ò¸êp¹º) Ordinary Shares American Depositary Shares representing Ordinary Shares ¤£¥]¬A¤§«e(2¤ë24¤é)³Ì°ª¨p¶Ò1»õ¬ü¤¸. ¥¼p¥t¥~¤º³¡¿EÀy¤Îk2¨p¶Òp2000¸U¬ü¤¸,¬ù50,000,000ì©lªÑ. ¤º³¡¿EÀy¶}©l»{ªÑ: ir.aslanpharma.com/static-files/80855ba6-3677-446a-ae3d-d4c0d9efb657 ¦Xp¥i¶Ò¸êª÷3.2»õ¬ü¤¸. 2.¦~³ø ir.aslanpharma.com/static-files/44f85422-f9c7-43ba-83cb-5cba2b68d8cb 2¤ë28¤é¤î, «ùªÑ¶W¹L5%ªÑªF¦³4¦ì.----p.106 ¤½¥q¤º³¡«ùªÑ5.26%(22,399,939ì©lªÑ) ¥H¤W¨Ì2023¦~2¤ë28¤é¤wµo¦æ408,681,230 ì©lªÑ. 3.²Öp¦Ü3¤ë20¤é¤wµo¦æ737,628,475ì©lªÑ ir.aslanpharma.com/static-files/8ef0bdc0-36a2-45f0-9424-fe9c5722521d p.8 Equity: Ordinary shares, $0.01 par value per share, 500,000,000 shares authorized, 348,723,365 shares issued and outstanding, actual; and 737,628,475 The number of ordinary shares outstanding in the table above is based on 348,723,365 ordinary shares outstanding as of December 31, 2022 on an actual basis and excludes: • 48,822,715 ordinary shares issuable upon the exercise of share options outstanding as of December 31, 2022 under our 2014 Employee Share Option Scheme Plan, our 2017 Employee Share Option Plan and our 2020 Equity Incentive Plan, at a weighted average exercise price of $0.26 per ordinary share; and • 1,402,891 ordinary shares issuable upon the exercise of an outstanding warrant issued in July 2021 to K2 HealthVentures Equity Trust LLC, at an exercise price of $0.5257 per ordinary share, pursuant to that certain Loan, Guaranty, and Security Agreement with K2 HealthVentures LLC in connection with the drawdown of our loan facilities. In addition, as of the date of this prospectus, 53,393,470 ordinary shares (representing 2,135,738 ADSs) have been issued to JPMorgan Chase Bank, N.A., as depositary, which are being held for future sales and issuances of ADSs, if any, under that certain Open Market Sale AgreementSM that we entered into with Jefferies LLC on October 9, 2020, as amended from time to time. ¤Wªí¤¤µo¦æ¦b¥~ªº´¶³qªÑ¼Æ¶q¬O®Ú¾ÚºI¦Ü2022¦~12¤ë31¤éµo¦æ¦b¥~´¶³qªÑ348,723,365ªÑ¹ê»Ú °ò¦¨Ã±Æ°£¡G • ºI¦Ü 2022 ¦~ 12 ¤ë 31 ¤é¡A®Ú¾Ú§Ú̪º 2014 ¦~¥¼¦æ¨ÏÁʪÑÅv¡A¥iµo¦æ 48,822,715 ªÑ´¶³qªÑ û¤uªÑ²¼´ÁÅvp¹º¡B§Ú̪º 2017 ¦~û¤uªÑ²¼´ÁÅvp¹º©M§Ú̪º 2020 ¦~ªÑÅv¿EÀyp¹º¡A«ö¥[Åv ¥§¡¦æ¨Ï»ù¬°¨CªÑ´¶³qªÑ 0.26 ¬ü¤¸¡F ©M • 1,402,891 ªÑ´¶³qªÑ¥i¦b 2021 ¦~ 7 ¤ë¦V K2 HealthVentures Equity Trust µo¦æªº¥¼¦æ¨Ï»{ªÑÅvÃÒ¦æ¨Ï«áµo¦æ LLC¡A®Ú¾Ú»P K2 ñqªº¯S©w¶U´Ú¡B¾á«O©M¾á«O¨óij¡A¦æ¨Ï»ù¬°¨CªÑ´¶³qªÑ 0.5257 ¬ü¤¸ HealthVentures LLC ³B²z§Ú̶U´ÚÃB«×ªº´£¨ú¡C ¦¹¥~¡AºI¦Ü¥»©ÛªÑ»¡©ú®Ñµo¥¬¤§¤é¡A¤w¦V¼¯®Ú¤j³q»È¦æµo¦æ 53,393,470 ªÑ´¶³qªÑ¡]¬Û·í©ó 2,135,738 ªÑ¬ü°ê¦s°U¾ÌÃÒ¡^¡A N.A.¡A§@¬°«OºÞ¤H¡A®Ú¾Ú§Ú̽T©wªº¬Y¨Ç¤½¶}¥«³õ¾P°â¨óijSM¡A¬°¥¼¨Ó¾P°â©Mµo¦æ ADS¡]¦pªG¦³¡^¦Ó«ù¦³ ©ó 2020 ¦~ 10 ¤ë 9 ¤é»P Jefferies LLC ñq¡A¨Ã¸g¤£®É×q¡C shares issued and outstanding as adjusted |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/23 ¤W¤È 10:09:49²Ä 6066 ½g¦^À³
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ASLAN004 2B AD ³Ì·s²§°Ê: °±¤î¦¬®×,¹ê»Ú¦¬®×302¤H,6¤ë30§¹¦¨¥Dn(16¶g)Á{§É. clinicaltrials.gov/ct2/show/NCT05158023 Phase 2b Study of ASLAN004 in Adults With Moderate-to-Severe Atopic Dermatitis Study Type : Interventional (Clinical Trial) Actual Enrollment : 302 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: A Randomized, Double-Blind, Placebo-Controlled, Multicenter, Dose-Ranging Trial to Evaluate the Efficacy and Safety of ASLAN004 in Adult Patients With Moderate-to-Severe Atopic Dermatitis Actual Study Start Date : March 16, 2022 Estimated Primary Completion Date : June 30, 2023 Estimated Study Completion Date : September 30, 2023 |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/16 ¤W¤È 08:54:17²Ä 6065 ½g¦^À³
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·|û¡G³v®ö«È10146323 µoªí®É¶¡:2023/3/13 ¤U¤È 10:26:06²Ä 6044 ½g¦^À³
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/13 ¤W¤È 10:15:30²Ä 6040 ½g¦^À³
