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¤p©_¤j ²q·Q¤j ¤µ¤Ñ¤U¤È«ôŪ6¤ë¶K¤å,¨â¦ì«e½úªø´Á±M¬ã¡]Survival analysis¡^ Kaplan-Meier Curve, ¥Î¤ßµ{«×, ¥O¤H¨ØªA, ¦UºØ¤ÀªRªk§Ú³£¦³¿³½ì, ¥u¬O¦³¨Ç½×z,ê©ó¯à¤O,¦Û¤v©|µLªk¿s¨ä°ó¶ø,¥u¯à¦h¬Ý´X¦¸,¤µ¤Ñ§Úµo²{LR/PD 229 ¬O¯QÀs¤@³õ , ¤w¸gºâ¹L ¤£¯à±q«½Æºâ ,¤]³\¦³§U©ó¤U«¦ôp¤§°Ñ¦Ò ¬O§_n§â¤¤¥¡¼Ð·Ç¹êÅç«Çªº§PŪÂå¥Í¾Þ¨ì¦º ¦U¦ì¤j¤j ¯QÀs¤@³õ ¤w¸gºâ¹L ¤£¯à±q«½Æºâ 1¦]¬°2014 12 31 LR/PD 187 ¤w¸gºâ¹L ¤£¯à±q«½Æºâ ºâ¥XCR/PD¬O<142 142/187=76% »~®t²v24% 2 ¤£¯à2014 12 ¤ë LR/PD 187 ºâ¤@¦¸ 5¤ë LR/PD 229¦Aºâ¤@¦¸ (¦³«½Æpºâªº¶ûºÃ ,¬O§_n§â¤¤¥¡¼Ð·Ç¹êÅç«Çªº§PŪÂå¥Í¾Þ¨ì¦º) 3»Ýn¸g¦A¹L¤¤¥¡¼Ð·Ç¹êÅç«Çdouble check ¹ê»Ú¤W¥u¦³ 42¤H(¹êÅç²Õ+¹ï·Ó²Õ) LR/PD 229-187= 42 »~®t±Ä¥Î42*0.9 ©Î42*0.8 ©Î42*0.7 ©Î42*0.6, ¦p±Ä¥Î0.8 42x0.8=32¤H 32¤H-8¤H(Ó¤H¹w¦ô1¤ë¨ì5¤ë¹ï·Ó²Õ¼W¥[¤H¼Æ8¤H)=24¤H ¹w¦ô1¤ë¨ì5¤ë¹êÅç²ÕCR/PD ¼W¥[¤H¼Æ24¤H 24/5=¨C¤ë¼W¥[4.8¤H ¬Û·í¨}¦n (YK »¡: ¦b¦X²z½d³ò) ¥H¤W¶È¨Ñ°Ñ¦Ò ¦p¦³»~½Ð«ü¥¿ |
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·|û¡GFaith10138335 µoªí®É¶¡:2015/6/21 ¤U¤È 06:11:03²Ä 1476 ½g¦^À³
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¤H¯uªº»Ýn¥ð®§ °£¤F¯àÅý¦Û¤v¨I¾ý«äºü¥~¡A¤]¯à§ó«á°h¤@¨B¬Ý«Ý¨Æ±¡ ¦Û±qPD229¨Æ¥ó«á¡A¤p§Ì¯uªº³Ü¤F´XªM¡]«¢«¢«¢¡^ Åý¦Û¤v«äºü¨I¾ý«á ·Q°_Cliff¤j»¡±o¨}ÃÄ¡A·Q¨ì±i¸³»¡±oµª®×¥u¦³¤@Ó¦r ¦A¹ï·Ó¼í®õ¥þªº¶Rªk¡A¦A§âOBIºô»x¬Ý¤F´X¹M ¬ðµMµo²{....«ç»ò¨Sª`·N¨ì229¤¤¥]²[µL®Äªº ©ó¬O¤j¯º¤F¤TÁn ³oÓ°²´Á¯uȱo |
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·|û¡G¥xÁÞ10138776 µoªí®É¶¡:2015/6/21 ¤U¤È 02:46:39²Ä 1475 ½g¦^À³
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Dear ¤p¤k«Ä There are many outstanding members and potential members in berich, Positive feedback and mutual discussion help our members regain lost confidence and find the courage to change,We learn, We share and we support, undoubtedly,it will be a great memory in my life.Always look on the bright side of life ,Don¡¦t be afraid to learn ,to share, to change, May God bless you with happiness.In addition, I would like to express my sincere gratitude to your grandfather. |
