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A single high dose of d-serine exerted an antidepressant-like effect that was mediated by rapid AMPAR-induced mTOR signaling pathway and increased BDNF proteins, identical to that of ketamine.

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http://med.sina.com/article_detail_103_2_37429.html

¨Ó·½¡GÂåÃÄÅ]¤è¼Æ¾Ú ¡@2017-11-30

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·|­û¡G²q·Q10136148  µoªí®É¶¡:2017/11/30 ¤W¤È 10:37:46²Ä 411 ½g¦^À³
¦³¤@­Ó±M®a¯S§O¦b¥Lªº"¯«¸g¬ì¾Ç¦~«×¦^ÅU"¤¤

" Neuroscience Year in Review: Advances and Developments "

https://prahs.com/blog/2017/11/14/neuroscience-year-in-review-advances-and-developments/

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" Specific to schizophrenia treatments, what new promising medications are in the pipeline to help patients and how might these address current unmet medical needs?

HANS:

...

Another potential drug for treatment resistant schizophrenia will be NaBen (sodium benzoate) from SyneuRx International [Taiwan] Corp.) NaBen is a D-amino acid oxidase inhibitor that was granted orphan drug status for the treatment of schizophrenia patients with refractory disease in combination with clozapine

"

¶È¨Ñ°Ñ¦Ò ÁÂÁ¤j®a!

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·|­û¡G²q·Q10136148  µoªí®É¶¡:2017/11/30 ¤W¤È 10:21:55²Ä 410 ½g¦^À³
½Ð°Ñ¦Ò¬Ý¬Ý , ±z·Q¨ì¬Æ»ò?

Effectiveness of antipsychotic treatments in patients with schizophrenia

June 7, 2017

https://medicalxpress.com/news/2017-06-effectiveness-antipsychotic-treatments-patients-schizophrenia.html#nRlv

"A new study published by JAMA Psychiatry examines the comparative effectiveness of antipsychotic treatments for the prevention of psychiatric rehospitalization and treatment failure among a nationwide group of patients with schizophrenia in Sweden."

Clozapine benefits those with tx-resistant schizophrenia

December 1, 2015

https://medicalxpress.com/news/2015-12-clozapine-benefits-tx-resistant-schizophrenia.html#nRlv

" (HealthDay)¡XClozapine reduces symptoms in patients with schizophrenia who don¡¦t benefit from other antipsychotic medications, according to research published online Nov. 6 in The American Journal of Psychiatry."

Better options for people with treatment-resistant schizophrenia

November 6, 2015

https://medicalxpress.com/news/2015-11-options-people-treatment-resistant-schizophrenia.html

" In real-world settings, patients with schizophrenia whose symptoms do not respond to standard antipsychotic medications have better outcomes if they are switched to clozapine instead of another standard antipsychotic.

...

Schizophrenia is a serious mental disorder affecting up to one percent of the adult population. Antipsychotics are effective at relieving symptoms for most patients, but up to 30% do not respond well to standard treatments and are considered to have treatment-resistant schizophrenia. While trials have indicated that clozapine is effective for these cases

...

The results are encouraging and timely because the FDA recently broadened access to clozapine. In the past access was limited,

"

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The Prevalance Rate for schizophrenia is approximately 1.1% of the population over the age of 18 (source: NIMH) or, in other words, at any one time as many as 51 million people worldwide suffer from schizophrenia, including;

6 to 12 million people in China (a rough estimate based on the population)

4.3 to 8.7 million people in India (a rough estimate based on the population)

2.2 million people in USA

285,000 people in Australia

Over 280,000 people in Canada

Over 250,000 diagnosed cases in Britain

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Potential impact of cinnamon on multiple sclerosis studied

Rush scientist receives NIH grant to research the effects of the common household spice on multiple sclerosis

RUSH UNIVERSITY MEDICAL CENTER

https://www.eurekalert.org/pub_releases/2011-06/rumc-pio062211.php

Different doses of sodium benzoate were mixed into drinking water since it is highly soluble and non-toxic, and administered to the mice. Sodium benzoate suppressed the MS clinical score by more than 70 percent and inhibited incidence of MS by 100 percent in the animal model. Results of the initial studies were published in past issues of the Journal of Immunology.

Current medications to treat the symptoms of MS are Interferon-B, Copaxone and Tysabri.

"These medications are expensive, have many side effects, and are only 30-40 percent effective in patients," said Pahan.

https://clinicaltrials.gov/ct2/results?cond=multiple+sclerosis&term=sodium+benzoate&cntry1=&state1=&recrs=

https://clinicaltrials.gov/ct2/results?cond=multiple+sclerosis&term=cinnamon&cntry1=&state1=&Search=Search

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Prospects of Cinnamon in Multiple Sclerosis ( ¦×®Û¦b¦hµo©Êµw¤Æ¯g¤¤ªº«e´º )

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568834/

§@ªÌ:Kalipada Pahan 1,2

1 Department of Neurological Sciences, Rush University Medical Center, Chicago, IL 60612, USA

2 Division of Research and Development, Jesse Brown Veterans Affairs Medical Center, 820 South Damen Avenue, Chicago, IL 60612, USA

¹Ï 1 : ¥Nªí¦×®Û¹ï¦Û¨­§K¬Ì²æÅèÀT§@¥Îªº¥Ü·N¹Ï

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568834/figure/F1/

Although the etiology of MS is poorly understood, it is becoming clear that widespread inflammation, loss of regulatory T cells (Tregs), hyperactivity of autoimmune Th1 and Th17 cells, breakdown of blood-brain barrier (BBB) and blood-spinal cord barrier (BSB), and loss of neuroprotective molecules in the CNS are critical for the manifestation of demyelinating pathology in MS . Interestingly, cinnamon treatment is capable of modifying these pathological features in mice with experimental allergic encephalomyelitis (EAE), an animal model of MS .

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