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2020/08/25 ADR:ì©lªÑ=1:5 ,1/5=0.20 2023/03/13 ADR:ì©lªÑ=1:25, 1/25=0.04 ¤µ¤Ñªº¥½L»ù=0.571*5=2.855¬ü¤¸ ú³°Ó¥Ø¼Ð»ù²z½×¤W¬°: 3*5 ~ 4.5*5=15~22.5¬ü¤¸ |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/9 ¤U¤È 08:51:17²Ä 6038 ½g¦^À³
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ASLN is undergoing a reverse split of 1:5 on March 13 ASLN¦b3¤ë13¤é¶i¦æ1:5ªº¤Ï¦V©î¤À(´î¸ê) www.nasdaq.com/market-activity/stock-splits |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/7 ¤W¤È 11:52:35²Ä 6037 ½g¦^À³
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2023¦~/3¤ë6¤é ¤î ¤wµo¦æ424,870¤dªÑì©lªÑ/(84,974 ¤dªÑADR) BVF ¶°¹Î¦û9.99%«ùªÑ.¬ù8500¤dªÑADR(1:5) ¥¼¥]§t»{ªÑÅv: ¬ù38,000¤dªÑADR,1A/1B/2A/2B, 1A/1B(004¸Ñª¼)¦û55%)// 2A/2B(003¸Ñª¼)¦û45% BVF¶°¹ÎÁ`«ùªÑ(§t»{ªÑÅv)¹F¬ù46,500¤dªÑADR, ¦û¥¼¨ÓÁ`µo¦æªÑ20¸U¤dªÑADR(1:5)¬ù23% |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/7 ¤W¤È 08:54:40²Ä 6036 ½g¦^À³
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ir.aslanpharma.com/static-files/600458ef-6f6c-4770-9d91-5d1e3f8930c7 3¤ë6 ¤é, »{ªÑÅv10®a¤½¥q(2Ó¶°¹Î)ªº¸Ô²ÓªÑ¼Æ,95%¥H¤W¶°¤¤¦bBVF¶°¹Î. ¥»¦¸¨p¶Ò59,957,865ì©lªÑ/(11,991¤dªÑADR). ¤wµo¦æ424870¤dªÑì©lªÑ/(84,974 ¤dªÑADR) ¥H¤U¦Ê¤À¤ñ°ò©ó¤À¥À¡A¤À¥À¬°¡G(i) ºI¦Ü 2022 ¦~ 6 ¤ë 30 ¤éªº 348,723,365 ªÑ¤wµo¦æªÑ²¼¡A ³o¬Oµo¦æ¤H¦b¦VÃҨ鴣¥æªº 424B5 ªí®æªº©ÛªÑ»¡©ú®Ñ¤¤©ÜÅSªº¤wµo¦æªÑ¥÷Á`¼Æ¡A¥H¤Î ¥æ©ö©eû·|©ó 2022 ¦~ 9 ¤ë 30 ¤é¡A(ii) 59,957,865 ªÑ¦]µo¦æ¤Hªº¨p¶Òµo¦æ¦Óµo¦æªº ©ó 2023 ¦~ 2 ¤ë 24 ¤éÃö³¬¡A¦p 2023 ¦~ 2 ¤ë 24 ¤é¦V¬ü°êÃÒ¨é¥æ©ö©eû·|´£¥æªº 6-K ªí®æ¤¤ªºµo¦æ¤H³ø§i¤¤©Òz (iii) 16,190,000 ªÑ³ø§i¤H¾Ö¦³ªº¬Y¨Ç¹wª`¸ê»{ªÑÅvÃÒªº¬ÛÃöªÑ¥÷¡]¦p¾A¥Î¡^¡C The following percentages are based on a denominator which is the sum of: (i) 348,723,365 Shares outstanding as of June 30, 2022, which is the total number of Shares outstanding as disclosed in the Issuer¡¦s Prospectus on Form 424B5 filed with the Securities and Exchange Commission on September 30, 2022, (ii) 59,957,865 Shares issued in connection with a private placement by the Issuer that closed on February 24, 2023 as reported in the Issuer¡¦s Report of Foreign Issuer on Form 6-K filed with the SEC on February 24, 2023 and (iii) 16,190,000 Shares underlying certain Pre-Funded Warrants owned by the Reporting Persons, as applicable. |
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ir.aslanpharma.com/static-files/5af23249-0b59-4bb1-95eb-199556171feb 6¤Hªº400mg ²Õ, EASI90 °ª¹F67% ¤@¯ë¤T´Á16¶gªºÁ{§ÉÀø®Ä ¹FEASI90 ªº¤ñ²v§C©óIGA0,1 1.Dupilumab ¤T´Á ¤GÓÁ{§É: IGA0/1 38%/36% EASI90 36%/30% www.nejm.org/doi/full/10.1056/nejmoa1610020 2.Lebrikizumab IGA0/1 43%/33.1% EASI90 38.1%/30.2% www.almirall.com/documents/portlet_file_entry/4257831/300322_ORI+Lebri+pres+ENG+%2B+pres+vf.pdf/5ad7034f-0dd9-492f-eb83-1515071417de IGA0,1: °ò½u©Û¦¬IGA0,1=4 ©Î3. §¹¥þ²M°£=IGA0 ¨ä¤¤¦³¤@³¡¦ì¨S§¹¥þ²M°£,IGA=1 ¨ä¤¤¦³¤G³¡¦ì¨S§¹¥þ²M°£,IGA=2 ¨ä¤¤¦³¤T³¡¦ì¨S§¹¥þ²M°£,IGA=3 ¨ä¤¤¦³¥|³¡¦ì¨S§¹¥þ²M°£,IGA=4 ¨Åé¦@¤À¥|¿³¡¦ì. IGA0,1,ªí¥Ü0©Î1Ó³¡¦ì©|¥¼§¹¥þ²M°£. ------------------------------- EASI¿Å¶q¨t²Î ¥þ¨¥ç¤À¥|Ó³¡¦ì, ¨CÓ³¡¦ì³Ì°ª18¤À,(¦³¼ÆÓ¤p¶µ¥Ø: ¬õ¯l...) --------------------------------- IGA0/1 38%.36% EASI90 34%/32% |
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IGA 0/1¥NªíÁ{§Éªv·U²v¡A 004¦b1b 8week Mitt 400mg¹êÅç²ÕVS¹ï·Ó²Õ¬°14%:15% 600mg¹êÅç²ÕVS¹ï·Ó²Õ¬°44%:15% ©Ò¥H¤Ñ©R¤j¤~¥Î44¢H§@¬°IGA 0/1ªº´Á«ÝÈ Dupilumab¬O¦b²Ä12 week¤~¹F¨ìÅãµÛ ¹ï¤ñ©óLeb. 2b 8week IGA 0/1¹êÅç²ÕVS¹ï·Ó²Õ¬°31%:5%¡]26¢H¡^ 2b 16week IGA 0/1¹êÅç²ÕVS¹ï·Ó²Õ¬°45%:15%¡]30¢H¡^ IGA 0/1»Ýn®É¶¡¨Ó±À¶i¡Kµ¥«ÝÁ{§É¼Æ¾Ú¨Ó¸Ñµª |
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www.globenewswire.com/news-release/2022/01/05/2361507/0/en/Connect-Biopharma-Reports-Detailed-Positive-Dataset-from-the-Global-Phase-2b-Trial-of-CBP-201-in-Adult-Patients-with-Moderate-to-Severe-Atopic-Dermatitis.html CBP201 2B IGA0,1 28.1% VS 10.7% (¬Û®t17.4%) °ò½u¦ôEASI25 2.Dupilumab ¤T´Á IGA0,1 ¤GÓ¤T´Á©M¹ï·Ó²Õ¬Û®t28% (38%/10%) (26%/8%) 3.Lebrikizumab mmm ¤T´Á¨âÓÁ{§ÉIGA0,1 www.almirall.com/documents/portlet_file_entry/4257831/300322_ORI+Lebri+pres+ENG+%2B+pres+vf.pdf/5ad7034f-0dd9-492f-eb83-1515071417de AdvO.1 43%VS12.8%(29.6%) ADVO.2 33.1%VS12.9%(22.2%) °ò½u: EASI28.8/29.7 °ê»Ú¤W¬Ýªº¬O©M¹ï·Ó²Õªº¬Û´î®t²§.¤Îµ´¹ïªº¤ñ²v CBP201 ªº¤¤°ê2bÁ{§É¤v°µ§¹,IGA0,1 ¥ý«e®t¤£¦h, ¥Ø«e¶Ò¤£¨ì¤T´Á¸êª÷¬O¨Æ¹ê. |