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·|û¡G±i¥ò´º10140184 µoªí®É¶¡:2015/6/21 ¤U¤È 01:51:31²Ä 1474 ½g¦^À³
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Cliff ¤j¡BCliff¤j¡BCliff ¤j..¤j: ·PÁ§A¹ï¤p§Ìªº±Ð»£«ü¥¿, Y¤£¬O§A , ¤p§ÌÁÙ·|§âPFS »¡¦¨¬O ¡§ µL´_µo(©Î´c¤Æ)¦s¬¡´Á¡¨ , ¦Ó«D¡§µL´c¤Æ(©Î¦º¤`)¦s¬¡´Á¡¨¡C ¦ý¦Ü¤µ¦ü¥G¤´¦³³\¦h¯E¤Í¥Ç¤F¸ò¤p§Ì¬Û¦Pªº¿ù»~¦Ó¤£¦Ûª¾, §Æ±æ§A¯à¥X±¾É¥¿¤§; µo´§§Aªº¼vÅT¤O§a¡C ¥xÁÞ¤j¤w¸g³Ü¤U ¡§¾G«¹Dºp´ö¡¨³Æ¦nÂAªá¬ü°s, ÁܽЧA¤µ©]¨«¬P¥ú¤j¹D, ±µ¨ü¯E¤Í̪ºÅw©I, Y§A¤µ©]¤£Âk¡B©ú©]¤£¦^, ¤p§Ì®£³Q§^¬Ó ¡§¤°¨¤À«Í¡¨¤F, Cliff¤j, §A¬O¤@«~¤j¦Ú, ±oÄǤp§Ì³B, ¥BÄǤp§Ì, ¥\¼wµL¶q§r |
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·|û¡GWalden10140608 µoªí®É¶¡:2015/6/21 ¤W¤È 01:22:18²Ä 1471 ½g¦^À³
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·|û¡GWalden10140608 µoªí®É¶¡:2015/6/20 ¤U¤È 11:57:30²Ä 1469 ½g¦^À³
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¹Ç§A¤j, ±zªº¶K¤å "¦ý¤£¹L¤À¼ÖÆ[¨Ã¤£µ¥©ó´dÆ[¡A§ÚÁÙ¬O¹ï©óPFS>20²`¤Á¥ø¬ßµÛ" ......... §Ú©M±zªº·Qªk¤@¼Ë. §Ú¬O¥Î LR PD 187 / Others 26©M PD 229 / Others 37¦ôºâ M PFS¬ù 20Ó¤ë, ©Ò¥H CR©M LR¦³¦h¤Ö%ªº®t§O, ´N¬O¦h¥X¨Óªº. ¦]¦¹§ÚÃÙ¦PCliff¤j rabbit¤j ¤p©_¤jªº»¡ªk: Áö¤£¬O¥P¤¦, ¥ç¬O¨}ÃÄ; ¦Ó¥B¥i¯à±N¬O¥¼¨Ó³Ì¦nªº¥½´Á¨ÅÀùÃÄ. §Ú·Q¤¨¦ÑÁ󤣷|µL½tµL¬Gªº³{§C¥[½X, ¤]¤£³æ¯Âªº¥u¬OÅ@½L, À³¸Ó¬O¦³????? ¥xÁÞ¤j, ¨¯W±z¤F, ªá¤F¤£¤Ö®É¶¡©Mºë¯«¾ã²z¥X§¹¾ãªº¸ê®Æ,, ¨Ã¤Uµ²½×: "2017¦~2¤ë4¤é«eÀò¬ü°êFDAÃÄÃÒ". ¬Û«H¯E¤Í̳£´Á¬ß³o¤Ñ¯à¦p±z¹w´úªº¨ì¨Ó. ¤p¤k«Äªº´¼¼z©M«ä¼{¤£¬O¤@¯ë20·³¤k¾Ç¥Íªºµ{«×, ¦o¼g "¶â¡K¤£§¹¥þ¥u¬O¨î«×§a¡AÁÙ¦³Ãļt¦n¹³·N«ä¬O¤H¡A¨î¡Aªv¡A©Ò¥H¤]n«ä¦Ò¤Hªº¦]¯À". ¦o¤£¸ò¯E¤ÍÌ°Q½×, «o»´´y²H¼gªºÂI¥X«ÂI. ¤p¤k«Ä¬O¤£¬O¯uªº "¥P¤k«ü¸ô --- ¹êÅç²ÕPFS¤¤¦ì¼Æ¬O35Ó¤ë@ ---- ¨û¨û³£»¡ 822·|±Ï«Ü¦h¤H¡I" ªÑªF·|®É, ¦³¤£¤Ö¦~»´ªº¤k¥Í°Ñ¥[. |
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±q¬Ý¨ì²Ä¤@«h35°T®§¡A´N¤@ª½Ä±±oºÃ´b"³o¬O½Ö"¡A©Ò¥Hµo°Ý¡C ¦A¥J²Óªº¬Ý35³°Äò¦^¤å¤º®e¡A ¤£Â_°Ý¦Û¤v? 1/ABC¦³¨º»ò¤Ñ¯uªº»y½Õ? "µ´¥æ"~·Pı¦n¹³¤T¤Q¦~¨S¥Î¹L³oÓµü»y¡C ¯à©ÀÂå¾Ç°|ªº®a®x±Ð¨|¡A´X¥G¨S¦³¤@Ó¬O±q¤p»´ÃPªº¡A ¦Ü¤Ö¥H«e°á®Ñ¡A§Ú´N¨S¬Ý¹LþÓ¦P¾Ç¦b¤G¤Q·³¥ª¥k¡AÁÙ¬O¨º»ò¤Ñ¯uªº¡C 2/¥H²{¥N¤G¤Q·³ªº¤H¡A¤õ¬P»y«ç»ò¥Î±o¨º»ò¤Ö? 3/¤÷¥À¿Ë¾·~¡A´£¥X°ÝÃD¡A¥ÍªøÀô¹Ò¡A®a®xIµ¥¡A ¥é¦ò¬O¬°¤FÃÒ©ú¦Û¤v»¡¸Ü¦Ó³]©w¦n¡A ¤Ó²Å¦X©Ò¦³·Q¬Ý¨ì¼ÖÆ[µ²ªG¤Hªº»Ýn¡C 4/¦pªG§Ú¤£·|ºâ¡A§Ú·|°Ý¦P¾ÇÁÙ¬O°Ýª©¤Í? 5/·Pı¤£Â_¦b¬ðÅã¤j¤H»P¤p«Äªº°Ï§O¡A ¤G¤Q·³ªº¦~»´¤H¦³´XÓ·|»{¬°¦Û¤vÁÙ¬O¤p«Ä? 6/µ½¤H¤jªº´£°Ý¡A³Q¤@Ó"¤Ñ¯u¥i·R"ªº¤p¤k«Ä¥´¤Ó·¥·b±¼? ©Ç¤F¡A·|°Ý35ªº¸Ü¡A¦o¤£¬OÀ³¸Ó§ó·Qª¾¹D¶Ü? 7/²Ä¤@¦¸µo°Ýªº¤H·|«÷©R§â¦Û¤vªº©³§Ý¥X¨Ó?§¹¥þ¦³¹H±`²z! ¦Ü¤Ö¤@¯ë¤H¬O«÷©RÁôÂáC 8/¤å¦r·¾³qµ¥»ºµü¥Î»y¡A¹³Âå¾Ç°|¾Ç¥Í? ¦¹ª©¤WªÖ©w¦³«Ü¦hÂå¥Í¦b¬Ý¡A§AÌı±o? ·Q°_¨â¦~«e¡A¸ò¦P¨Æ¶¢²á¡A ¥L°Ý§Ú"¦pªG¬ðµM¶]¨ÓÓ¬ü¤k»¡¦Û¤v«ÜªY½à§Ú¡A§Ú·|«ç»ò¤ÏÀ³"? §Úªº¦^µª«Ü²³æ~ ¦pªG¤£¬O¹J¨ì°¡A´N¬O¥P¤H¸õ! ²Ä¤@¦¸ªº¯u¤ß§Æ±æ~¦Û¤v¬O¤p¤H¤§¤ß«×§g¤l¤§¸¡¡A ²¦³º§Ú¦³¤£¤Ö"ôô"¡C |
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·|û¡G£~£~10134649 µoªí®É¶¡:2015/6/19 ¤U¤È 10:25:14²Ä 1439 ½g¦^À³
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¤p¤k«Ä»¡ªº¡u«Ü¦h´c¤Æ©Î¶}©l¦n¹³´c¤Æªº¬O³£¶W¹L¢²¢¯Ó¤ë¤F¡v,³o¤@ÂI§Úı±o«Ü¥i±¤,¦]¬°§Ú»{¬°³oºØ¯f±w¦pªG¯à°÷©w´Á°l¥[°w¾¯,À³¸Ó·|¹³ºC©Ê¯f¤@¯ë,¤£·|´c¤Æ¡C½Ð°Ý¦U¦ì:±N¨ÓÃĪ«³q¹L»{ÃÒ«á,¥u¯à¬I¥´¤@ÓÀøµ{¤E°w¶Ü?¯à§_¦b¤E°w¤§«á¨C¼ÆÓ¤ë©w´Á«ùÄò¬I¥´©O? |
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·|û¡G¦Ñ¥v10140531 µoªí®É¶¡:2015/6/19 ¤U¤È 10:01:01²Ä 1438 ½g¦^À³
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¸É¥RPI88 ¤T´Á¬O¥Î¤G´ÁªºA²Õ©MB²Õ¥h°µ ¦pªGA²Õ¦¬ªº¯f¤H«ì´_¤ô·Ç¡A´_µo²v°¦^30% ¦ÓB²Õ¥ÎÃÄ«O«ù¤ô·Ç¡A´_µo²vºû«ù37%............. ¥H¤W¯ÂÄݦѥv²q´ú¡A¤@¤Á¥H©x¤è»¡©ú¬°·Ç |
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·|û¡G¦Ñ¥v10140531 µoªí®É¶¡:2015/6/19 ¤U¤È 09:51:16²Ä 1437 ½g¦^À³