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CNTB CBP2012b IGA0,1 29%vs10%(¹ï·Ó组)¡A¬ù¬°2.9¿ ASLAN004¦p¸¨¦b IGA0,1 44%vs15%(¹ï·Ó组)¡A¬ù¬°2.93¿ ¹ïCNTB¦³¦óÀu¶Õ¦s¦b¡H |
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¤½¥q9/15¤é¡BR and D day °²³]°ª©ódupilumab 8% À³¬O¦X²z预´Á¡D ¤½¥q¤@ª½±j½Õ³s¦X¤G½uAD¡B¥i¦¨¬°¤@½uº¿ï¡D ©Ò¥H¸¨¦bIGA0,1=44%/15%(¹ï·Ó组) ¾÷·|«D±`¤j¡D ¸¨¤JCBP201§CÀø®Ä组¡B«D±`§C¡D §_«hBVP¤ÎK ¤½¥q¡B¤£·|¥æ2000¸U¬ü¤¸¡D¶R¶i23%¤äªÑ¡B联¦X8000¸U¬ü¤¸ªº»{ªÑÅv§Q¡D ³oºØ¤½¥q«Ü¼F®`ªº¡D |
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¥Ø«e¥«³õµ¹ASLN ªº¥«»ù¡B´N¦p¦PCNTB ¥¼¨Ó004¸Ñª¼ªºÀø®ÄY¦pCBP201, ¥iÃø¶Ò¤T´Á¸êª÷¡D ½Ð±Ð¤Ñ©R¤j¤j ´N±z¤â¤W²{¦³¸ê°T ¥¼¨Ó004¸Ñª¼ªºÀø®ÄÀu©óCBP201 ªº¾÷·|¬O¦p¦ó??? |
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BVF ¤½¥q¶ÈºÞ²z49»õ¬ü¤¸ªº¤p¤½¥q¡D ASLN³Q¨ÖÁʪºÁͶդ£ÅÜ!(³Ì¥i¯à状ªp) ¦³¤组¥¼¸Ñª¼ªº¼Æ¾Ú²V¦b¤@°_¡B¹ê¦b¤£ª¾³Ì¦n¤@组·|°ª¨ì¨º¸Ì¡D Lebrikizumab 2b IGA0,1 Q2Wx250mg=44% Q4Wx250mg=33% ¹ï·Ó组=15% ¥H¤W¥¼¸Ñª¼ªº¼Æ¾Ú²V¦b¤@°_¡B¹ê¦b¤À¤£¥X¡D ¥»¦¸¨p¶Ò0.89¬ü¤¸¡D ASLN¥«È8900¸U¬ü¤¸¡D ©MCNTB 7000¸U¬ü¤¸¥«È®t¤£¦h¡D CNTB CBP2012b IGA0,1 ¶È 29%vs10%(¹ï·Ó组) EASI75=47% ¥Ø«e¥«³õµ¹ASLN ªº¥«»ù¡B´N¦p¦PCNTB ¥¼¨Ó004¸Ñª¼ªºÀø®ÄY¦pCBP201, ¥iÃø¶Ò¤T´Á¸êª÷¡D |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/6 ¤W¤È 09:03:18²Ä 6024 ½g¦^À³
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BVF is based out of San Francisco. BVF is a hedge fund with 5 clients and discretionary assets under management (AUM) of $4,920,045,461 (Form ADV from 2022-03-31). Their last reported 13F filing for Q4 2022 included $2,369,483,196 in managed 13F securities and a top 10 holdings concentration of 45.23%. BVF¡¦s largest holding is MoonLake Immunotherapeutics with shares held of 21,751,284 whalewisdom.com/filer/bvf-inc-il |
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BVF ¤½¥qªº¨p¶Ò³æ»ù0.178¬ü¤¸/ì©lªÑ ,ADR(1:25) ¦¨¥»4.45¬ü¤¸. *** purchase price of $0.178 per Ordinary Share ADR ,1:25 0.178*25=4.45¬ü¤¸------ BVF ·sªºADR¦¨¥» -------------------------------------------------------------------- ASLAN Pharmaceuticals Announces Private Placement On February 24, 2023, ASLAN Pharmaceuticals Limited (the ¡§Company¡¨) entered into a Unit Purchase Agreement (the ¡§Purchase Agreement¡¨) with fund entities affiliated with BVF Partners L.P. (collectively, ¡§BVF¡¨) and the other purchasers named therein (the ¡§Purchasers¡¨), pursuant to which the Company agreed to sell to the Purchasers, in a private placement offering, an aggregate of (i) 112,359,550 ordinary shares, par value $0.01 per share (the ¡§Ordinary Shares¡¨), and (ii) pre-funded warrants (the ¡§Pre-Funded Warrants¡¨) to purchase five Ordinary Shares (represented by the Company¡¦s American Depositary Shares (¡§ADSs¡¨)) at a purchase price of $0.178 per Ordinary Share (or the equivalent of $0.89 per ADS) and $0.8895 per Pre-Funded Warrant, respectively, which represents a 15% premium to the ADSs¡¦ ten-day volume-weighted average price (¡§VWAP¡¨) (the ¡§Private Placement¡¨). Each ADS represents five Ordinary Shares. The Private Placement is expected to close on or about February 27, 2023 (the ¡§Closing¡¨), subject to customary closing conditions. ir.aslanpharma.com/financial-information/sec-filings/ |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/4 ¤W¤È 09:29:00²Ä 5997 ½g¦^À³