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°ò¨È¤G´Á¼Æ¾Ú½Ð°Ñ¦Òhttp://www.sciencedirect.com/science/article/pii/S0168827809000567# Three groups were included: one untreated arm (Group A) and two PI-88 arms (Group B: 160 mg/day; Group C: 250 mg/day). Treatment groups received PI-88 over nine 4-week treatment cycles, followed by a 12-week treatment-free period. Safety and optimal dosage were assessed Overall, 172 patients were randomized and 168 were included in the intention-to-treat (ITT) population. Treatment-related adverse effects included cytopenia, injection site hemorrhage, PT prolongation, etc. Four serious adverse events were possibly related to PI-88 treatment. One (1.8%) group B patients and six (10.5%) group C had hepatotoxicity-related withdrawals. Among the ITT population, 29 patients (50%) in Group A, 35 (63%) in Group B, and 22 (41%) in Group C remained recurrence-free at completion. Calculated T1 value suggested 160 mg/day treatment satisfied the criteria for the next stage of the trial. A¡G¨S¥´ÃÄ¡A48¶g´_µo²v50% B¡G160mg²Õ¡A48¶g´_µo²v37% C¡G250mg²Õ¡A48¶g´_µo²v59% «ä¦Ò 1>³N«á¨xÀù¤@¦~´_µo²v¦n¹³30%¥ª¥k¡AA²Õ50%°ª±o¦³ÂI©_©Ç 2>¦³¥´ÃĪºB²Õ¤ñ¨S¥´ÃÄA²Õ¦n¤@¨Ç¡A¦ý37%´_µo²v¤]¨S¦hº}«G¡A¤@¯ë¤H¤£¥´ÃĤ]®t¤£¦h30% 3>¥´¾¯¶q§ó«ªºÃĪºC²Õ´_µo²v59%¡A¤£¯à©µªøDFS´Nºâ¤F¡AÁÙ´£°ª´_µo²v ¦p¤W¡API88¤G´Á¼Æ¾Ú¦n¤£¦n¡H |
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·|û¡G±Û«a10139522 µoªí®É¶¡:2015/6/19 ¤U¤È 09:49:49²Ä 1436 ½g¦^À³
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µ½¤H¤j¡A±z§Ñ¤FÁÙ¦³¤@Óª©¥»¡A´N¬O6¤ë5¤é¥Ñ·|û10139510¤j©Ò¶K¥Xªºª©¥»¡A±z¤£§«±ÀºV¬Ý¬Ý¡A¥i¯à±µªñ¤p¤k«Ä©ÒÁ¿ªº¬Ýªk¡A·íµM¤p¤k«Ä©ÒÅ¥»Dªºªø½ú¶È¬O¬Ý¨ì¤@ÓÁ{§ÉÂå¾Ç¤¤¤ßªº¼Æ¾Ú¡A¤´¦³¨£¾ð¤£¨£ªLªººÃ¼{¡A¦Ó¥B§Ú¤]¦P·N±z©ÒÁ¿ªº²{¤µ²³¤H¬Ýªk¸û¬°«O¦u¡A¦]¦¹¦b¤£©y»~¾É§ë¸ê¤H·Qªkªº«e´£¤U¡AÂÔ·V«O¦uªº±À¦ô¬O¥²nªº¡C |
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·|û¡G¦Ñ¥v10140531 µoªí®É¶¡:2015/6/19 ¤U¤È 09:26:28²Ä 1435 ½g¦^À³
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¥xÁÞ¥S FDA¦¬¨ìNDA©ÎBLA«á¡A¦pªG¬Oµ¹¤©¥Ó½ÐªÌpriority review¸ê®æ¡A·|¦b60¤Ñ¤º¦^ÂЧiª¾¡A ¦^ÂЫáFDA«ö³W©w·|¦b6Ӥ뤺¼f®Ö§¹²¦¡A¦pªG¬Oµ¹¤©¥Ó½ÐªÌstandard review¸ê®æ¡A·| ¦b74¤Ñ¤º¦^ÂЧiª¾¡A¦^ÂЫáFDA«ö³W©w·|¦b10Ӥ뤺¼f®Ö·sÃħ¹²¦¡C¤]´N¬O»¡¡A¼Ð·Ç¬yµ{ ¤§¤Upriority review·|¤ñstandard review§Ö4.5Ó¤ë¡CFDA¼f®Ö¶i«×ªº·ÇÂI²v±µªñ 90%¡A¤£·|¹³¥xÆW¤õ¨®±`»~ÂI¡C½Ð°Ñ¦ÒFDAºô¯¸http://www.fda.gov/AboutFDA/ReportsManualsForms/Reports/UserFeeReports/PerformanceReports/ucm209398.htm ¬ü°êªº®É¶¡¤ñ¸û¦n´x´¤¡AÅܼƦb¥xÆW¦ó®É¶}ª¼ ¦pªGPFS¸¨¦b20Ó¤ë¡AK-M¦±½uªº¼Æ¦rÀ³¤w¦¨¼ô¡A¤K¤ë±M®a·|ij«á¡A§Ú»{¬°Q4´N·|¸Ñª¼¡A ©ú¦~ªì°e¥ó¡Astandard reviewªº¸Ü¡A2017¦~2¤ë¨ú±oÃÄÃÒ¡Apriority reviewªº¸Ü¡A 2016¦~9¤ë¨ú±oÃÄÃÒ¡AY¹B®ð¦n·f¤WOpdivo¡BKeytruda§K¬ÌÀøªk¶¶·¨®¡A¤ñpriority reviewªí©wªº6Ó¤ë¦A´£¦3Ó¤ë¡A2016¦~6¤ë¤]¥i¯à ¦pªGPFS¸¨¦b25Ó¤ë¡AK-M¦±½uªº¼Æ¦r·|±ß´XÓ¤ë¤~¦¨¼ô¡A§Ú»{¬°©ú¦~Q2¤~·|¸Ñª¼¬Ý¨ì topline¡A¥H©ú¦~6¤ë°e¥ó¨Óºâ¡Astandard reviewªº¸Ü¡A2017¦~8¤ë¨ú±oÃÄÃÒ¡A priority reviewªº¸Ü¡A2017¦~3¤ë¨ú±oÃÄÃÒ¡AY¹B®ð¦n·f¤WOpdivo¡BKeytruda§K ¬ÌÀøªk¶¶·¨®¡A2016¦~12¤ë¤]¥i¯à BTDªº©Ê½è¤ñ¸û°¾«Á{§É«ü¾É¡A»PÃÄÃҥӽШS¦³¤Ó¤jÃö«Y¡A822³£§Ö°µ§¹Á{§É¤F¡A¨ú ±oBTD§U°}¤]¤£·|¥[§ÖÁ{§É³t«×¡A¦ý¬O·|´£°ªpriority reviewªº¾÷·| ¥H¤W²L¨£ |
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¥Î´XÓ¨Ò¤l¸É¥Rµ½¤H¥Sªº·Qªk ÃÄÃҥӽЩλPBTD¦³¨ÇÃö«Y¡A¦ý¥¼¥²¦³«Ü«nÃö«Y¡A¨S¦³BTD¤]¥i¥H«Ü§Ö¨ú±o®Öã ¦N§Q¼wªºZydelig 2013.6¤ë´Á¤¤¤ÀªRphase2¸ê®Æ(¦¬®×125¤H)¡A¶}©ñ¦¡Á{§É¡Asingle-arm 2013.9.11°w¹ïSLL¾AÀ³¯g´£¥XNDA¡A®t¤£¦h®É¶¡°w¹ïCLL¾AÀ³¯g¨ú±oBTD¸ê®æ 2013.12.6°w¹ïCLL´£¥XNDA ¦P¤@ÓÃÄ¡A«e«á®t¤TÓ¤ë¥Ó½Ð¨âºØ¾AÀ³¯g¡ASLL¨S¦³BTD¡ACLL¦³BTD ³Ì«á¦P®É¦b2014.7.23®Öã ¨S¦³BTDªºSLL±qNDA¨ì®Öã¬O10Ó¤ë ¨ú±oBTDªºCLL±qNDA¨ì®Öã¬O8Ó¤ë ¿ÕµØªÍÀùÃÄZykadia¡Aphase1¡Asingle-arm 2013.3¨ú±oBTD 2013.6¤½§G78¤Hªº¤ÀªR¸ê®Æ 2013.12 NDA 2014.4 ®Öã----°eNDA¨ì®Öã5Ó¤ë¡A¨ú±oBTD¨ì®Öã13Ó¤ë BMSªºOpdivo°w¹ï¶Â¦â¯À½F 