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ASLAN Pharmaceuticals Announces Private Placement On February 24, 2023, ASLAN Pharmaceuticals Limited (the ¡§Company¡¨) entered into a Unit Purchase Agreement (the ¡§Purchase Agreement¡¨) with fund entities affiliated with BVF Partners L.P. (collectively, ¡§BVF¡¨) and the other purchasers named therein (the ¡§Purchasers¡¨), pursuant to which the Company agreed to sell to the Purchasers, in a private placement offering, an aggregate of (i) 112,359,550 ordinary shares, par value $0.01 per share (the ¡§Ordinary Shares¡¨), and (ii) pre-funded warrants (the ¡§Pre-Funded Warrants¡¨) to purchase five Ordinary Shares (represented by the Company¡¦s American Depositary Shares (¡§ADSs¡¨)) at a purchase price of $0.178 per Ordinary Share (or the equivalent of $0.89 per ADS) and $0.8895 per Pre-Funded Warrant, respectively, which represents a 15% premium to the ADSs¡¦ ten-day volume-weighted average price (¡§VWAP¡¨) (the ¡§Private Placement¡¨). Each ADS represents five Ordinary Shares. The Private Placement is expected to close on or about February 27, 2023 (the ¡§Closing¡¨), subject to customary closing conditions. ir.aslanpharma.com/financial-information/sec-filings/ 2/24¤W¶Ç¬üSECªº¨p¶Ò¸ê®Æ¡B¦³ª`©úì©lªÑ¡B¤ÎADR³æ«K¡B¤Î5´«1ªº´«ªÑ¤ñ¨Ò¡D |
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·|û¡GªL®õ10030886 µoªí®É¶¡:2023/3/4 ¤W¤È 09:15:05²Ä 5996 ½g¦^À³
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¥H¤W¬OÓ¤H´¢´ú ¦pªGadr´î¸ê«á ¿ï¾ÜÅv»ùÁÙ¬O1.6 ¥u¯à»¡¤½¥q¯Ê¸êª÷ ¥u¯à¥ô°Ñ»P¶Ò¸êªÌ®_¨î |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/4 ¤W¤È 09:10:12²Ä 5995 ½g¦^À³
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¤§«eASLN¹ï¥~¶Ò¸ê¡B³æ»ù·|¦P®Éñì©lªÑ¤ÎADR³æ»ù¡D |
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·|û¡GªL®õ10030886 µoªí®É¶¡:2023/3/4 ¤W¤È 09:07:32²Ä 5994 ½g¦^À³
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¦pªGadr ¿ï¾ÜÅv»ù®æ´î¸ê«áÁÙ¬O1.6 BVF ·|Áȫܤj ¦P®É¤]·t¥Ü ¤U¶g¤@ªÑ»ù·|¥Ñ3 ÂI¦h©¹ 1.6 ¤U¦æ |
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·|û¡GªL®õ10030886 µoªí®É¶¡:2023/3/4 ¤W¤È 08:56:22²Ä 5993 ½g¦^À³
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½Ð±Ð¤Ñ©R¤j BVF 1.6 ¿ï¾ÜÅvªº»ù®æ ¬O¤£¬O¤]n¼¥H5 ¦¨¬°8 Áâ¡H |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/4 ¤W¤È 08:42:27²Ä 5992 ½g¦^À³
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´î¸ê«á, ¥¼¨Ó³Q¨ÖÁÊÁ`»ùȤ£·|ÅÜ ¨é°Óªº¥Ø¼Ð»ù¥Ñ¥Ø«e³Ì°ª4.5¬ü¤¸¡A¦Û°Ê¤Wº¦¦Ü22.5 (4.5*5=22.5)¬ü¤¸ ªø´Á´N¤£©ö¶^¦^¤@¤¸¥H¤U,³Q¨ÖÁÊ«e¤£·|¦³¦]ªÑ»ù§C©ó¤@¬ü¤¸³W«hªº¤U¥«·ÀI. |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/4 ¤W¤È 08:14:38²Ä 5991 ½g¦^À³
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ASLN ADRªÑ¼Æ´î80%, ¥Ø«eÁ`µo¦æ¶q10¸U¤dªÑ ADR ÁY¬°2¸U¤dªÑADR, ¥¼¨Ó·|¦A¼W¸ê¨ì4¸UªÑADR(100¸U¤dªÑì©lªÑ) ªÑ»ù¤U¶g¤@¶}½L»ùÀ³¬°¤µ¤é¦¬½Lªº5¿ 0.7575*5=3.79¬ü¤¸ |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/4 ¤W¤È 08:03:35²Ä 5990 ½g¦^À³
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SECTION 2.06. Effective on the date first announced by the Depositary, the number of Shares represented by each ADS shall be amended from ¡§five¡¨ to ¡§twenty-five¡¨. ADRº¦¸«Å¥¬¤§¤é°_¥Í®Ä¡A¨C¥÷ ADS ©Ò¥NªíªºªÑ¥÷¼Æ¶qÀ³¬° ¥Ñ¡§¤ªÑ¡¨×§ï¬°¡§¤G¤Q¤ªÑ¡¨¡C ir.aslanpharma.com/static-files/91342411-adb8-4daa-b914-9c495834b780 2023/03/03 ASLN ¤½¥q¸³¨Æ·|³q¹L,¦p¤W |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/2 ¤W¤È 10:47:55²Ä 5989 ½g¦^À³
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¥Ñ2/24¨p¶Ò±À¡G §¹¦¨2A·§©À©ÊÁ{§É¡A¸Ñª¼¦¨¥\«á»ùÈ¡G ASLAN003ªº»ùȼW¥[1.63-1.3=0.33¬ü¤¸¡þªÑ 0.33x20¸UªÑADR=6600¸U¬ü¤¸ªº¥«È¡A§¹¦¨60¤Hªº2AÁ{§É«á¦¨¥\«áªº³Ì§C¥«È¡C ¤@¤@¤@¤@¤@¤@ 2023-02-24 ASLAN Pharmaceuticals «Å¥¬¥Ñ BVF Partners LP ²oÀYªº 2000 ¸U¬ü¤¸¨p¶Ò°t°â¡A¨Ã¦³¥i¯àÃB¥~Àò±o°ª¹F 8000 ¸U¬ü¤¸ The first tranche of warrants is comprised (i) 50% of purchase warrants that are exercisable upon issuance and until sixty days after the public announcement of ASLAN¡¦s topline data from its TREK-AD Phase 2b clinical trial investigating eblasakimab in atopic dermatitis at an exercise price of $1.30 per ADS and ¤@¤@¤@¤@ (ii) 50% of purchase warrants which can only be exercised within sixty days after the public announcement of ASLAN¡¦s topline data from its TREK-AD Phase 2b clinical trial investigating eblasakimab in atopic dermatitis at an exercise price based on the higher of $1.30 and a 50% discount to the ADS VWAP measured across a specified period after the public announcement of data. ii) 50%ªº购买权证¡A¥u¯à¦bASLAN¤½开«Å¥¬¨ä调¬d¥ì¥¬©Ô¦è单§Üªv疗¯S应©Ê¥Öª¢ªºTREK-AD 2b´Á临§É试验ªº顶线数Õu¦Z60¤Ñ内¦æ¨Ï¡A¦æ¨Ïɲ°ò¤_1.30¬ü¤¸©M¤½开«Å¥¬数Õu¦Z¯S©w时´Á内¬ü国¦s¦«ú«证VWAP¡]¯S©w´Á¶¡ADR¥§¡»ù®æ¡^ªº50%§é¦©¡A¥H两ªÌ¤¤较°ªªÌ为ã¡C xxxVWAP¡G¦p¤½¥¬¸Ñª¼¼Æ¾Ú«áADR 10¤Ñªº¥§¡»ù®æ x50% Y¤Wº¦¦Ü¥§¡7¬ü¤¸¡A«h7x50%=3.5¬ü¤¸¨CªÑADR°µ¬°»{ÁÊ»ù¡A«D1.3¬ü¤¸¡C ¤@¤@¤@¤@ The second tranche of warrants is similarly comprised (i) 50% of purchase warrants that are exercisable upon issuance until sixty days after the public announcement of topline interim data from ASLAN¡¦s planned Phase 2 proof of concept trial investigating farudodstat at an exercise price of $1.63 per ADS and ( ¤@¤@¤@ ii) 50% of purchase warrants which can only be exercised within sixty days after the public announcement of topline interim data from ASLAN¡¦s planned phase 2 proof of concept trial investigating farudodstat at an exercise price based on the higher of $1.63 and a 50% discount to the ADS VWAP measured across a specified period after the public announcement of data. ii¡^50%ªº购买权证¡A¥u¯à¦bASLAN计¦Eªº调¬dfarudodstatªº²Ä¤G阶¬q·§©À验证试验ªº顶线¤¤´Á数Õu¤½¥¬¦Z60¤Ñ内¦æ¨Ï¡A¦æ¨Ïɲ为1.63¬ü¤¸©M数Õu¤½¥¬¦Z¯S©w时´Á内¬ü国¦s¦«ú«证VWAPªº50%§é¦©¡A¥H两ªÌ¤¤较°ªªÌ为ã¡C |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/3/2 ¤W¤È 10:35:27²Ä 5988 ½g¦^À³
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²æ¾vªvÀø120»õ¬ü¤¸¥«³õ¡]2028¦~¡^ µoªí·s¸ÜÃD ¦^ÂÐ¥»¤å ¦^¤W¥«Âd°Q½×°Ï1¶ ·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2022/6/15 ¤U¤È 10:08:55 ·|û¡G¥xÁÞ10138776 µoªí®É¶¡:2022/6/15 ¤U¤È 09:47:22²Ä 5390 ½g¦^À³ ²æ¾vªvÀø¥«³õ¤ÀªR www.coherentmarketinsights.com/market-insight/alopecia-treatment-market-1847 ¥_¬ü36»õ¬ü¤¸/¥þ²y87»õ¬ü¤¸¡]2021¦~¡^¡A¦~¦¨ªø²v5¡A3% ·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2022/6/15 ¤U¤È 10:12:43²Ä 1 ½g¦^À³ º¤ä¤fªA¨rÀYÃÄ ¢Ô¢Ò¢Ï§åã 2022/06/15 05:30 ¡e½sĶ©Pi¨Z¡þºî¦X³ø¾É¡f¬ü°ê¹«~ÃĪ«ºÞ²z§½¡]FDA¡^¤Q¤T¤é§åã¬ü°ê»sÃĤ½¥q¡u§¨Ó¡v¬ãµoªº¡u·R·Àª¢¡v¡]Olumiant¡^¥Î¨ÓªvÀøÄY«¶ê¨r±wªÌ¡A¦¨¬°¬ü°ê¨C¦~¹O¤Ê¸U¦W¨ü¡u°«cÀY¡v§xÂZªº¥Ö½§¯f¤Hªº²Ä¤@¤ä¤fªAÃÄ¡C ¶ê¨r¬O¦ÛÅé§K¬Ì¯e¯f¡A¥ô¦ó¦³Åé¤òªº³¡¦ì¬Ò¥i¯à¦¨¬°±w³¡¡A¶Ç²ÎªvÀø¥H§½³¡Ãþ©T¾Jª`®g¬°¥D¡A¥i¨ë¿E¤ò¾v¥Íªø¦ý©ö´_µo¡A¤µ¦~¦b¶ø´µ¥d¹{¼ú¨å§¾x¥X¥Ï¤Ú´x·ªiªº¼v¬P«Âº¸¥v±K´µ¤§©d§Y¬°±wªÌ¡C ¡u·R·Àª¢¡v¥H¡u¤Ú·ç´À¥§¡v¡]Baricitinib¡^¬°¾Ç¦W¤ÎÃĪ«¦¨¤À¡A¥ý¦b¤G¡³¤@¤»¦~ÀòãªvÀøÃþ·Àã©ÊÃö¸`ª¢¡A¤W¤ë¤SÀòãªvÀøªZº~ªÍª¢¦¨¦~««×±wªÌ¡C ¾Ú¹êÅçµ²ªG¡AÄY«¶ê¨r±wªÌ¦@¤@¤G¡³¡³¤H¨ü¸Õ¡A¤À¨C¤éªA¥Î¤G¡B¥|²@§J¤Î¦w¼¢¾¯²Õ¡A¤Ê¤»¶g«á¡A°ª¾¯¶q²Õªñ¥|¦¨ªø¦^¤K¦¨¤ò¾v¡B§C¾¯¶q²Õ¤Ü¤T¢Hªø¦^¤K¦¨¾v¶q |
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·|û¡G¬õ¹Ð¦³¹Ú10150039 µoªí®É¶¡:2023/3/2 ¤W¤È 10:09:03²Ä 5987 ½g¦^À³
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¥i§_½Ðª©¤W±M·~ªº¤j¤j´NFarudodstat ¦¨¥\ªº¾÷²v¡A©M¥«³õ³W¼Ò¤ÀªR»¡©ú¤@¤U |
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·|û¡Gjimmylin10141563 µoªí®É¶¡:2023/3/1 ¤U¤È 11:33:04²Ä 5986 ½g¦^À³
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·|û¡G«Ó°¶10144972 µoªí®É¶¡:2023/3/1 ¤U¤È 08:26:34²Ä 5985 ½g¦^À³
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®É¦Ü¤T¤ë Áö¤£§Æ±æ¡A¤]±o¦Ò¼{³oÓ°ÝÃD n¬O¨p¶ÒÁÙ¬OµLªk§âªÑ»ù±À¤W1¤¸¡A¸Ó¤£·|ÁÙn°f¤À³Î§a §Úı±o¯à§_¤W1¤¸¯uªº«Ü«n¡A³o¤]¬O«H¤ß©Ò¦b ¤jªÑªFÌ¥[ªo°Ú |
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·|û¡G©t¨àÃÄ10140658 µoªí®É¶¡:2023/3/1 ¤U¤È 02:10:37²Ä 5984 ½g¦^À³
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·|û¡G¥d¦b¥b¤s¸y10153098 µoªí®É¶¡:2023/2/28 ¤U¤È 09:53:49²Ä 5983 ½g¦^À³
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·|û¡G³v®ö«È10146323 µoªí®É¶¡:2023/2/28 ¤U¤È 09:52:23²Ä 5982 ½g¦^À³
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ASLAN Pharmaceuticals to Advance Novel DHODH Inhibitor Farudodstat Into Phase 2 Clinical Testing as Potential First-In-Class Treatment for Alopecia Areata ASLAN¨î药¤½¥q将±À进·s«¬DHODH§í¨î剂Farudodstat进¤J2´Á临§É测试¡A§@为ªv疗脱发¯gªºýͦb²Ä¤@类药ª« |
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·|û¡G³¯¤p©ú10152293 µoªí®É¶¡:2023/2/28 ¤U¤È 08:11:57²Ä 5981 ½g¦^À³