2014.5¨ú±o²O¤Ú½FBTD 2014.7.10¨M©wBLA 2014.9.26FDA±µ¨üBLA¨Ãµ¹¤©priority review¸ê®æ¡A¤]µ¹¤©¶Â¦â¯À½FªºBTD¡A«ö³W©w2015.3.30«en¼f¬d§¹²¦ ³Ì«á´£«e¦b2014.12.22®Öã---- Opdivo°w¹ïªÍÀù¡AN=272¡A¹êÅç²Õ135¤H¡A¹ï·Ó²Õ¼Ú¬wµµ§ü¾J137¤H¡A¶}©ñ¦¡Á{§É 2014.4 rolling submission 2014.10.30¤½§Gphase2°w¹ï117¤Hªº¦w¥þ©Ê¸ê®Æ(BMS¦P®É¶i¦æ«Ü¦hOpdivoÁ{§É) 2012.12¤½§GÁ{§Éµ²ªG¦P®ÉBLA¨ú±opriority review¡A«ö³W©w2015.6.22«en¼f¬d§¹²¦ ´£«e¦b2015.3.4®Öã(°w¹ïªÍÀù¨S¦³¨ú±oBTD) In 2012, the FDA granted Fast Track designation for Opdivo in NSCLC, melanoma and RCC. In April 2014, the company initiated a rolling submission with the FDA for Opdivo in third-line pre-treated squamous cell NSCLC and expects to complete the submission by year-end. The FDA granted Opdivo Breakthrough Therapy Designation in May 2014 for the treatment of patients with Hodgkin lymphoma after failure of autologous stem cell transplant and brentuximab. On July 4, Ono Pharmaceutical Co. announced that Opdivo received manufacturing and marketing approval in Japan for the treatment of patients with unresectable melanoma, making Opdivo the first PD-1 immune checkpoint inhibitor to receive regulatory approval anywhere in the world. On September 26, Bristol-Myers Squibb announced that the FDA accepted for priority review the Biologics License Application for previously treated advanced melanoma, and the Prescription Drug User Fee Act goal date for a decision is March 30, 2015. The FDA also granted Opdivo Breakthrough Therapy status for this indication. |
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·|û¡GCliff10135274 µoªí®É¶¡:2015/6/16 ¤W¤È 11:33:17²Ä 1337 ½g¦^À³
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·|û¡G¥xÁÞ10138776 µoªí®É¶¡:2015/6/16 ¤W¤È 10:26:29²Ä 1336 ½g¦^À³