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aslan003 ³Ì·s¶i«× 2023-02-28 ¡Ä ASLAN Pharmaceuticals ±N·s«¬ DHODH §í»s¾¯ Farudodstat ±À¶i 2 ´ÁÁ{§É¸ÕÅç¡A§@¬°´³¨rªº¼ç¦b¤@¬yªvÀøÃĪ« ´³¨r (AA) ¬O¤@ºØ±`¨£ªº¦Û¨§K¬Ì©Ê¯e¯f¡A¦b¬ü°ê¼vÅT¶W¹L 700,000 ¦W±wªÌ¡A¨ä¯f¦]¬O¤òÅn¤¤§K¬Ì¯SÅv (IP) ªº³à¥¢¥H¤ÎÀH«á¤Àªc IFN£^ ªº§K¬Ì²ÓMªº§ðÀ» Farudodstat ¬O¤@ºØ¦³®Äªº¤fªA DHODH §í»s¾¯¡A¤w³QÃÒ©ú¥i§í¨î IFN£^ ¤Àªc¡A´î¤Ö§K¬Ì²ÓM¼W´Þ¡A¨Ã¥i¯à¦b¤HÃþ AA ¯e¯f¼Ò«¬¤¤¨¾¤î IP ±Y¼ì AA ¤¤ farudodstat ªº 2 ´Á·§©ÀÅçÃÒ¸ÕÅç¹wp±N©ó 2023 ¦~²Ä¤G©u«×¦b¬ü°ê¶}©l©Û¶Ò±wªÌ ASLAN ±N©ó¬ü°êªF³¡®É¶¡ 2023 ¦~ 3 ¤ë 16 ¤é¤W¤È 10:00 ¡V 11:30 »PC¾|¤j¾Ç¥Ö½§¯f¾Ç°Æ±Ð±Â Brett King MD ³Õ¤h¤@°_Á|¿ìÃö©ó farudodstat ªºµêÀÀ¬ãµo¤é¡A°Q½×¾÷ºÞ§½¥¼º¡¨¬ªºÂåÀø»Ý¨D©M·í«eªºªvÀø±¡ªp ¥[§QºÖ¥§¨È¦{¸t°¨¯S¶ø©M·s¥[©Y¡A2023 ¦~ 2 ¤ë 28 ¤é¡]Àô²y·s»DªÀ¡^¡X¡X ASLAN Pharmaceuticals¡]¯Ç´µ¹F§JªÑ²¼¥N½X¡GASLN¡^¡A¤@®aÁ{§É¶¥¬q¡B±Mª`©ó§K¬Ì¾Çªº¥Íª«»sÃĤ½¥q¡A¶}µo³Ð·sÀøªk¥H§ïÅܱwªÌªº¥Í¬¡¡A¤µ¤Ñ«Å¥¬ ¥¦¥¿¦b±À¶i¨äÁ{§Ép¹º¡A¥H¬ã¨s¤fªA¤G²B¨Å²M»Ä²æ²B酶 (DHODH) §í»s¾¯ farudodstat¡A§@¬°´³¨r (AA) ªº¼ç¦b¤@¬yªvÀø¤èªkªº²Ä 2 ¶¥¬q·§©ÀÅçÃÒ¸ÕÅç¡C AA ¬O¤@ºØ¦Û¨§K¬Ì©Ê¯e¯f¡A¨ä¯S¼x¬O¤òÅn¤¤§K¬Ì¯SÅv (IP) ªº³à¥¢¡A³q¹L I Ãþ¥Dn²Õ´¬Û®e©Ê½Æ¦Xª« (MHC I) ªí¹Fªº¼W¥[¨Ó¿Å¶q¡A¨Ã¥B¬O¥Ñ¤zÂZ¯À£^ (IFN£^) ªº¿E¬¡©M¼W´ÞÅX°Êªº -¤Àªc§K¬Ì²ÓM¤¶¾É¤òÅnªº§ðÀ»¡A¾ÉPÀY¥Ö©M¨Å駹¥þ©Î³¡¤À²æ¾v¡C AA »PÄY«ªº¤ß²zt¾á¬ÛÃö¡AªvÀø¿ï¾Ü¦³¡A¼vÅT¬ü°ê¶W¹L 700,000 ¦W±wªÌ¡C §í¨î DHODH ¬OªvÀø¦hºØ¦Û¨§K¬Ì©Ê¯e¯fªº¬J©w¾÷¨î¡C DHODH §í»s¾¯¤wÀò§åã¨Ã¼sªx¥Î©ó¦hµo©Êµw¤Æ¯g©MÃþ·Àã©ÊÃö¸`ª¢¡A¦ý²Ä¤@¥N§í»s¾¯ªº®Ä¤O©M¦w¥þ©Ê¯Ê³´¦³¡C Farudodstat ¬O¤@ºØ°ª¿ï¾Ü©Ê DHODH §í»s¾¯¡A¨ä®Ä¤O¬O¦PÃþ¤wÀò§åãÃĪ«ªº 30 ¿¡A¨Ã¥B¨ã¦³¨}¦nªº@¨ü©Ê¦w¥þ©Ê¡C Åé¥~¬ã¨sªí©ú¡Afarudodstat ¥i§í¨î§K¬Ì²ÓM¼W´Þ©M IFN£^ ªº²£¥Í¡C ³Ìªñ¦bÂ÷Åé¤HÃþ AA ¯e¯f¼Ò«¬¤¤ªºÂà¤Æ¬ã¨sªí©ú¡Afarudodstat ´î¤Ö¤F MHC I ³J¥Õ»¤¾É¡A³o¬O IP ·l¥¢ªº¼Ð»x©Ê¯S¼x¡C ¸Ó¼Ò«¬ÁÙ²£¥Í¤F¨ä¥L¥\®Ä¸ñ¶H¡Aªí©ú farudodstat ¥i¯à¼ç¦b¦a«OÅ@¤òÅn§K¨ü¿E¬¡ªº§K¬Ì²ÓMªº§ðÀ»¡C ASLAN Pharmaceuticals º®u°õ¦æ©x Carl Firth ³Õ¤hµû½×¹D¡G¡§§ÚÌ«Ü°ª¿³±À¶i farudodstat ªºÁ{§É¶}µo¡A¥¦¦³¥i¯à¦¨¬°¤@¬yªºªvÀø¤èªk¡A¸Ñ¨M´³¨r±wªÌ¥¼º¡¨¬ªº»Ý¨D¡C¡¨ ¡§¾¨ºÞ³Ìªñ¦bªvÀø¤è®×¤è±¨ú±o¤F¶i®i¡A¦ý AA Àøªkªºªø´Á¦w¥þ©Ê¤´µM¬OÂå¥Íªººn¥ô°È¡C §Ṳ́w¸g²£¥Í¤F¥O¤H¹ª»Rªº¼Æ¾Ú¡A¤ä«ù§Ú̪º«H©À¡A§Y farudodstat ¥i¥H¹w¨¾¨Ã¥i¯à«ì´_¤òÅn¤¤§K¬Ì¯SÅvªº³à¥¢¡A¬° AA ´£¨Ñ¨ã¦³Ävª§¤Oªº¦w¥þ¦³®ÄªºªvÀø¿ï¾Ü¡C¡¨ 2a ´Á·§©ÀÅçÃÒ¸ÕÅç¬O¤@¶µ 2:1 ÀH¾÷¸ÕÅç¡A±wªÌ¨C¤Ñ¨â¦¸¤fªA farudodstat ©Î¦w¼¢¾¯¡A«ùÄò 12 ¶g¡AµM«á¬O¥æ¤eªvÀø´Á¡C ¸Ó¸ÕÅç±N¦b¬ü°ê©Û¶Ò¬ù 60 ¦W±wªÌ¡A¹wp±N©ó 2023 ¦~²Ä¤G©u«×¶}©l¤J²Õ¡C²Ä¤@Ó 12 ©PªvÀø´Á«áªº¤¤´Á³»½uŪ¼Æ¹wp±N©ó 2024 ¦~²Ä¤@©u«×¤½§G¡A¨Ã±N¬°«áÄò 2b ´Áªº³]p´£¨Ñ«H®§ ¾¯¶q½d³ò¬ã¨s¡C ¸Ó¸ÕÅ窺¥Dn¥Øªº¬Oµû¦ô farudodstat ¦b±w¦³ÄY«´³¨rªº¦¨¦~¨ü¸ÕªÌ¤¤ªº¦w¥þ©Ê¡B@¨ü©Ê©M¦³®Ä©Ê¡C farudodstat µêÀÀ¬ãµo¤é ASLAN ªººÞ²z¹Î¶¤±N©ó¬ü°êªF³¡®É¶¡ 2023 ¦~ 3 ¤ë 16 ¤é¬P´Á¥|¤W¤È 10:00 ¦Ü¤W¤È 11:30 »PC¾|¤j¾Ç¥Ö½§¯f¾Ç°Æ±Ð±Â Brett King MD ³Õ¤h¤@°_¦b farudodstat ¤WÁ|¿ìµêÀÀ¬ãµo¤é¡C ¶i¤@¨Bªº²Ó¸`±N¦b«á±¡C nµù¥U¸Ó¬¡°Ê¡A½Ð³æÀ»¦¹³B¡C ¬¡°Ê«¼½©Mºt¥Ü§÷®Æ±N¦b ASLAN Pharmaceutical ºô¯¸ªº§ë¸êªÌÃö«Y³¡¤À´£¨Ñ¡C Ãö©ó farudodstat Farudodstat ¬O¤@ºØ¦³®Äªº¤fªA DHODH §í»s¾¯¡A¥i³q¹LªýÂ_ DNA ½Æ»s©Ò»ÝªºáGÔr±qÀY²£¥Í¨Ó§í¨î§K¬Ì²ÓM¼W´Þ©M IFN£^ ¤Àªc¡C »P²Ä¤@¥N DHODH §í»s¾¯¬Û¤ñ¡Afarudodstat ¤w³QÃÒ©ú¦b§í¨î DHODH ©M¨î T ²ÓM¬¡©Ê¤è±ªº®Ä¤O¤j¬ù°ª¥X 30 ¿¡A¨Ã¥B¨ã¦³¨}¦nªº@¨ü©Ê¦w¥þ©Ê¡C ASLAN ¥Í¦¨ªº¼Æ¾ÚÅã¥Ü farudodstat |
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2023-02-28 003 ³Ì·s®ø®§ ASLAN Pharmaceuticals ±N·s«¬ DHODH §í»s¾¯ Farudodstat ±À¶i 2 ´ÁÁ{§É¸ÕÅç¡A§@¬°´³¨rªº¼ç¦b¤@¬yªvÀøÃĪ« ´³¨r (AA) ¬O¤@ºØ±`¨£ªº¦Û¨§K¬Ì©Ê¯e¯f¡A¦b¬ü°ê¼vÅT¶W¹L 700,000 ¦W±wªÌ¡A¨ä¯f¦]¬O¤òÅn¤¤§K¬Ì¯SÅv (IP) ªº³à¥¢¥H¤ÎÀH«á¤Àªc IFN£^ ªº§K¬Ì²ÓMªº§ðÀ» Farudodstat ¬O¤@ºØ¦³®Äªº¤fªA DHODH §í»s¾¯¡A¤w³QÃÒ©ú¥i§í¨î IFN£^ ¤Àªc¡A´î¤Ö§K¬Ì²ÓM¼W´Þ¡A¨Ã¥i¯à¦b¤HÃþ AA ¯e¯f¼Ò«¬¤¤¨¾¤î IP ±Y¼ì AA ¤¤ farudodstat ªº 2 ´Á·§©ÀÅçÃÒ¸ÕÅç¹wp±N©ó 2023 ¦~²Ä¤G©u«×¦b¬ü°ê¶}©l©Û¶Ò±wªÌ ASLAN ±N©ó¬ü°êªF³¡®É¶¡ 2023 ¦~ 3 ¤ë 16 ¤é¤W¤È 10:00 ¡V 11:30 »PC¾|¤j¾Ç¥Ö½§¯f¾Ç°Æ±Ð±Â Brett King MD ³Õ¤h¤@°_Á|¿ìÃö©ó farudodstat ªºµêÀÀ¬ãµo¤é¡A°Q½×¾÷ºÞ§½¥¼º¡¨¬ªºÂåÀø»Ý¨D©M·í«eªºªvÀø±¡ªp |
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·|û¡G¤Ñ©R10141925 µoªí®É¶¡:2023/2/28 ¤W¤È 09:43:03²Ä 5977 ½g¦^À³
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ASLAN Pharmaceuticals¡¦s PT cut by Piper Sandler to $3.00. ¥t¥~¤@®a¨é°Ó¥ç½Õ°¥Ø¼Ð»ù¥Ñ4¬ü¤¸¦Ü3¬ü¤¸¡D www.marketbeat.com/stocks/NASDAQ/ASLN/price-target/ ªÑ¥»§Ö³t¼êµÈµ²ªG¡D 2bÀø®Ä¡B¥«³õ预测¥i¯à±µªñLebrikizumab IGA0,1=45% vs15%(¹ï·Ó²Õ) |
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Hc Wainwright ±N¨È·à±d¥Ø¼Ð»ù½Õ° ¥Ñ7¬ü¤¸ÅÜ4.5¬ü¤¸ |
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HC ·Å¿à¯S½Õ¾ãªü´µÄõÃÄ«~ªº¥Ø¼Ð»ù®æ±q $4.50 ±q 7 ¬ü¤¸¡A«O«ù¶R¤Jµû¯Å ¡ã³o®a²´·ú«G¤F |
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¤½¥q¥ø¹Ï¤ß«Ü±j¡A°]°Èª¬ªpÀò±o§O®a¤½¥q¬Û®¼»P§ïµ½¨Ï¬I®i·~°ÈªºªÅ¶¡§ó¥[¶}ÂX¡A·Ó³oºØº¦´T¤ë©³´N·|¹L1¬ü¤¸¡A¤T¤ë¹L3¬ü¤¸¡A¨ì¤C¤ë¤½§G´Á¤¤¼Æ¾Úè¦n¹L7¬ü¤¸²Å¦X§ë¸ê¾÷ºc¹w´Á¡Aµ¥«Ý¨H¨S¤w¤[ªº¨È´µÄõ}´µ¸¹°_¸¼Q¥X¡C |
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1¤¸«O½Ã¾Ô¡A´N¥æµ¹BVF Partners LP¤F.... |
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As part of the financing, the Investors will also receive two tranches of warrants initially exercisable in the aggregate for up to 55,309,112 ADSs (or pre-funded warrants). The first tranche of warrants is comprised (i) 50% of purchase warrants that are exercisable upon issuance and until sixty days after the public announcement of ASLAN¡¦s topline data from its TREK-AD Phase 2b clinical trial investigating eblasakimab in atopic dermatitis at an exercise price of $1.30 per ADS and ¤@¤@¤@¤@ (ii) 50% of purchase warrants which can only be exercised within sixty days after the public announcement of ASLAN¡¦s topline data from its TREK-AD Phase 2b clinical trial investigating eblasakimab in atopic dermatitis at an exercise price based on the higher of $1.30 and a 50% discount to the ADS VWAP measured across a specified period after the public announcement of data. ii) 50%ªº购买权证¡A¥u¯à¦bASLAN¤½开«Å¥¬¨ä调¬d¥ì¥¬©Ô¦è单§Üªv疗¯S应©Ê¥Öª¢ªºTREK-AD 2b´Á临§É试验ªº顶线数Õu¦Z60¤Ñ内¦æ¨Ï¡A¦æ¨Ïɲ°ò¤_1.30¬ü¤¸©M¤½开«Å¥¬数Õu¦Z¯S©w时´Á内¬ü国¦s¦«ú«证VWAP¡]¯S©w´Á¶¡ADR¥§¡»ù®æ¡^ªº50%§é¦©¡A¥H两ªÌ¤¤较°ªªÌ为ã¡C xxxVWAP¡G¦p¤½¥¬¸Ñª¼¼Æ¾Ú«áADR 10¤Ñªº¥§¡»ù®æ x50% Y¤Wº¦¦Ü¥§¡7¬ü¤¸¡A«h7x50%=3.5¬ü¤¸¨CªÑADR°µ¬°»{ÁÊ»ù¡A«D1.3¬ü¤¸¡C ¤@¤@¤@¤@ The second tranche of warrants is similarly comprised (i) 50% of purchase warrants that are exercisable upon issuance until sixty days after the public announcement of topline interim data from ASLAN¡¦s planned Phase 2 proof of concept trial investigating farudodstat at an exercise price of $1.63 per ADS and ( ¤@¤@¤@ ii) 50% of purchase warrants which can only be exercised within sixty days after the public announcement of topline interim data from ASLAN¡¦s planned phase 2 proof of concept trial investigating farudodstat at an exercise price based on the higher of $1.63 and a 50% discount to the ADS VWAP measured across a specified period after the public announcement of data. ii¡^50%ªº购买权证¡A¥u¯à¦bASLAN计¦Eªº调¬dfarudodstatªº²Ä¤G阶¬q·§©À验证试验ªº顶线¤¤´Á数Õu¤½¥¬¦Z60¤Ñ内¦æ¨Ï¡A¦æ¨Ïɲ为1.63¬ü¤¸©M数Õu¤½¥¬¦Z¯S©w时´Á内¬ü国¦s¦«ú«证VWAPªº50%§é¦©¡A¥H两ªÌ¤¤较°ªªÌ为ã¡C Both tranches of the purchase warrants also include a mandatory exercise provision subject to the satisfaction of certain pre-specified conditions. 这两§å购买权证还¥]¬A¤@个üL¨î¦æ¨Ï条´Ú¡A¦ý¥²须满¨¬¬Y¨Ç预¥ý«ü©wªº条¥ó¡C |
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Tang Capital Partners. Tang Capital Partners beneficially owns 26,824,625 Ordinary Shares of the Issuer, in the form of 5,364,925 ADSs. Tang Capital Partners shares voting and dispositive power over such shares with Tang Capital Management and Kevin Tang. Tang Capital Management. Tang Capital Management beneficially owns 26,824,625 Ordinary Shares of the Issuer, in the form of 5,364,925 ADSs. Tang Capital Management shares voting and dispositive power over such shares with Tang Capital Partners and Kevin Tang. Kevin Tang. Kevin Tang beneficially owns 26,824,625 Ordinary Shares of the Issuer, in the form of 5,364,925 ADSs. ð¸ê¥»¦X¹Ù¤H¡C Tang Capital Partners ¹ê¯q¾Ö¦³µo¦æ¤H 26,824,625 ªÑ´¶³qªÑ¡A§Î¦¡¬° 5,364,925 ¬ü°ê¦s°U¾ÌÃÒ¡C Tang Capital Partners »P Tang Capital Management ©M Kevin Tang ¤À¨É¹ï³o¨ÇªÑ¥÷ªº§ë²¼Åv©M³B¸mÅv¡C ð¸ê¥»ºÞ²z¡C Tang Capital Management ¹ê¯q¾Ö¦³µo¦æ¤H 26,824,625 ªÑ´¶³qªÑ¡A§Î¦¡¬° 5,364,925 Ó¬ü°ê¦s°U¾ÌÃÒ¡C Tang Capital Management »P Tang Capital Partners ©M Kevin Tang ¦@¨É¹ï³o¨ÇªÑ¥÷ªº§ë²¼Åv©M³B¸mÅv¡C ð³Í¤å¡C Kevin Tang ¥H 5,364,925 ªÑ¬ü°ê¦s°U¾ÌÃÒªº§Î¦¡¹ê¯q¾Ö¦³µo¦æ¤Hªº 26,824,625 ªÑ´¶³qªÑ¡C ir.aslanpharma.com/static-files/ba66da24-32ee-49f4-b6eb-b181b975a000 |