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¦U¦ì¤j¤j ±q Hazard Ratio ¨Ó¬Ý ¨âºØ§PŪÁÙ¬O¦³®t²§ ,±qPFS ¨Ó¬Ý¦³¨Ç¦³®t²§ ¦³¨Ç¤£©úÅã Hazard Ratio <1 log (HR) < 0 ªí¥Ü survival is better in the treatment group Hazard Ratio ¶V¤pªí¥Ü¨â²Õ®t²§¶VÅãµÛ (¹êÅç²Õ»P¹ï·Ó²Õ¤ñ¸û) Hazard Ratio >1 log (HR) > 0 ªí¥Ü survival is better in the control group Hazard Ratio =1 log (HR) = 0 ªí¥Ü two groups have the same survival experience ¹êÅç²Õ»P¹ï·Ó²Õ¤ñ¸û¨S¦³®t²§ 1¦³¤H¨¥«ªº,§Ú¥u¬O¨Ì¾Ú¼Æ¾Ú»¡©ú§PŪªº½T¦³®t²§,Åý¤j®a±q¤ß²z®£·W¤¤¯à±o¨ì¥ÀR»P²z©Ê, ¦Ü©ó¹ïPFSªº¼vÅT§Ú¤]¥þ½L´L«¶K¤åªÌªº¬Ýªk,¶K¤åªº¥Øªº¤£´N¬On¤¬¬Û°Q½×,µL¨pªº¤À¨É 2¤@Ó¤Hªº®Ö¤ßÄvª§¤O°£¤F±M·~¯à¤O¥~,¦³«Ü¤jªº¤@³¡¥÷¨Ó¦Û¦X§@ ³Ð·s ´L« ·¾³q ¥]®e , ¥Î¤£·íªº¤ñÀÀ¥h»´µøª©¤ÍªºÁ|°Ê°£¤F·|ªýê¦b¨ä¥Í²Pµo®i¥~¤]Åýª©¤Í¬Ý²M¨ä´L«¥]®e¤Oªº¤í¯Ê |
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ÁÂÁ Cliff¤j ªº»¡©ú¸Ñ¦M »¡¯uªº Cliff¤j ªº¤j¤å³£¤Ó¦³²`«× Ãø«× ¤p§Ì¤]³£¬OÃjÀ´§zÔ¬§]´Ç ¸g±`±i«a§õÀ¹ ·d¿ù«ÂI «¢! èè¤p§Ì¥»·Q§i¶D ¯E§b¤j ±z¬O¬Û«HFDAªº±M®a ÁÙ¬OJ¨¥¶Ã»yªº¤p§Ì? ¹ï¤£°_ ¯uªº«Ü©êºp ÁÂÁ¤j®a! |
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·|û¡GCliff10135274 µoªí®É¶¡:2015/6/16 ¤W¤È 09:07:59²Ä 1334 ½g¦^À³
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·|û¡G²q·Q10136148 µoªí®É¶¡:2015/6/15 ¤U¤È 08:00:34²Ä 1328 ½g¦^À³
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·|û¡GCliff10135274 µoªí®É¶¡:2015/6/14 ¤U¤È 08:45:42²Ä 1307 ½g¦^À³
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µ½¤H¤j¡G 104/6/13 ¤U¤È 08:00:43ªº¶K¤å¤£´N¤w¸g§âì¤å§e²{¤F¡H±z«ç»ò²{¦b¤~¬ðµM¹y®©¡H ¡uProgressive Disease (PD): At least a 20% increase in the sum of diameters of target lesions, taking as reference the smallest sum on study (this includes the baseline sum if that is the smallest on study). In addition to the relative increase of 20%, the sum must also demonstrate an absolute increase of at least 5 mm. (Note: the appearance of one or more new lesions is also considered progression).¡v |
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