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Aslan Pharmaceuticals Receives Decision to Grant European Patent Titled ¡¦MALONATE SALT OF VARLITINIB (FOR THE TREATMENT OF CANCER)¡¦ ªü´µÄõ»sÃĤ½¥qÀò±o±Â¤©¼Ú¬w±M§Qªº¨M©w¡A¦W¬°¡u¥ï§Q´À¥§ªºÄ«ªG»ÄÆQ¡]¥Î©óªvÀøÀù¯g¡^¡v |
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Aslan Pharmaceuticals ¦¬¨ì±Â¤©¦W¬°¡§¤þ¤G»Ä´À¥§ªº¤þ¤G»ÄÆQ¡]¥Î©óªvÀøÀù¯g¡^¡¨ªº¼Ú¬w±M§Qªº¨M©w Aslan Pharmaceuticals Receives Decision to Grant European Patent Titled ¡¦MALONATE SALT OF VARLITINIB (FOR THE TREATMENT OF CANCER)¡¦ |
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register.epo.org/application?number=EP19790887 |
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Dupilumab/Dupixent 2022¦~Q4°]³ø¥XÄl ¬°24.5»õ¬ü¤¸¡A 2022¦~À禬²Öp86.8»õ¬ü¤¸¡A¦ô2023¦~À禬¯}¦Ê»õ¬ü¤¸¡C ³æ¦ì:¦Ê¸U¬ü¤¸ USA(¬ü°ê)// ROW (¨ä¥L°Ï°ì)//¤pp 2022 Q1 1,325.6//484.8//1,810.4 Q2 1,582.1//509.7//2,091,8 Q3 1,824.0//506.1//2,330.1 Q4. //2,450.0 ¦Xp¡C //8¡A682 |
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¥h¦~10¤ë28¤éªº²Ä¤T©u°]³ø¤w§iª¾²Ä¤G©u¤½¥¬004 2b Topline data(¸Ñª¼³ø§i). ¤½¥q¦³¨Í§ï¶iªº¬O clinicaltrials.gov/ct2/show/NCT05158023 ºô¯¸¤Wªº ¹w¦ô¤é´Á没¦³ÀH¤§§ó°Ê,¥O¤H¤£ª¾ÁÙ¦³¤@§åªñ20%¥¼°µ. ³¯¤j駡ªº¦³²z. Anticipated upcoming milestones • First patient enrolled in the TREK-DX trial by the end of 2022. • New translational data highlighting the unique effects of eblasakimab¡¦s mechanism of action will be presented in early 2023. • Topline data from the Phase 2b TREK-AD trial of eblasakimab is expected in Q2 2023. ir.aslanpharma.com/static-files/b0ccbacc-0751-41fc-a55c-dee886e7e797 |
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±Æ°£±ø¥ó¦h¤@±ø. 14.Active COVID infection at baseline. ±Æ°£ °ò½u®Éªº¬¡°Ê©Ê COVID ·P¬V¡C clinicaltrials.gov/ct2/show/NCT05158023 ¥»¦¸¼W¥[¤Wz¤@±ø©Û¶Ò®Éªº±Æ°£±ø¥ó. ±Æ°£°ò½uCOVID ·P¬VªÌ¡C ¤]³\¨üCOVID¼vÅT¤Ó¦h,¬°¸É¨¬295¤H¦Ó¦b¤@¶}©l´N¦p¦¹Á{§É³]p?! ¥h¦~¤¸¤ë¤½§G2b Á{§É¥»n¦³100Ó¦¬®×¤¤¤ß,¥B§t¼Ú¬w. Dupilumab/Lebrikizumab 2b¬Ò¥Î13Ӥ맹¦¨,¦ÓASLAN004 2¤ë¥Î¤F16Ӥ맹¦¨ªì¨B¸ê®Æ¦¬¶°. |
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clinicaltrials.gov/ct2/show/NCT05158023 Phase 2b Study of ASLAN004 in Adults With Moderate-to-Severe Atopic Dermatitis ³Ì·sÁ{§É§ó·s: 2023/01/30 1.¦¬®×¤¤¤ß¥Ñ65Ó¼W¥[¦Ü83Ó,¼W¥[¼Ú¬wªiÄõ9Ó... 2.Estimated Primary Completion Date : June 30, 2023(¥i¯àªº¸Ñª¼¤é´Á?) |
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ASLAN004 ªvÀø¦³¨Ï¥Î¹LDupilumab¡]¤G½u¥Íª«»s¾¯¡^Á{§É¹êÅç¤w¸g©ó¤W¤ë21¤é¶}©l¡C ¥Ø«e¶}³]¬ü°ê¤@Ó¤¤¤ß©Û¶Ò¤¤¡C Study of Eblasakimab in Male or Female Moderate-to-Severe Atopic Dermatitis Patients Previously Treated With Dupilumab clinicaltrials.gov/ct2/show/NCT05694884?term=Study+of+Eblasakimab+in+Male&draw=2&rank=1 Study Design Go to sections Study Type : Interventional (Clinical Trial) Estimated Enrollment : 75 participants Allocation: Randomized Intervention Model: Parallel Assignment Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor) Primary Purpose: Treatment Official Title: A Randomized, Double-Blind, Placebo-Controlled, Multicenter Trial to Evaluate the Efficacy and Safety of Eblasakimab in Male or Female Moderate-to-Severe Atopic Dermatitis Patients Previously Treated With Dupilumab Actual Study Start Date : December 21, 2022 Estimated Primary Completion Date : December 16, 2023 Estimated Study Completion Date : December 16, 2023 |
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